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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,851–16,875 of 27,380 studies, newest first · page 675 of 1096.

July 2015 10

  1. 2015-07-01

    Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance

    ✓ Peer-reviewed Disease mechanisms Journal of clinical biochemistry and nutrition

    Key finding: Aging and chronic diseases are strongly associated with markers for oxidative stress, especially advanced glycation end-products, and resistance to peripheral insulin-mediated glucose uptake. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2015-07-01

    The Worldwide Alzheimer's Disease Neuroimaging Initiative: An update

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: ADNI is a naturalistic (nontreatment) multisite longitudinal study. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2015-07-01

    Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD)

    ✓ Peer-reviewed TREM2 and immune genetics Journal of nature and science

    Key finding: In the last 18 months multiple laboratories have reported two particularly important observations: (i) that because the microbes of the human microbiome naturally secrete large amounts of amyloid, lipopolysaccharides (LPS) and other related pro-inflammatory pathogenic signals, these may contribute to both the systemic and CNS amyloid burden in aging humans; and (ii) that the clearance of Aβ peptides appears to be intrinsically impaired by deficits in the microglial plasma-membrane enriched triggering receptor expressed in microglial/myeloid-2 cells (TREM2). +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2015-07-01

    Progression of mild cognitive impairment to dementia due to AD in clinical settings

    ✓ Peer-reviewed Mild cognitive impairment Neurology

    Key finding: Under circumstances emulating routine clinical practice, the positive predictive value of an MCI diagnosis is in line with previous clinical studies and the external validity of the concept is strengthened. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2015-07-01

    Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics

    ✓ Peer-reviewed Mild cognitive impairment Archives of toxicology

    Key finding: Alzheimer disease (AD) is a neurodegenerative disease with many known pathological features, yet there is still much debate into the exact cause and mechanisms for progression of this degenerative disorder. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2015-07-01

    Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy

    Key finding: However, in AD cerebral grey matter is affected very early, with pathological studies suggesting that grey matter changes predate those in white matter. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2015-07-01

    A systematic review of the public's knowledge and understanding of Alzheimer's disease and dementia

    ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders

    Key finding: The review revealed a lack of consistency across studies regarding how knowledge was operationalized, approaches to sampling, response rates, and data collection instruments used including validated scales.

    Full summary, score breakdown and related studies → Original source

  8. 2015-07-01

    Adaptive, dose-finding phase 2 trial evaluating the safety and efficacy of ABT-089 in mild to moderate Alzheimer disease

    ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders

    Key finding: No dose-response relationship was observed and no dose demonstrated statistically significant improvement over placebo on ADAS-Cog or any secondary endpoint.

    Full summary, score breakdown and related studies → Original source

  9. 2015-07-01

    Clinical Features of Alzheimer Disease With and Without Lewy Bodies

    ✓ Peer-reviewed Genetics JAMA neurology

    Key finding: The mean (SD) age at death was statistically significantly younger for participants who had AD with Lewy bodies (77.9 [9.5] years) than for participants who had AD without Lewy bodies (80.2 [11.1] years) (P = .01). +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2015-07-01

    Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: We determined that several iterations of the discriminant analysis improved the classification of subjects into the AβL and AβH groups. +1 more finding

    Full summary, score breakdown and related studies → Original source

June 2015 15

  1. 2015-06-30

    [(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-β pathology

    ✓ Peer-reviewed End-of-life care Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: [(18)F]flutemetamol amyloid PET detects primarily advanced stages of Aβ pathology in preclinical and symptomatic AD cases.

    Full summary, score breakdown and related studies → Original source

  2. 2015-06-30

    Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

    ✓ Peer-reviewed Drug development The Journal of biological chemistry

    Key finding: Size fractionation of aggregates showed that antibodies preferentially promote uptake of larger oligomers (n ≥ ∼ 20-mer) versus smaller oligomers (n ∼ 10-mer) or monomer.

    Full summary, score breakdown and related studies → Original source

  3. 2015-06-30

    Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia

    ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

    Key finding: However, several neurodegenerative disorders may overlap with Alzheimer's disease both in regards to clinical symptoms and neuropathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2015-06-30

    Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study

    ✓ Peer-reviewed Genetics The Lancet. Neurology

    Key finding: It was one of the genes most strongly associated with risk of Alzheimer's disease in a Belgian cohort. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2015-06-29

    Association between comorbidities and dementia in diabetes mellitus patients: population-based retrospective cohort study

    ✓ Peer-reviewed Digital health tools Journal of diabetes and its complications

    Key finding: Diabetic patients have an elevated risk of dementia, and comorbidity increases this risk.

    Full summary, score breakdown and related studies → Original source

  6. 2015-06-29

    The interface between delirium and dementia in elderly adults

    ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

    Key finding: Previous studies have shown that dementia is the leading risk factor for delirium and that delirium is an independent risk factor for subsequent development of dementia.

    Full summary, score breakdown and related studies → Original source

  7. 2015-06-26

    Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions

    ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology

    Key finding: Although cortical superficial siderosis has many possible causes, it is emerging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral small vessel disorder leading to intracerebral haemorrhage and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2015-06-25

    Alzheimer's disease progression by geographical region in a clinical trial setting

    ✓ Peer-reviewed Clinical trials Alzheimer's research & therapy

    Key finding: At baseline, disease severity as measured by ADAS-cog11, ADCS-ADL, and CDR-SB was numerically worse for Eastern Europe/Russia compared with other regions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2015-06-25

    HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

    ✓ Peer-reviewed Drug development Cell metabolism

    Key finding: Here, statins, inhibitors of HMG-CoA reductase and cholesterol lowering drugs, were found to stimulate expression of neurotrophins in brain cells independent of the mevalonate pathway. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2015-06-24

    Usability and Validity of a Battery of Computerised Cognitive Screening Tests for Detecting Cognitive Impairment

    ✓ Peer-reviewed Cognitive tests and assessment Gerontology

    Key finding: The participants had little difficulty self-administering the CCS, which is an oft-cited barrier to computerised testing in this population. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2015-06-20

    Checks and balances on cholinergic signaling in brain and body function

    ✓ Peer-reviewed Risk factors Trends in neurosciences

    Key finding: Recent discoveries indicate that pre- and post-transcriptional ACh signaling controllers coordinate the identity, functioning, dynamics, and brain-to-body communication of cholinergic cells.

    Full summary, score breakdown and related studies → Original source

  12. 2015-06-20

    Recommendations for the use of PET imaging biomarkers in the diagnosis of neurodegenerative conditions associated with dementia: SEMNIM and SEN consensus

    ✓ Peer-reviewed Disease mechanisms Revista espanola de medicina nuclear e imagen molecular

    Key finding: The new diagnostic criteria for Alzheimer's disease (AD) acknowledges the interest given to biomarkers to improve the specificity in subjects with dementia and to facilitate an early diagnosis of the pathophysiological process of AD in the prodromal or pre-dementia stage. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2015-06-19

    Oxidized cholesterol as the driving force behind the development of Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

    Key finding: Considerable evidence indicates that many events contribute to AD progression, including oxidative stress, inflammation, and altered cholesterol metabolism. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2015-06-18

    Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans

    ✓ Peer-reviewed Disease mechanisms Annals of neurology

    Key finding: Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2015-06-18

    Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

    ✓ Peer-reviewed Disease mechanisms Cell death & disease

    Key finding: Our data suggest that Aβ induces the activation of p38 MAPK and subsequent synaptic loss through Ca(2+) flux- and G protein-independent mechanisms.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →