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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Disparities

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Higher ARTS score was associated (all ps < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample. Results varied across racial and ethnic groups. ARTS has utility as an in vivo marker of cerebral arteriolosclerosis and risk of MCI, dementia, and stroke. HIGHLIGHTS: ARTS score, an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment (MCI), dementia, and stroke in a diverse sample. ARTS score was associated with incident dementia in the non-Latino (NL) White and NL Black subgroups separately. ARTS score was associated with incident MCI in the NL Black subgroup. Common vascular risk factors were associated with ARTS score, consistent with ex vivo studies. ARTS has utility as a marker for the risk of MCI, dementia, and stroke.

What this study adds

Evidence grade: Low

The record lists 707 participants. Higher ARTS score, described as an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment, dementia, and stroke, and with vascular risk factors. Reported effect size: HR = 1.33; HR = 1.52.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Fleischman, D. A., Arfanakis, K., Leurgans, S. E., Evia, A. M., Lamar, M., Kapasi, A., et al. (2025). ARTS is associated with vascular risk factors, MCI, dementia, and stroke. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70430

Vancouver

Fleischman DA, Arfanakis K, Leurgans SE, Evia AM, Lamar M, Kapasi A, et al. ARTS is associated with vascular risk factors, MCI, dementia, and stroke. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70430. PMID: 40588724.

BibTeX

@article{fleischman2025-40588724,
  author  = {Fleischman, Debra A. and Arfanakis, Konstantinos and Leurgans, Sue E. and Evia, Arnold Moya and Lamar, Melissa and Kapasi, Alifiya and Han, S. Duke and Poole, Victoria N. and others},
  title   = {{ARTS is associated with vascular risk factors, MCI, dementia, and stroke}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70430},
  pmid    = {40588724},
  url     = {https://doi.org/10.1002/alz.70430}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record lists 707 participants. Ask whether that is enough for the question, and who they were.
Effect: the record reports “HR = 1.33; HR = 1.52”. A statistically significant result can still be small in daily life.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Higher ARTS score was associated (all ps < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample.
Results varied across racial and ethnic groups.
ARTS has utility as an in vivo marker of cerebral arteriolosclerosis and risk of MCI, dementia, and stroke.
HIGHLIGHTS: ARTS score, an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment (MCI), dementia, and stroke in a diverse sample.
ARTS score was associated with incident dementia in the non-Latino (NL) White and NL Black subgroups separately.

Why it matters

Higher ARTS score, described as an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment, dementia, and stroke, and with vascular risk factors. This points to a possible marker of risk related to blood vessel disease, but it does not show a treatment or cure.

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Study details

Participants707
Effect sizeHR = 1.33; HR = 1.52
Evidence strengthLow

How this study scored 49/100

Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	707 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 7 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	2.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 4.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Lisa Laverne Barnes: h-index 95 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Southern California: institution h-index 1,521 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40588724)
Free to read	2 / 2	Free to read
Total	49 / 100	—

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