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Neighborhood deprivation and mortality among people with Alzheimer's disease and related dementia
Joshua L. Paley, Grant D. Scheiffele, Yujia Li, C. Elizabeth Shaaban, Yonghui Wu, Stephen Douglas Anton, Steven T. DeKosky, Jiang Bian et al.. Journal of Alzheimer s Disease, 2025-07-02
Topic: Amyloid, tau and blood-test diagnosis
BackgroundThere are limited studies quantifying the extent to which neighborhood deprivation affects mortality in individuals living with Alzheimer's disease (AD) and AD-related dementias (AD/ADRD).ObjectiveTo quantify to what extent neighborhood deprivation affects adverse outcomes in individuals living with AD/ADRD.MethodsWe identified individuals with AD/ADRD using a 15% random sample of national Medicare fee-for-service beneficiaries. Area deprivation index (ADI) was spatially linked to the Medicare AD/ADRD cohort using zip codes. Multivariate logistic regression was applied to examine the association between ADI and all-cause mortality among beneficiaries with AD/ADRD.ResultsAfter adjusting for patients characteristics, compared to the lowest ADI quartile (Q1), higher ADI quartiles were associated with higher odds of all-cause mortality in individuals with AD/ADRD (Q2 = OR 1.08 [95% CI: 1.06, 1.10], Q3 = OR 1.09 [95% CI: 1.07, 1.11], and Q4 OR 1.05 [95% CI: 1.03, 1.07]).ConclusionsNeighborhood deprivation is an independent risk factor for mortality in persons with AD/ADRD.
Key findings
- Multivariate logistic regression was applied to examine the association between ADI and all-cause mortality among beneficiaries with AD/ADRD.ResultsAfter adjusting for patients characteristics, compared to the lowest ADI quartile (Q1), higher ADI quartiles were associated with higher odds of all-cause mortality in individuals with AD/ADRD (Q2 = OR 1.08 [95% CI: 1.06, 1.10], Q3 = OR 1.09 [95% CI: 1.07, 1.11], and Q4 OR 1.05 [95% CI: 1.03, 1.07]).ConclusionsNeighborhood deprivation is an independent risk factor for mortality in persons with AD/ADRD.
Why it matters
Among Medicare beneficiaries with AD/ADRD, higher area deprivation index quartiles were associated with higher odds of all-cause mortality compared to the lowest quartile. The study identifies neighborhood deprivation as an independent risk factor for mortality, but does not test any treatment, cure, or prevention.
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Study details
- Effect sizeOR 1.08; OR 1.09; OR 1.05
- Evidence strengthModerate
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer s Disease) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 1 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jingchuan Serena Guo: h-index 22 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Pittsburgh: institution h-index 1,470 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40605436) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
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Read the original
- DOI: 10.1177/13872877251352120
- PubMed: 40605436
- Original source →
- Free full text: IUScholarWorks (Indiana University) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Paley, J. L., Scheiffele, G. D., Li, Y., Shaaban, C. E., Wu, Y., Anton, S. D., et al. (2025). Neighborhood deprivation and mortality among people with Alzheimer's disease and related dementia. Journal of Alzheimer s Disease. https://doi.org/10.1177/13872877251352120
Vancouver
Paley JL, Scheiffele GD, Li Y, Shaaban CE, Wu Y, Anton SD, et al. Neighborhood deprivation and mortality among people with Alzheimer's disease and related dementia. Journal of Alzheimer s Disease. 2025. doi:10.1177/13872877251352120. PMID: 40605436.
BibTeX
@article{paley2025-40605436,
author = {Paley, Joshua L. and Scheiffele, Grant D. and Li, Yujia and Shaaban, C. Elizabeth and Wu, Yonghui and Anton, Stephen Douglas and DeKosky, Steven T. and Bian, Jiang and others},
title = {{Neighborhood deprivation and mortality among people with Alzheimer's disease and related dementia}},
journal = {Journal of Alzheimer s Disease},
year = {2025},
doi = {10.1177/13872877251352120},
pmid = {40605436},
url = {https://doi.org/10.1177/13872877251352120}
}
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