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Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments
Kamila P, Kar K, Chowdhury S, Chakraborty P, Dutta R, S S, Singh S A, Prajapati BG.. IBRO neuroscience reports, 2025-05-22
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is increasingly recognized as a disorder not solely of amyloid and tau accumulation but also of chronic immune dysregulation. Emerging evidence highlights the critical role of neuroinflammation, characterized by sustained activation of microglia and astrocytes, cytokine release, and inflammasome activation in accelerating AD progression. Genome-wide studies have further identified key inflammatory genes and immune pathways associated with increased disease risk.
Key findings
- Emerging evidence highlights the critical role of neuroinflammation, characterized by sustained activation of microglia and astrocytes, cytokine release, and inflammasome activation in accelerating AD progression.
- Genome-wide studies have further identified key inflammatory genes and immune pathways associated with increased disease risk.
- This review critically evaluates the mechanistic underpinnings of neuroinflammation in AD, focusing on glial cell behavior, immune signaling, and their contribution to neuronal dysfunction.
- Importantly, the review highlights recent advances in anti-inflammatory therapeutic approaches, including modulators of IL-1β, TNF-α, TREM2, and CB2 pathways.
Why it matters
This review argues that neuroinflammation, including sustained microglia and astrocyte activation and inflammasome activation, contributes to Alzheimer's disease progression, and that inflammatory genes and immune pathways are linked to disease risk. It discusses the rationale for anti-inflammatory treatments but does not report a tested treatment or cure.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (IBRO neuroscience reports) |
| Journal's citation record | 0 / 4 | IBRO Neuroscience Reports: journal h-index 29 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 86 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 28.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 5 / 6 | Cited 25.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 86 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Bhupendra Gopalbhai Prajapati: h-index 41 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Chitkara University: institution h-index 205 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40510290) |
| Free to read | 2 / 2 | Free to read |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.ibneur.2025.05.005
- PubMed: 40510290
- Original source →
- Free full text: IBRO Neuroscience Reports →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Kamila, P., Kar, K., Chowdhury, S., Chakraborty, P., Dutta, R., Singh S, A., et al. (2025). Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments. IBRO neuroscience reports. https://doi.org/10.1016/j.ibneur.2025.05.005
Vancouver
Kamila P, Kar K, Chowdhury S, Chakraborty P, Dutta R, Singh S A, et al. Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments. IBRO neuroscience reports. 2025. doi:10.1016/j.ibneur.2025.05.005. PMID: 40510290.
BibTeX
@article{kamila2025-40510290,
author = {Kamila, P. and Kar, K. and Chowdhury, S. and Chakraborty, P. and Dutta, R. and Singh S, A. and Prajapati, B. G.},
title = {{Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments}},
journal = {IBRO neuroscience reports},
year = {2025},
doi = {10.1016/j.ibneur.2025.05.005},
pmid = {40510290},
url = {https://doi.org/10.1016/j.ibneur.2025.05.005}
}
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