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Electroencephalography‐based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high‐risk for progression to dementia
Chiara Pappalettera, Lorenzo Nucci, Alessia Cacciotti, Fabrizio Vecchio, Camillo Marra, Naike Caraglia, Davide Quaranta, Stefano Francesco Cappa et al.. Alzheimer s & Dementia Translational Research & Clinical Interventions, 2025-10-01
Topic: Risk, prevention and care in population studies
Compared with sMCI-resilient subjects, cMCI individuals exhibited increased frontal delta power, reduced posterior alpha power, and an elevated delta/alpha ratio in the right temporal region, consistent with cortical dysfunction. In contrast, sMCI-resilient subjects showed stronger frontal and temporal alpha-band connectivity and higher small-world (SW) index values in the alpha-2 band, suggesting more efficient network organization. Specific EEG signatures-characterized by adaptive spectral patterns, preserved connectivity, and efficient network topology-may represent neurophysiological correlates of resilience in high-risk MCI. These findings highlight the potential of EEG markers for early intervention and stratification strategies in individuals at risk of dementia. Highlights: Electroencephalography (EEG) markers differentiate resilience and progression in mild cognitive impairment (MCI) individuals with high-risk biomarker profiles.Converters (cMCI) show increased delta power, reduced alpha activity, and higher delta/alpha ratios, indicating cortical dysfunction.Resilient MCI (sMCI) maintain healthy delta profiles, enhanced frontal alpha power, and stronger anterior connectivity.Graph-theoretical analysis reveals higher small-world (SW) index in resilient MCI, suggesting efficient and flexible network organization.EEG is a non-invasive, accessible tool to capture both risk and resilience factors, with potential for early diagnosis and personalized interventions.
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APA 7th
Pappalettera, C., Nucci, L., Cacciotti, A., Vecchio, F., Marra, C., Caraglia, N., et al. (2025). Electroencephalography‐based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high‐risk for progression to dementia. Alzheimer s & Dementia Translational Research & Clinical Interventions. https://doi.org/10.1002/trc2.70194
Vancouver
Pappalettera C, Nucci L, Cacciotti A, Vecchio F, Marra C, Caraglia N, et al. Electroencephalography‐based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high‐risk for progression to dementia. Alzheimer s & Dementia Translational Research & Clinical Interventions. 2025. doi:10.1002/trc2.70194. PMID: 41425085.
BibTeX
@article{pappalettera2025-41425085,
author = {Pappalettera, Chiara and Nucci, Lorenzo and Cacciotti, Alessia and Vecchio, Fabrizio and Marra, Camillo and Caraglia, Naike and Quaranta, Davide and Cappa, Stefano Francesco and others},
title = {{Electroencephalography‐based signatures of cognitive resilience in individuals with stable mild cognitive impairment despite carrying a high‐risk for progression to dementia}},
journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
year = {2025},
doi = {10.1002/trc2.70194},
pmid = {41425085},
url = {https://doi.org/10.1002/trc2.70194}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Compared with sMCI-resilient subjects, cMCI individuals exhibited increased frontal delta power, reduced posterior alpha power, and an elevated delta/alpha ratio in the right temporal region, consistent with cortical dysfunction.
- In contrast, sMCI-resilient subjects showed stronger frontal and temporal alpha-band connectivity and higher small-world (SW) index values in the alpha-2 band, suggesting more efficient network organization.
- Specific EEG signatures-characterized by adaptive spectral patterns, preserved connectivity, and efficient network topology-may represent neurophysiological correlates of resilience in high-risk MCI.
- These findings highlight the potential of EEG markers for early intervention and stratification strategies in individuals at risk of dementia.
- Highlights: Electroencephalography (EEG) markers differentiate resilience and progression in mild cognitive impairment (MCI) individuals with high-risk biomarker profiles.Converters (cMCI) show increased delta power, reduced alpha activity, and higher delta/alpha ratios, indicating cortical dysfunction.Resilient MCI (sMCI) maintain healthy delta profiles, enhanced frontal alpha power, and stronger anterior connectivity.Graph-theoretical analysis reveals higher small-world (SW) index in resilient MCI, suggesting efficient and flexible network organization.EEG is a non-invasive, accessible tool to capture both risk and resilience factors, with potential for early diagnosis and personalized interventions.
Why it matters
This study found that people with mild cognitive impairment who stayed stable despite high-risk biomarker profiles showed different EEG patterns, including stronger alpha-band connectivity and more efficient network organization, than those who progressed. These EEG markers may help identify who is at risk of dementia and guide early intervention, though the study does not test any treatment.
Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia Translational Research & Clinical Interventions) |
| Journal's citation record | 1 / 4 | Alzheimer s & Dementia Translational Research & Clinical Interventions: journal h-index 84 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Paolo Maria Rossini: h-index 15 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | IRCCS Ospedale San Raffaele: institution h-index 731 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 13 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41425085) |
| Free to read | 2 / 2 | Free to read |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1002/trc2.70194
- PubMed: 41425085
- Original source →
- Free full text: Alzheimer s & Dementia Translational Research & Clinical Interventions →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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