White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
Christopher Peter, Aditi Sathe, Niranjana Shashikumar, Kimberly R. Pechman, Abigail W. Workmeister, Trevor Bryan Jackson, Yuankai Huo, Shubhabrata Mukherjee et al.. JAMA Neurology, 2025-06-09
Topic: Amyloid, tau and blood-test diagnosis
Results Of 4467 participants who underwent 9208 longitudinal cognitive sessions, 2698 (60.4%) were female, and the mean age (SD) was 74.3 (9.2) years; 3213 were cognitively unimpaired, 972 had mild cognitive impairment, and 282 had AD dementia. These findings highlight the importance of FW correction in dMRI studies and highlight the limbic system, especially the cingulum and fornix, as key regions associated with cognitive decline; the interaction models highlight that integrating FW-corrected metrics with other AD biomarkers may further elucidate the biological mechanisms of neurodegeneration in aging.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Peter, C., Sathe, A., Shashikumar, N., Pechman, K. R., Workmeister, A. W., Jackson, T. B., et al. (2025). White Matter Abnormalities and Cognition in Aging and Alzheimer Disease. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2025.1601
Vancouver
Peter C, Sathe A, Shashikumar N, Pechman KR, Workmeister AW, Jackson TB, et al. White Matter Abnormalities and Cognition in Aging and Alzheimer Disease. JAMA Neurology. 2025. doi:10.1001/jamaneurol.2025.1601. PMID: 40513084.
BibTeX
@article{peter2025-40513084,
author = {Peter, Christopher and Sathe, Aditi and Shashikumar, Niranjana and Pechman, Kimberly R. and Workmeister, Abigail W. and Jackson, Trevor Bryan and Huo, Yuankai and Mukherjee, Shubhabrata and others},
title = {{White Matter Abnormalities and Cognition in Aging and Alzheimer Disease}},
journal = {JAMA Neurology},
year = {2025},
doi = {10.1001/jamaneurol.2025.1601},
pmid = {40513084},
url = {https://doi.org/10.1001/jamaneurol.2025.1601}
}
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Key findings
- Results Of 4467 participants who underwent 9208 longitudinal cognitive sessions, 2698 (60.4%) were female, and the mean age (SD) was 74.3 (9.2) years; 3213 were cognitively unimpaired, 972 had mild cognitive impairment, and 282 had AD dementia.
- These findings highlight the importance of FW correction in dMRI studies and highlight the limbic system, especially the cingulum and fornix, as key regions associated with cognitive decline; the interaction models highlight that integrating FW-corrected metrics with other AD biomarkers may further elucidate the biological mechanisms of neurodegeneration in aging.
Why it matters
The study highlights the importance of free-water correction in diffusion MRI and points to the limbic system, especially the cingulum and fornix, as key regions associated with cognitive decline. It is about imaging markers of neurodegeneration, not about treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designcohort study
- Participants4,467
- Effect size60.4%
- Evidence strengthModerate
How this study scored 70/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA Neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 4,467 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 55 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 18.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 5 / 6 | Cited 34.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 55 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Garrett Miller: h-index 15 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | University of Washington: institution h-index 3,540 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 20 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40513084) |
| Free to read | 2 / 2 | Free to read |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamaneurol.2025.1601
- PubMed: 40513084
- Original source →
- Free full text: JAMA Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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