Newest studies

Flavonoids as Potential Anti-Inflammatory Molecules: A Review

43/100 ✓ Peer-reviewed Inflammation and the immune system Molecules (Basel, Switzerland)

Key finding: Studies show that flavonoids activate antioxidant pathways that render an anti-inflammatory effect. +4 more findings

• Brain Biology

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Longitudinal Changes in Hearing and Visual Impairments and Risk of Dementia in Older Adults in the United States

70/100 ✓ Peer-reviewed Disparities JAMA network open

Key finding: Compared with no sensory impairment, DSI was associated with increased risk of all-cause dementia (hazard ratio [HR], 2.60; 95% CI, 1.66-2.06; P Conclusions and relevance In this cohort study, DSI was associated with increased risk of dementia, particularly AD. +4 more findings

• Risk Factors

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Association of Dual Decline in Cognition and Gait Speed With Risk of Dementia in Older Adults

78/100 ✓ Peer-reviewed Disparities JAMA network open

Key finding: Of 19 114 randomized participants, 16 855 (88.2%) had longitudinal gait and cognitive data for inclusion in this study (mean [SD] age, 75.0 [4.4] years; 9435 women [56.0%], 7558 participants [44.8%] with 12 or more years of education). +4 more findings

• Risk Factors

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Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome

78/100 ✓ Peer-reviewed Disparities JAMA network open

Key finding: The variability in disease onset was compared with that of autosomal dominant Alzheimer disease. +4 more findings

• Down Syndrome

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Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression

66/100 ✓ Peer-reviewed Long-term cohort studies JAMA psychiatry

Key finding: Late-life depression (LLD) is characterized by considerable heterogeneity in clinical manifestation. +3 more findings

• Genetics

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Caregiving Burden Among Caregivers of People With Dementia Through the Lens of Intersectionality

45/100 ✓ Peer-reviewed Disparities The Gerontologist

Key finding: Surprisingly, compared to White female caregivers, all the other groups were 37% (95% CI 0.41-0.95) to 71% (95% CI 0.15-0.56) less likely to have emotional burden. +1 more finding

• Health Equity
• Caregiving

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Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US

54/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: These findings suggest that at current expected prices, neither aducanumab nor donanemab would be cost-effective for early AD in the US. +1 more finding

• Policy
• Treatments
• Clinical Trials

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Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies

64/100 ✓ Peer-reviewed Prevention and risk European journal of preventive cardiology

Key finding: These results confirm the absence of a neurocognitive risk associated with statin treatment and suggest a potential favourable role of statins. +4 more findings

• Risk Factors

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Gut Microbiota Modification via Glucagon-like Peptide-1 with Beneficial Neuroprotective Effects

70/100 ✓ Peer-reviewed Drug development Middle East journal of digestive diseases

Key finding: The results showed that intestinal expression of GLP-1 1 could reduce the intestinal pathogenic genus such as Enterobacteriaceae and was obviously associated with a greater number of beneficial genera such as Lactobacillus and Akkermansia. +3 more findings

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Plasma Phosphorylated-tau181 Is a Predictor of Post-stroke Cognitive Impairment: A Longitudinal Study

70/100 ✓ Peer-reviewed Biomarkers Frontiers in Aging Neuroscience

Key finding: Of 136 patients, 40 and 50 patients developed PSCI at 3 and 12 months after stroke, respectively. +4 more findings

• Biomarkers

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Dyadic Enrollment in a Phase 3 Mild Cognitive Impairment Clinical Trial

48/100 ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders

Key finding: Among 769 randomized dyads, 73% were spousal, 14% adult child, and 13% other dyads. +1 more finding

• Clinical Trials
• Health Equity
• Early Stage

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Susac syndrome: challenges in the diagnosis and treatment

45/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology

Key finding: Third, in many cases, Susac syndrome is diagnosed and treated late, with significant irreversible sequelae including dementia, blindness and hearing loss.

