Newest studies

Effects of obesity on plasma biomarker and amyloid PET trajectories in Alzheimer's disease

57/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Higher body mass index at baseline was correlated with lower levels of plasma phosphorylated tau (p-tau)217, p-tau217 ratio, neurofilament light chain (NfL), glial fibrillary acidic protein, and CLs. +3 more findings

• Biomarkers
• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage and subjective cognitive function among older Black women

39/100 ✓ Peer-reviewed Risk factors Psychology and aging

Key finding: Black Americans a have higher risk of cognitive impairment relative to other racial/ethnic groups, and Black women have the highest prevalence of Alzheimer's disease and related dementias; however, the mechanisms underlying cognitive impairment are poorly understood. +3 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Looking into Abnormal Co-Expressions of Tau and TDP-43 in the Realm of Mixed Dementia Types: A Double-Punch Scenario

40/100 ✓ Peer-reviewed Brain tissue and pathology Brain Sciences

Key finding: Additionally, we provide representative examples of their clinical presentations, neuroimaging, and neuropathological findings associated with FTLD-TDP and FTLD-tau, emphasizing the need for a comprehensive understanding of these intertwined pathologies. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cardiovascular-kidney-metabolic syndrome, systemic inflammation, and incident dementia: evidence from 400,740 UK Biobank participants

41/100 ✓ Peer-reviewed Long-term cohort studies Diabetology & Metabolic Syndrome

Key finding: Compared with stage 0 CKM syndrome, stages 3 and 4 were significantly associated with an increased risk of dementia (hazard ratio [HR], 1.35; 95% confidence interval [CI], 1.14-1.59; HR, 1.80; 95% CI 1.57-2.07). +4 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Summary of the best evidence for non-pharmaceutical interventions for mild cognitive impairment in Parkinson’s disease

49/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Neurology

Key finding: Thirteen studies were included (five guidelines, two clinical decisions, two systematic reviews, one meta-analysis, and three RCTs). +2 more findings

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

Sex differences in risk factors associated with Alzheimer’s dementia patients with irritability and anger

45/100 ✓ Peer-reviewed Risk factors Archives of Gerontology and Geriatrics Plus

Key finding: This study reveals key sex differences in ADIA patients. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

Decline in incidence and prevalence of dementia: An analysis of outpatient claims data

37/100 ✓ Peer-reviewed How common it is Deutsches Ärzteblatt international

Key finding: The incidence of dementia declined by 26% percent (95% confidence interval: -26.2; -25.3), from 2020 per 100 000 insured individuals in 2015 to 1500 per 100 000 in 2022. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Reliability of remote self-administered digital cognitive assessments: preliminary validation study

44/100 ✓ Peer-reviewed Getting a diagnosis Frontiers in Digital Health

Key finding: We found moderate or good agreement between self- and RC-administered performance, with intraclass correlation ranging from 0.59 to 0.83. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Assessing family history and approaches for identifying patients with dementia with diagnostically significant genetic findings

43/100 ✓ Peer-reviewed Treatments Genetics in Medicine

Key finding: A positive family history was reported in 42% of patients in the Alzheimer disease cohort, 48% of patients in the frontotemporal dementia cohort, and 34% in those with other dementia types. +4 more findings

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Impact of the DEDICATED approach to optimizing palliative care for people with dementia: a multi-method study

49/100 ✓ Peer-reviewed End-of-life care BMC Health Services Research

Key finding: The DEDICATED approach was implemented across 28 wards in three healthcare organizations. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Lung ultrasound (LUS) as a predictor of delirium in elderly patients with COVID-19 during hospitalization: A geriatric vulnerability-stress model

44/100 ✓ Peer-reviewed Clinical safety Archives of Gerontology and Geriatrics Plus

Key finding: LUS and cognitive impairment are strong predictors of delirium in elderly COVID-19 patients. +2 more findings

• Care Services
• Diagnosis

Full summary, score breakdown and related studies → Original source

Cultural adaptation and psychometric validation of the Turkish MIND diet adherence scale for young adults

39/100 ✓ Peer-reviewed Prevention trials BMC Public Health

Key finding: The study determined an adequate sample size (KMO = 0.67), with sufficient item correlations for factor analysis (χ2 = 449.74; p < 0.001). +4 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease

42/100 ✓ Peer-reviewed Disease mechanisms Journal of Ethnopharmacology

Key finding: It has been demonstrated to have neuroprotective effects in cellular models of neurodegenerative diseases; however, its precise mechanism of action in alleviating tau pathology in Alzheimer's disease (AD), as well as its potential to improve cognitive deficits in animal models, has not yet been elucidated. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes

39/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Disease

Key finding: In this study, we saw many changes primarily associated with inflammatory response, with some changes being transient (Tnf, Lsr; VEGF) and others remaining chronically altered (Osmr, Ccl3; CTSD).

