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Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data
Kathryn A Wyman‐Chick, Tanis J. Ferman, Melissa J. Armstrong, Ella A. B. Chrenka, Shannon Chiu, Bhavana Patel, Matthew J. Barrett, Ece Bayram. Alzheimer s & Dementia, 2025-05-01
Topic: Risk, prevention and care in population studies
Males were more likely than females to present with two or more core DLB clinical features 2 years prior to obtaining a diagnosis of dementia. Rapid eye movement sleep behavior disorder, cognitive fluctuations, bradykinesia, and rigidity were more common in males than females. Neuropsychological test performance was similar between groups. In prodromal DLB, males exhibit a greater number of core features than females. Core DLB features may fall short in identifying females at risk. Additional work is needed to better understand the clinical profile of prodromal DLB in females. HIGHLIGHTS: There are sex differences in the presentation and course of neurodegenerative disease. Findings from the National Alzheimer's Coordinating Center Uniform Data Set suggest there are sex differences in prodromal DLB symptoms. Females were less likely to demonstrate core clinical features of DLB prior to dementia diagnosis. This information can help inform clinical diagnostic criteria for prodromal DLB.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wyman‐Chick, K. A., Ferman, T. J., Armstrong, M. J., Chrenka, E. A. B., Chiu, S., Patel, B., et al. (2025). Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70275
Vancouver
Wyman‐Chick KA, Ferman TJ, Armstrong MJ, Chrenka EAB, Chiu S, Patel B, et al. Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70275. PMID: 40390234.
BibTeX
@article{wymanchick2025-40390234,
author = {Wyman‐Chick, Kathryn A and Ferman, Tanis J. and Armstrong, Melissa J. and Chrenka, Ella A. B. and Chiu, Shannon and Patel, Bhavana and Barrett, Matthew J. and Bayram, Ece},
title = {{Sex differences in prodromal dementia with Lewy bodies using the National Alzheimer's Coordinating Center data}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70275},
pmid = {40390234},
url = {https://doi.org/10.1002/alz.70275}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Males were more likely than females to present with two or more core DLB clinical features 2 years prior to obtaining a diagnosis of dementia.
- Rapid eye movement sleep behavior disorder, cognitive fluctuations, bradykinesia, and rigidity were more common in males than females.
- Neuropsychological test performance was similar between groups.
- In prodromal DLB, males exhibit a greater number of core features than females.
- Core DLB features may fall short in identifying females at risk.
Why it matters
This longitudinal study found that in prodromal dementia with Lewy bodies, males exhibit a greater number of core features than females, and that core features may fall short in identifying females at risk. It is about sex differences in presentation, not about treating, curing or preventing dementia.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 49/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ece Bayram: h-index 23 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Florida: institution h-index 1,303 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40390234) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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