Newest studies

Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease

33/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: BackgroundEpigenetic mechanisms, particularly histone modifications at gene promoters, are crucial for controlling gene transcription. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Genetic contributions to Alzheimer’s disease and frontotemporal dementia in admixed Latin American populations

48/100 ✓ Peer-reviewed Lewy body dementia npj Dementia

Key finding: The study revealed a predominant mix of American, African, and European ancestries, with an additional East Asian component in Brazil.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

From Anxiety, Depression to Major Neurocognitive Disorders: Exploring Their Association With the Risk Factors for Dementia

54/100 ✓ Peer-reviewed Risk factors Cureus

Key finding: Our manuscript is a narrative review of peer-reviewed systematic reviews and meta-analyses examining the association between common psychiatric disorders, namely depression, bipolar disorder, anxiety, post traumatic stress disorder (PTSD), schizophrenia, and the onset of neurocognitive decline. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Glymphatic system dysfunction as a predictor of cognitive decline and incident dementia

48/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer s Disease

Key finding: This longitudinal evidence supports a link between the ALPS-I and cognitive degeneration. +2 more findings

• Diagnosis
• Risk Factors

Full summary, score breakdown and related studies → Original source

Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

50/100 ✓ Peer-reviewed Biomarkers JAMA Psychiatry

Key finding: This cohort study examines the association of serum hyperphosphorylated tau and neurofilament light chain concentrations with psychosis in Alzheimer disease.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Alcohol use and risk of dementia in diverse populations: evidence from cohort, case-control and Mendelian randomisation approaches

68/100 ✓ Peer-reviewed Prevention and risk BMJ Evidence-Based Medicine

Key finding: These findings provide evidence for a relationship between all types of alcohol use and increased dementia risk. +4 more findings

• Risk Factors
• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease

60/100 ✓ Peer-reviewed Clinical trials The Journal of Prevention of Alzheimer's Disease

Key finding: It was not possible to demonstrate significant differences on the co-primary clinical endpoints (ADAS-cog 11 and ADCS-ADL 23 ) at 52 weeks due to symptomatic activity in the control arm. +4 more findings

• Clinical Trials
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Plasma p-Tau217 improves diagnostic accuracy and clinician confidence in cognitive disorder classification

55/100 ✓ Peer-reviewed Biomarkers Innovation (Cambridge (Mass.))

Key finding: Incorporating plasma p-tau217 into the routine tier 2 diagnostic workup significantly influenced clinical decision-making, leading to diagnostic revisions in 30.2% of cases and improving overall diagnostic confidence from 65.1% to 79.4%. +4 more findings

• Biomarkers
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Limited Diagnostic Performance of Cerebrospinal Fluid Glial Fibrillary Acidic Protein in Dementia

58/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia and Geriatric Cognitive Disorders

Key finding: A total of 1,345 individuals were included. +4 more findings

• Diagnosis
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Multidomain intervention for dementia prevention: a scoping review

40/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in Neurology

Key finding: Eighteen studies identified four core components of multidomain interventions: physical exercise, cognitive training, nutrition, and cardiovascular risk management. +4 more findings

• Prevention
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

The Application of Artificial Intelligence to Older Adults With Disabilities: A Scoping Review

43/100 ✓ Peer-reviewed Digital health tools Journal of Applied Gerontology

Key finding: ObjectiveTo review the application of artificial intelligence (AI) in the care of older adults with disabilities, identifying intervention type, target populations, and effects. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Association between plant-based diets and incident dementia: results from prospective cohort studies and a meta-analysis

66/100 ✓ Peer-reviewed Prevention and risk The journal of prevention of Alzheimer's disease

Key finding: In the cohort analyses, 891 incident dementia cases were identified over 166,762 person-years. +3 more findings

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Population attributable fractions of a wide range of peripheral diseases for the burden of dementia

56/100 ✓ Peer-reviewed How common it is Nature human behaviour

Key finding: Growing evidence suggests that peripheral diseases serve as risk factors for dementia, but the population-level burden of dementia associated with various peripheral diseases has remained unknown. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cadmium Exposure and Incidence of All-Cause Dementia and Alzheimer’s Disease in US Adults

