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Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study
Zarui A. Melikyan, Colette Aguirre, Zeinah Al‐Darsani, Katherine A. Colcord, Annlia Paganini‐Hill, Sarah Tomaszewski Farias, Luohua Jiang, Claudia H. Kawas et al.. International Psychogeriatrics, 2025-05-08
Topic: Risk, prevention and care in population studies
In 893 participants with average age 93 years (range 90-102), 43 % had SMC. Cross-sectionally, SMC were associated with lower scores on memory, language, executive function. After 3.5 years of follow-up (range 0.4-16), 325 of 789 participants developed dementia. SMC, compared with no SMC, was associated with twice the risk of incident dementia (HR=2.16, 95 %CI, 1.72-2.72; p < 0.01). SMC predicted incident dementia as well as MMSE (p = 0.12), but not as well as cognitive diagnosis (p < 0.01). Single SMC question might be useful to identify oldest old with cognitive impairment or at risk of dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Melikyan, Z. A., Aguirre, C., Al‐Darsani, Z., Colcord, K. A., Paganini‐Hill, A., Farias, S. T., et al. (2025). Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study. International Psychogeriatrics. https://doi.org/10.1016/j.inpsyc.2025.100083
Vancouver
Melikyan ZA, Aguirre C, Al‐Darsani Z, Colcord KA, Paganini‐Hill A, Farias ST, et al. Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study. International Psychogeriatrics. 2025. doi:10.1016/j.inpsyc.2025.100083. PMID: 40340138.
BibTeX
@article{melikyan2025-40340138,
author = {Melikyan, Zarui A. and Aguirre, Colette and Al‐Darsani, Zeinah and Colcord, Katherine A. and Paganini‐Hill, Annlia and Farias, Sarah Tomaszewski and Jiang, Luohua and Kawas, Claudia H. and others},
title = {{Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study}},
journal = {International Psychogeriatrics},
year = {2025},
doi = {10.1016/j.inpsyc.2025.100083},
pmid = {40340138},
url = {https://doi.org/10.1016/j.inpsyc.2025.100083}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In 893 participants with average age 93 years (range 90-102), 43 % had SMC.
- Cross-sectionally, SMC were associated with lower scores on memory, language, executive function.
- After 3.5 years of follow-up (range 0.4-16), 325 of 789 participants developed dementia.
- SMC, compared with no SMC, was associated with twice the risk of incident dementia (HR=2.16, 95 %CI, 1.72-2.72; p < 0.01).
- SMC predicted incident dementia as well as MMSE (p = 0.12), but not as well as cognitive diagnosis (p < 0.01).
Why it matters
In people aged 90 and older, having subjective memory complaints was linked to about twice the risk of developing dementia over roughly 3.5 years. A single question about memory complaints might help identify the oldest old who have cognitive impairment or are at risk of dementia.
Study details
- Study designcross-sectional
- Participants893
- Effect sizeHR=2.16
- Evidence strengthModerate
How this study scored 52/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International Psychogeriatrics) |
| Journal's citation record | 2 / 4 | International Psychogeriatrics: journal h-index 161 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 893 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author María M. Corrada: h-index 55 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Davis: institution h-index 1,257 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40340138) |
| Free to read | 2 / 2 | Free to read |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.inpsyc.2025.100083
- PubMed: 40340138
- Original source →
- Free full text: International Psychogeriatrics →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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