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Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition
Yuxi Liu, Hailie Fowler, Dong D Wang, Lisa L Barnes, Marilyn C Cornelis. Nutrients, 2025-08-04
Topic: Genetics and APOE
Significant study-site, specimen type, and batch effects were observed. A total of 494 individuals of inferred European ancestry and 58 individuals of inferred African ancestry were included in the final imputed dataset. Evaluation of the imputed APOE genotype against gold-standard sequencing data showed high concordance (98.2%). We replicated several known genetic associations identified from previous genome-wide association studies, including SNPs previously linked to adiponectin (rs16861209, p = 1.5 × 10-5), alpha-linolenic acid (rs174547, p = 1.3 × 10-7), and alpha-tocopherol (rs964184, p = 0.003). This dataset represents the first genetic resource derived from a dietary intervention trial focused on cognitive outcomes. It enables investigation of genetic contributions to variability in cognitive response to the MIND diet and supports integrative analyses with other omics data types to elucidate the biological mechanisms underlying cognitive decline. These efforts may ultimately inform precision nutrition strategies to promote cognitive health.
Key findings
- Significant study-site, specimen type, and batch effects were observed.
- A total of 494 individuals of inferred European ancestry and 58 individuals of inferred African ancestry were included in the final imputed dataset.
- Evaluation of the imputed APOE genotype against gold-standard sequencing data showed high concordance (98.2%).
- We replicated several known genetic associations identified from previous genome-wide association studies, including SNPs previously linked to adiponectin (rs16861209, p = 1.5 × 10-5), alpha-linolenic acid (rs174547, p = 1.3 × 10-7), and alpha-tocopherol (rs964184, p = 0.003).
- This dataset represents the first genetic resource derived from a dietary intervention trial focused on cognitive outcomes.
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Study details
- Study designrandomized controlled trial
- Participants604
- Effect size98.2%
- Evidence strengthHigh
How this study scored 83/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and free to read, so those were left out: it earned 49 of the 59 points we could judge it on, which is 83 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nutrients) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 604 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40806132) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 49 / 59 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 49 of the 59 points we could judge it on is 83 out of 100. |
| Total | 83 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Liu, Y., Fowler, H., Wang, D. D., Barnes, L. L., & Cornelis, M. C. (2025). Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition. Nutrients. https://doi.org/10.3390/nu17152548
Vancouver
Liu Y, Fowler H, Wang DD, Barnes LL, Cornelis MC. Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition. Nutrients. 2025. doi:10.3390/nu17152548. PMID: 40806132.
BibTeX
@article{liu2025-40806132,
author = {Liu, Yuxi and Fowler, Hailie and Wang, Dong D and Barnes, Lisa L and Cornelis, Marilyn C},
title = {{Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Trial: Genetic Resource for Precision Nutrition}},
journal = {Nutrients},
year = {2025},
doi = {10.3390/nu17152548},
pmid = {40806132},
url = {https://doi.org/10.3390/nu17152548}
}