16/100 ⚠ Preprint — not yet peer-reviewed Costs and economics medRxiv

Key finding: No association between cadmium exposure and dementia incidence was observed. +1 more finding

• Risk Factors

Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Pharmacotherapy for Alzheimer’s Disease and Dementias in Long-Term Care: A Real-World EHR Study

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: More than one-quarter of residents with ADRD remain untreated with guideline-recommended pharmacotherapy, and treatment varied significantly by non-clinical predictors. +4 more findings

• Care Services
• Treatments

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Early Alzheimer's diagnosis: U.S. primary care physicians and use of blood biomarkers

43/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Barriers include the complexity and inefficiency of current diagnostic workflows, lack of effective treatments, and stigma. +4 more findings

• Care Services
• Diagnosis
• Biomarkers

Full summary, score breakdown and related studies → Original source

Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers Predicting Neuropsychiatric Symptom Progression in Mild Cognitive Impairment and Alzheimer's Disease

54/100 ✓ Peer-reviewed Mild cognitive impairment The FASEB Journal

Key finding: Incorporating selected CSF proteins significantly improved NPS prediction compared to the reference model, with AUCs increasing from 0.64 to 0.76 at baseline, 0.63 to 0.80 at 1 year, and 0.63 to 0.81 at 2 years. +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Potentially inappropriate medications related to two-year progression of mild cognitive impairment and dementia

49/100 ✓ Peer-reviewed Mild cognitive impairment European Journal of Clinical Pharmacology

Key finding: The prevalence of PIMcogs increased from 16% at baseline to 23% at follow-up. +4 more findings

• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future

48/100 ✓ Peer-reviewed Digital health tools Neuropsychopharmacology

Key finding: Nutraceuticals, such as Ginkgo biloba and butylphthalide, have some supportive data and may be similarly helpful. +4 more findings

• Treatments
• Other Dementias
• Digital Tools

Full summary, score breakdown and related studies → Original source

Diabetes and its complications: molecular mechanisms, prevention and treatment

51/100 ✓ Peer-reviewed Prevention and risk Signal Transduction and Targeted Therapy

Key finding: Advances in spatial multiomics and single-cell transcriptomic techniques, along with insights into aberrant signaling via myokines, cytokines, hormones, the gut microbiota, and exosomes, have revealed the molecular heterogeneity and dynamic inter-organ crosstalk underlying diabetes. +1 more finding

• Prevention
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Aldehyde-Mediated Neurotoxicity and Lutein Intervention: A Novel Therapeutic Strategy for Alzheimer's Disease

29/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: These aldehydes are direct mediators of neuronal injury and can result in covalent conjugates with proteins, mitochondrial dysfunction, and neuroinflammation and protein aggregation.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Aldehyde-Mediated Neurotoxicity and Lutein Intervention: A Novel Therapeutic Strategy for Alzheimer's Disease

41/100 ✓ Peer-reviewed Treatments Zenodo (CERN European Organization for Nuclear Research)

Key finding: These aldehydes are direct mediators of neuronal injury and can result in covalent conjugates with proteins, mitochondrial dysfunction, and neuroinflammation and protein aggregation.

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Broadband Availability and Alzheimer’s Disease and Related Dementias Prevalence in Central Appalachia

30/100 ✓ Peer-reviewed Risk factors Journal of Social Service Research

Key finding: Appalachian counties had lower ADRD prevalence than non-Appalachian counties in rural compared to urban counties (βAppXRural = −0.028; 95% Confidence Interval (CI): −0.052, −0.005). +1 more finding

Full summary, score breakdown and related studies → Original source

Associations of self- and informant-reported functional impairment with cognitive performance and incident dementia

57/100 ✓ Peer-reviewed Getting a diagnosis The Journal of Prevention of Alzheimer s Disease

Key finding: Self- and informant-reported ADL and IADL impairments were examined at overall and item levels. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

The impact of congenital heart disease on the timing of Alzheimer's disease in Down syndrome

48/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Presence of CHD may influence AD progression in DS.

• Down Syndrome

Full summary, score breakdown and related studies → Original source