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Cardiovascular risk factors and the allostatic interoceptive network in dementia
Jessica L. Hazelton, Joaquín Migeot, Raúl González-Gómez, Florencia Altschuler, Claudia A. Duran-Aniotz, Olivia Wen, Dante Sebastián Galván Galván Rial, Pablo Barttfeld et al.. Cardiovascular Research, 2025-10-01
Topic: Risk, prevention and care in population studies
We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat). A cardiovascular risk score was calculated based on: age, sex, diabetes, hypertension, systolic blood pressure, body mass index, and smoking status. Cardiovascular risk was associated with grey matter integrity and functional connectivity in age- and sex-matched patient-control groups focusing on predefined regions of interest within the AIN. Higher cardiovascular risk was associated with reduced structural integrity and functional connectivity within the AIN in both FTLD and AD. FTLD patients showed more extensive structural and functional connectivity disruptions throughout the AIN. In AD patients, structural reductions in the AIN were prominent, with functional connectivity restricted to the hippocampus, parahippocampal gyrus, and orbitofrontal regions. Cardiovascular risk factors appear to adversely impact the AIN structure and function, with disease-specific patterns of vulnerability. Results underscore the importance of integrating cardiovascular health into models of neurodegenerative disease and managing cardiovascular health to support brain integrity in dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hazelton, J. L., Migeot, J., González-Gómez, R., Altschuler, F., Duran-Aniotz, C. A., Wen, O., et al. (2025). Cardiovascular risk factors and the allostatic interoceptive network in dementia. Cardiovascular Research. https://doi.org/10.1093/cvr/cvaf185
Vancouver
Hazelton JL, Migeot J, González-Gómez R, Altschuler F, Duran-Aniotz CA, Wen O, et al. Cardiovascular risk factors and the allostatic interoceptive network in dementia. Cardiovascular Research. 2025. doi:10.1093/cvr/cvaf185. PMID: 41073365.
BibTeX
@article{hazelton2025-41073365,
author = {Hazelton, Jessica L. and Migeot, Joaquín and González-Gómez, Raúl and Altschuler, Florencia and Duran-Aniotz, Claudia A. and Wen, Olivia and Rial, Dante Sebastián Galván Galván and Barttfeld, Pablo and others},
title = {{Cardiovascular risk factors and the allostatic interoceptive network in dementia}},
journal = {Cardiovascular Research},
year = {2025},
doi = {10.1093/cvr/cvaf185},
pmid = {41073365},
url = {https://doi.org/10.1093/cvr/cvaf185}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat).
- A cardiovascular risk score was calculated based on: age, sex, diabetes, hypertension, systolic blood pressure, body mass index, and smoking status.
- Cardiovascular risk was associated with grey matter integrity and functional connectivity in age- and sex-matched patient-control groups focusing on predefined regions of interest within the AIN.
- Higher cardiovascular risk was associated with reduced structural integrity and functional connectivity within the AIN in both FTLD and AD.
- FTLD patients showed more extensive structural and functional connectivity disruptions throughout the AIN.
Why it matters
In 1501 participants with frontotemporal dementia, Alzheimer's disease, or healthy controls, higher cardiovascular risk was associated with reduced structural integrity and functional connectivity in the allostatic interoceptive network. The authors conclude that managing cardiovascular health may support brain integrity in dementia, but the study did not test whether this prevents or treats Alzheimer's disease.
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Study details
- Participants1,501
- Evidence strengthLow
How this study scored 51/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cardiovascular Research) |
| Journal's citation record | 3 / 4 | Cardiovascular Research: journal h-index 299 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,501 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Agustín M. Ibáñez: h-index 81 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 32 institution(s) in 11 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41073365) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/cvr/cvaf185
- PubMed: 41073365
- Original source →
- Free full text: Cardiovascular Research →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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