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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. How common it is

Topic: Risk, prevention and care in population studies

Among the 1 268 599 participants (mean age, 73.9 [SD, 6.1] years; n = 25 335 [2%] female), dementia incidence rates per 1000 person-years were lowest in the Mid-Atlantic (11.2; 95% CI, 11.1-11.4) and highest in the Southeast (14.0; 95% CI, 13.8-14.2). Compared with the Mid-Atlantic, the regions with the greatest demographically adjusted incidence included the Southeast (rate ratio [RR], 1.25; 95% CI, 1.22-1.28), Northwest (RR, 1.23; 95% CI, 1.20-1.27), Rocky Mountains (RR, 1.23; 95% CI, 1.20-1.26), South (RR, 1.18; 95% CI, 1.15-1.20), Midwest (RR, 1.12; 95% CI, 1.09-1.14), and South Atlantic (RR, 1.12; 95% CI, 1.10-1.14); the remaining regions had similar (<10% difference) incidence. Additional adjustments for rurality and cardiovascular comorbidities and accounting for the competing risk of death produced similar results. Conclusions and Relevance: Among older adults in the VHA, dementia incidence varied significantly across US regions, independent of key covariates. These findings highlight the need for targeted health care planning, public health interventions, and policy development.

Key findings

Among the 1 268 599 participants (mean age, 73.9 [SD, 6.1] years; n = 25 335 [2%] female), dementia incidence rates per 1000 person-years were lowest in the Mid-Atlantic (11.2; 95% CI, 11.1-11.4) and highest in the Southeast (14.0; 95% CI, 13.8-14.2).
Compared with the Mid-Atlantic, the regions with the greatest demographically adjusted incidence included the Southeast (rate ratio [RR], 1.25; 95% CI, 1.22-1.28), Northwest (RR, 1.23; 95% CI, 1.20-1.27), Rocky Mountains (RR, 1.23; 95% CI, 1.20-1.26), South (RR, 1.18; 95% CI, 1.15-1.20), Midwest (RR, 1.12; 95% CI, 1.09-1.14), and South Atlantic (RR, 1.12; 95% CI, 1.10-1.14); the remaining regions had similar (<10% difference) incidence.
Additional adjustments for rurality and cardiovascular comorbidities and accounting for the competing risk of death produced similar results.
Conclusions and Relevance: Among older adults in the VHA, dementia incidence varied significantly across US regions, independent of key covariates.
These findings highlight the need for targeted health care planning, public health interventions, and policy development.

Why it matters

Among U.S. veterans, dementia incidence varied significantly by region, with the highest rates in the Southeast and lowest in the Mid-Atlantic, even after adjusting for demographic and health factors. This regional variation highlights the need for targeted healthcare planning and public health interventions.

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Study details

Study designcohort study
Participants25
Evidence strengthModerate

How this study scored 54/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA Neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	25 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Kristine S. Yaffe: h-index 155 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, San Francisco: institution h-index 1,915 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40489088)
Free to read	2 / 2	Free to read
Total	54 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Dintica, C. S., Bahorik, A. L., Xia, F., Boscardin, W. J., & Yaffe, K. S. (2025). Regional Differences in Dementia Incidence Among US Veterans. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2025.1536

Vancouver

Dintica CS, Bahorik AL, Xia F, Boscardin WJ, Yaffe KS. Regional Differences in Dementia Incidence Among US Veterans. JAMA Neurology. 2025. doi:10.1001/jamaneurol.2025.1536. PMID: 40489088.

BibTeX

@article{dintica2025-40489088,
  author  = {Dintica, Christina S. and Bahorik, Amber L. and Xia, Feng and Boscardin, W. John and Yaffe, Kristine S.},
  title   = {{Regional Differences in Dementia Incidence Among US Veterans}},
  journal = {JAMA Neurology},
  year    = {2025},
  doi     = {10.1001/jamaneurol.2025.1536},
  pmid    = {40489088},
  url     = {https://doi.org/10.1001/jamaneurol.2025.1536}
}

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