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Using retinal diagnostics as a biomarker for neurodegenerative diseases: protocol for a systematic review
Zeynep Sahin-Lodge, Sara Pisani, Paul Nderitu, Ta-Wei Guu, Dag Aarsland, Timothy L Jackson, Dominic Ffytche, Ashwin V Venkataraman. BMJ open, 2025-11-13
Topic: Plasma and spinal-fluid biomarkers
A narrative synthesis approach will be used to analyse the results, with meta-analysis performed if there is sufficient data.
Key findings
- A narrative synthesis approach will be used to analyse the results, with meta-analysis performed if there is sufficient data.
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Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 71/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 40 of the 56 points we could judge it on, which is 71 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMJ open) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41248418) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 40 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 40 of the 56 points we could judge it on is 71 out of 100. |
| Total | 71 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Sahin-Lodge, Z., Pisani, S., Nderitu, P., Guu, T.-W., Aarsland, D., Jackson, T. L., et al. (2025). Using retinal diagnostics as a biomarker for neurodegenerative diseases: protocol for a systematic review. BMJ open. https://doi.org/10.1136/bmjopen-2025-106531
Vancouver
Sahin-Lodge Z, Pisani S, Nderitu P, Guu T.-W, Aarsland D, Jackson TL, et al. Using retinal diagnostics as a biomarker for neurodegenerative diseases: protocol for a systematic review. BMJ open. 2025. doi:10.1136/bmjopen-2025-106531. PMID: 41248418.
BibTeX
@article{sahinlodge2025-41248418,
author = {Sahin-Lodge, Zeynep and Pisani, Sara and Nderitu, Paul and Guu, Ta-Wei and Aarsland, Dag and Jackson, Timothy L and Ffytche, Dominic and Venkataraman, Ashwin V},
title = {{Using retinal diagnostics as a biomarker for neurodegenerative diseases: protocol for a systematic review}},
journal = {BMJ open},
year = {2025},
doi = {10.1136/bmjopen-2025-106531},
pmid = {41248418},
url = {https://doi.org/10.1136/bmjopen-2025-106531}
}
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