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Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging
Thomas Huntington Brown, Sarah‐Naomi James, Jennifer M. Nicholas, Sarah E Keuss, Ashvini Keshavan, Ian B. Malone, William Coath, Heidi Murray‐Smith et al.. Neurology, 2025-08-19
Topic: Brain proteins, microglia and lab models
< 0.1). -ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation. Although AD-specific pathology is typically considered the main cause of accelerated HAR, we demonstrated that HAR is also linked to deteriorating WM health. These results will need to be replicated in more diverse cohorts with longer follow-up periods to confirm the findings.
Key findings
- < 0.1). -ε4 status, and Aβ load, and not mediated by markers of neuroaxonal degradation.
- Although AD-specific pathology is typically considered the main cause of accelerated HAR, we demonstrated that HAR is also linked to deteriorating WM health.
- These results will need to be replicated in more diverse cohorts with longer follow-up periods to confirm the findings.
Why it matters
This population-based study found that increasing white matter hyperintensity volume was linked to faster hippocampal atrophy, independent of APOE4 status and amyloid load. The authors say the results need replication in more diverse cohorts, so no treatment or prevention is established.
Study details
- Evidence strengthLow
How this study scored 45/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Josephine Barnes: h-index 53 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40829101) |
| Free to read | 2 / 2 | Free to read |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Brown, T. H., James, S., Nicholas, J. M., Keuss, S. E., Keshavan, A., Malone, I. B., et al. (2025). Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging. Neurology. https://doi.org/10.1212/wnl.0000000000213975
Vancouver
Brown TH, James S, Nicholas JM, Keuss SE, Keshavan A, Malone IB, et al. Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging. Neurology. 2025. doi:10.1212/wnl.0000000000213975. PMID: 40829101.
BibTeX
@article{brown2025-40829101,
author = {Brown, Thomas Huntington and James, Sarah‐Naomi and Nicholas, Jennifer M. and Keuss, Sarah E and Keshavan, Ashvini and Malone, Ian B. and Coath, William and Murray‐Smith, Heidi and others},
title = {{Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000213975},
pmid = {40829101},
url = {https://doi.org/10.1212/wnl.0000000000213975}
}
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