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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Vascular contributions

Topic: Risk, prevention and care in population studies

1. Neuropsychological assessments indicated that the CSVD group scored significantly lower than the HC group in general cognitive level, memory, visuospatial ability, executive function, and language function (p < 0.05). 2. In resting-state EEG microstate analysis, the CSVD group exhibited significantly lower appearance rates for MsA, MsB, MsC, and MsD compared to the HC group (p = 0.014, p = 0.047, p = 0.014, p = 0.02). Durations of MsB, MsC, and MsD were prolonged in the CSVD group (p = 0.014, p = 0.037, p = 0.036). Furthermore, the MsC to MsA transition rate was significantly reduced in the CSVD group (p = 0.036). 3. Correlation analysis within the CSVD group revealed several significant relationships. The MsD to MsC transition rate was negatively correlated with the AD8 score (p = 0.049, r = - 0.309). The MsD occurrence rate was negatively correlated with the FAQ score (p = 0.039, r = - 0.324). The MsA to MsC transition rate was positively correlated with the FAQ score (p = 0.038, r = 0.326). The MsD occurrence rate was positively correlated with MMSE (p = 0.027, r = 0.345). The MsA to MsB transition rate was negatively correlated with MMSE (p = 0.041, r = - 0.321). The MsB duration was negatively correlated with DST scores (p = 0.027, r = - 0.345). The MsD occurrence was positively correlated with BNT scores (p = 0.031, r = 0.338). MsA coverage, MsA to MsB transition rate, and MsB to MsA transition rate were negatively correlated with Stroop C scores [(p = 0.019, r = - 0.364), (p = 0.01, r = - 0.399), (p = 0.022, r = - 0.358)]. The MsC to MsD transition rate and MsD to MsC transition rate were positively correlated with the Stroop C score [(p = 0.014, r = 0.381), (p = 0.01, r = 0.397)]. The CSVD group demonstrated increased stability in brain functional networks but reduced inter-network interaction capabilities. Network activities related to MsA and MsB were enhanced, while those related to MsC were diminished. Abnormal changes in microstates were correlated with cognitive deficits in CSVD patients, suggesting that microstate alterations could serve as potential biomarkers for CSVD-related cognitive impairment.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Jin, X., Zhou, Y., Zhang, D., Xiu, C., Ruan, J., & Fang, D. (2025). Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates. European journal of medical research. https://doi.org/10.1186/s40001-025-03037-w

Vancouver

Jin X, Zhou Y, Zhang D, Xiu C, Ruan J, Fang D. Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates. European journal of medical research. 2025. doi:10.1186/s40001-025-03037-w. PMID: 40841915.

BibTeX

@article{jin2025-40841915,
  author  = {Jin, Xin and Zhou, Yanru and Zhang, Diwen and Xiu, Chen and Ruan, Jianghai and Fang, Dengfu},
  title   = {{Analysis of brain dynamics changes in patients with cerebral small vessel disease-related cognitive impairment based on electroencephalogram microstates}},
  journal = {European journal of medical research},
  year    = {2025},
  doi     = {10.1186/s40001-025-03037-w},
  pmid    = {40841915},
  url     = {https://doi.org/10.1186/s40001-025-03037-w}
}

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Key findings

Neuropsychological assessments indicated that the CSVD group scored significantly lower than the HC group in general cognitive level, memory, visuospatial ability, executive function, and language function (p < 0.05). 2.
In resting-state EEG microstate analysis, the CSVD group exhibited significantly lower appearance rates for MsA, MsB, MsC, and MsD compared to the HC group (p = 0.014, p = 0.047, p = 0.014, p = 0.02).
Durations of MsB, MsC, and MsD were prolonged in the CSVD group (p = 0.014, p = 0.037, p = 0.036).
Furthermore, the MsC to MsA transition rate was significantly reduced in the CSVD group (p = 0.036). 3.
Correlation analysis within the CSVD group revealed several significant relationships.

Why it matters

This study found that patients with cerebral small vessel disease-related cognitive impairment scored lower on cognitive tests and showed different resting-state EEG microstate patterns compared to healthy controls. These EEG measures were correlated with cognitive scores, but the study does not test any treatment, cure, or prevention.

Study details

Participants40
Evidence strengthModerate

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 39 of the 96 points we could judge it on, which is 41 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (European journal of medical research)
Journal's citation record	1 / 4	European journal of medical research: journal h-index 80 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	40 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.7× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	0 / 3	Southwest Medical University: institution h-index 240 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40841915)
Free to read	2 / 2	Free to read
Points	39 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 39 of the 96 points we could judge it on is 41 out of 100.
Total	41 / 100	—

What each of these 20 components measures, and what this score is not →

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