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Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias
Juan Antonio K. Chong Chie, Scott A. Persohn, Ravi S. Pandey, G. W. Carter, Olivia R. Simcox, Paul Salama, Paul R. Territo, for the Alzheimer's Disease Neuroimaging Initiative. Alzheimer s & Dementia, 2025-11-01
Topic: Amyloid, tau and blood-test diagnosis
Our findings suggest that disease progression follows a stage-dependent MVD pattern that can identify at-risk regions. Although each region progresses at a different pace, regions related to memory, cognition, and motor function showed significant early dysregulation. Importantly, these changes aligned with transcriptomic and cognitive signatures. This study underscores that MVD in brain regions varies by sex and disease stage, making it a sensitive tool for early AD diagnosis. This approach could improve patient monitoring, stratification, and therapeutic testing. HIGHLIGHTS: The potential of metabolic and vascular dysfunction as an early biomarker was assessed. An analytical method to assess dysregulation via imaging was developed. An analytical and graphical method to visualize the changes across disease spectrum was developed. Brain regions progress at different rates across Alzheimer's disease progression. Results were aligned with transcriptomics and cognitive signatures.
Key findings
- Our findings suggest that disease progression follows a stage-dependent MVD pattern that can identify at-risk regions.
- Although each region progresses at a different pace, regions related to memory, cognition, and motor function showed significant early dysregulation.
- Importantly, these changes aligned with transcriptomic and cognitive signatures.
- This study underscores that MVD in brain regions varies by sex and disease stage, making it a sensitive tool for early AD diagnosis.
- This approach could improve patient monitoring, stratification, and therapeutic testing.
Why it matters
This study suggests that metabolic and vascular dysfunction in the brain varies by sex and disease stage and could serve as an early diagnostic tool for Alzheimer's disease. It may help improve patient monitoring, stratification, and therapeutic testing, but the findings are based on imaging and analytical methods that require further validation.
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Study details
- Participants403
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 44 of the 96 points we could judge it on, which is 46 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 403 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 10 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 6.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Indiana University School of Medicine: institution h-index 784 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41201009) |
| Free to read | 2 / 2 | Free to read |
| Points | 44 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 44 of the 96 points we could judge it on is 46 out of 100. |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Chie, J. A. K. C., Persohn, S. A., Pandey, R. S., Carter, G. W., Simcox, O. R., Salama, P., et al. (2025). Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias. Alzheimer s & Dementia. https://doi.org/10.1002/alz.70790
Vancouver
Chie JAKC, Persohn SA, Pandey RS, Carter GW, Simcox OR, Salama P, et al. Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias. Alzheimer s & Dementia. 2025. doi:10.1002/alz.70790. PMID: 41201009.
BibTeX
@article{chie2025-41201009,
author = {Chie, Juan Antonio K. Chong and Persohn, Scott A. and Pandey, Ravi S. and Carter, G. W. and Simcox, Olivia R. and Salama, Paul and Territo, Paul R. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias}},
journal = {Alzheimer s \& Dementia},
year = {2025},
doi = {10.1002/alz.70790},
pmid = {41201009},
url = {https://doi.org/10.1002/alz.70790}
}
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