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Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies
Aline Delva, Cinzia Zatti, Amélie Pelletier, Jacques Montplaisir, Jean-François Gagnon, Gwendlyn Kollmorgen, Tony Kam-Thong, Thomas Kustermann et al.. Movement disorders : official journal of the Movement Disorder Society, 2025-08-21
Topic: Brain imaging, connectivity and assessment
A total of 143 iRBD participants (110 male, 67.7 ± 8.0 years) were included. Compared with non-phenoconverters, DLB-converters had higher baseline GFAP (0.115 vs. 0.071 ng/ml, P = 0.002) and NfL (3.55 vs. 2.51 pg/ml, P = 0.010). Baseline levels predicted DLB using non-phenoconverters without mild cognitive impairment as reference with area under the curve (AUC) = 0.79 for GFAP and 0.84 for NfL. Higher plasma GFAP and NfL were associated with increased risk of developing DLB in prodromal synucleinopathies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Key findings
- A total of 143 iRBD participants (110 male, 67.7 ± 8.0 years) were included.
- Compared with non-phenoconverters, DLB-converters had higher baseline GFAP (0.115 vs. 0.071 ng/ml, P = 0.002) and NfL (3.55 vs. 2.51 pg/ml, P = 0.010).
- Baseline levels predicted DLB using non-phenoconverters without mild cognitive impairment as reference with area under the curve (AUC) = 0.79 for GFAP and 0.84 for NfL.
- Higher plasma GFAP and NfL were associated with increased risk of developing DLB in prodromal synucleinopathies. © 2025 The Author(s).
- Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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Study details
- Study designcohort study
- Participants2,004
- Evidence strengthModerate
How this study scored 70/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Movement disorders : official journal of the Movement Disorder Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,004 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40879604) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
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APA 7th
Delva, A., Zatti, C., Pelletier, A., Montplaisir, J., Gagnon, J.-F., Kollmorgen, G., et al. (2025). Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies. Movement disorders : official journal of the Movement Disorder Society. https://doi.org/10.1002/mds.70016
Vancouver
Delva A, Zatti C, Pelletier A, Montplaisir J, Gagnon J.-F, Kollmorgen G, et al. Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies. Movement disorders : official journal of the Movement Disorder Society. 2025. doi:10.1002/mds.70016. PMID: 40879604.
BibTeX
@article{delva2025-40879604,
author = {Delva, Aline and Zatti, Cinzia and Pelletier, Amélie and Montplaisir, Jacques and Gagnon, Jean-François and Kollmorgen, Gwendlyn and Kam-Thong, Tony and Kustermann, Thomas and others},
title = {{Plasma Markers of Astrocytic and Axonal Integrity in Idiopathic/Isolated REM Sleep Behavior Disorder (iRBD) as Predictors of Dementia with Lewy Bodies}},
journal = {Movement disorders : official journal of the Movement Disorder Society},
year = {2025},
doi = {10.1002/mds.70016},
pmid = {40879604},
url = {https://doi.org/10.1002/mds.70016}
}