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Molecular recognition of the interaction between ApoE and the TREM2 protein

41/100 ✓ Peer-reviewed Genetics Translational neuroscience

Key finding: The results indicate that the binding energy between ApoE and TREM2 occurs in an isoform-dependent manner with the following potency rank order: ApoE4 > ApoE3 > ApoE2. +1 more finding

• Genetics

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Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

43/100 ✓ Peer-reviewed Brain scans and imaging Microbiome

Key finding: These findings demonstrate that the aging gut microbiota drives detrimental changes in the gut-brain and gut-retina axes suggesting that microbial modulation may be of therapeutic benefit in preventing inflammation-related tissue decline in later life. +3 more findings

• Brain Biology

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Determinants of technology adoption and continued use among cognitively impaired older adults: a qualitative study

44/100 ✓ Peer-reviewed Health systems and care delivery BMC geriatrics

Key finding: Future research is encouraged to validate our findings in a postpandemic era and to further develop a novel theoretical framework for technology acceptance among older adults with cognitive impairments.

• Digital Tools

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Comparing the care experiences of Medicare Advantage beneficiaries with and without Alzheimer's disease and related dementias

43/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Among beneficiaries sampled by CAHPS, 22.2% with ADRD completed the survey compared to 38.5% without ADRD. +4 more findings

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Therapeutic news in Alzheimer's disease: Soon a disease-modifying therapy?

41/100 ✓ Peer-reviewed Treatments Revue neurologique

Key finding: However, in the last three years, four molecules have shown significant effects on clinical endpoints in phase II or III clinical trials (i.e., slowing of cognitive decline). +1 more finding

• Treatments
• Brain Biology

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The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health

59/100 ✓ Peer-reviewed Genetics Nature aging

Key finding: The brain regions most significantly underlying this interconnection included the precentral cortex, the lateral orbitofrontal cortex and the hippocampus. +2 more findings

• Genetics
• Lifestyle

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Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort

52/100 ✓ Peer-reviewed Cognitive tests and assessment EClinicalMedicine

Key finding: The pattern of deficits across tasks was qualitatively compared with normal age-related decline, and early-stage dementia. +2 more findings

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Structural progression of Alzheimer's disease over decades: the MRI staging scheme

67/100 ✓ Peer-reviewed Disease mechanisms Brain communications

Key finding: We concluded that this MRI scheme of atrophy progression in Alzheimer's disease was close but did not entirely overlap with Braak staging of tauopathy, with a 'reverse chronology' between limbic and entorhinal stages. +1 more finding

• Brain Scans

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Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis

48/100 ✓ Peer-reviewed TREM2 and immune genetics Arteriosclerosis, thrombosis, and vascular biology

Key finding: Cholesterol loaded macrophage foam cells are a prominent feature of atherosclerotic plaques. +3 more findings

• Genetics
• Brain Biology

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Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway

41/100 ✓ Peer-reviewed Inflammation and the immune system Aging cell

Key finding: However, the precise molecular mechanism through which the NLRP3 inflammasome is associated with AD pathologies remains unclear. +2 more findings

• Brain Biology
• Treatments

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The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish

41/100 ✓ Peer-reviewed Genetics HGG advances

Key finding: Although APOE ε4 remains the largest genetic risk factor for AD, more than 26 other loci have been associated with AD risk. +2 more findings

• Genetics

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Serum GFAP differentiates Alzheimer's disease from frontotemporal dementia and predicts MCI-to-dementia conversion

55/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

Key finding: In total, samples from 610 individuals from four clinical centres were investigated in this study. +4 more findings

• Biomarkers
• Early Stage

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The Effect of Transcranial Alternating Current Stimulation With Cognitive Training on Executive Brain Function in Individuals With Dementia: Protocol for a Crossover Randomized Controlled Trial

45/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: We anticipate that transcranial alternating current stimulation will be a well-tolerated treatment, with no serious side effects and with considerable short- and long-term cognitive improvements. +1 more finding

• Clinical Trials

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