• Brain Biology

Full summary, score breakdown and related studies → Original source

Survival rates in frontotemporal dementia and Alzheimer’s disease

40/100 ✓ Peer-reviewed Lewy body dementia Neurodegenerative Disease Management

Key finding: Median survival from symptom onset was longest in SD (11.9 years) and shortest in LPA (7 years). +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications

45/100 ✓ Peer-reviewed Lewy body dementia Cell

Key finding: To elucidate key intercellular pathways, we employ a VaD mouse model with focal ischemia replicating many elements of the complex pathophysiology of human VaD combined with transcriptomic and functional analyses. +4 more findings

• Other Dementias
• Treatments

Full summary, score breakdown and related studies → Original source

Iron species in cerebrospinal fluid and dementia risk in subjects with mild cognitive impairment: A cohort study

50/100 ✓ Peer-reviewed How common it is NeuroToxicology

Key finding: In this cohort, 28 participants developed Alzheimer's dementia, 5 frontotemporal dementia, 2 Lewy body dementia, and 2 vascular dementia during the follow-up. +4 more findings

• Risk Factors
• Early Stage
• Biomarkers

Full summary, score breakdown and related studies → Original source

Systemic disadvantages facing UK ethnic elders within dementia healthcare

35/100 ✓ Peer-reviewed Disparities BJPsych Advances

Key finding: Reduced access to dementia healthcare services by elders from ethnic minority backgrounds is often a manifestation of underlying systemic disadvantages within dementia assessment and treatment services. +4 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Factors Influencing Psychological Distress in Caregivers of People with Dementia

35/100 ✓ Peer-reviewed Caregiving Healthcare

Key finding: The research findings revealed that 26.2% of the sample experienced psychological distress. +3 more findings

• Caregiving

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Caregiver-involved reminiscence for persons with dementia: a scoping review protocol

50/100 ✓ Peer-reviewed Caregiving Systematic Reviews

Key finding: This protocol will outline the scoping review of current literature on caregiver-involved reminiscence for persons with dementia. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

A novel neuroimaging based early detection framework for alzheimer disease using deep learning

47/100 ✓ Peer-reviewed Brain scans and imaging Scientific Reports

Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that significantly impacts cognitive function, posing a major global health challenge.

• Brain Scans
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Classifying and diagnosing Alzheimer’s disease with deep learning using 6735 brain MRI images

46/100 ✓ Peer-reviewed Brain scans and imaging Scientific Reports

Key finding: Notably, InceptionResnetV2 and VGG19 demonstrated faster learning, reaching convergence sooner and requiring fewer training iterations than other models. +1 more finding

• Brain Scans
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders

49/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: NfL holds potential as a blood-based biomarker for symptomatic genetic FTD carriers, with moderate accuracy to distinguish PPD from mild forms including C9orf72 . +2 more findings

• Biomarkers
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Reliability and validity analysis of the Chinese version of the Quick Dementia Rating System (QDRS)

45/100 ✓ Peer-reviewed Getting a diagnosis BMC Geriatrics

Key finding: There were strong correlations between the C-QDRS and standardized neuropsychological tests, indicating that the C-QDRS exhibited concurrent validity (all P < 0.001). +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Neighborhood deprivation and mortality among people with Alzheimer's disease and related dementia

41/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Multivariate logistic regression was applied to examine the association between ADI and all-cause mortality among beneficiaries with AD/ADRD.ResultsAfter adjusting for patients characteristics, compared to the lowest ADI quartile (Q1), higher ADI quartiles were associated with higher odds of all-cause mortality in individuals with AD/ADRD (Q2 = OR 1.08 [95% CI: 1.06, 1.10], Q3 = OR 1.09 [95% CI: 1.07, 1.11], and Q4 OR 1.05 [95% CI: 1.03, 1.07]).ConclusionsNeighborhood deprivation is an independent risk factor for mortality in persons with AD/ADRD.

Full summary, score breakdown and related studies → Original source