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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 76–100 of 27,380 studies, newest first · page 4 of 1096.

October 2026 25

  1. 2026-10-24

    Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons

    ⚠ Preprint — not yet peer-reviewed Risk genes beyond APOE bioRxiv

    Key finding: To identify early, cell-autonomous phenotypes associated with AD, we used isogenic KOLF2.1J iPSC-derived NGN2 neurons (iNeurons) carrying a heterozygous or homozygous APP-London mutation (V717I) and conducted a longitudinal proteomic study. +3 more findings

    Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  2. 2026-10-24

    Genetic susceptibility to Lewy body disease and the distribution of Lewy pathology

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: Across all cases, the SNCA association was indexed by a 5′ signal previously associated with dementia with Lewy bodies and rapid eye movement sleep behaviour disorder, rather than the canonical 3′ Parkinson’s disease variant. +3 more findings

    Scored 61 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  3. 2026-10-24

    A digital biomarker of white-matter routing from diffusion MRI as an early biomarker of Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

    Key finding: Because white-matter structure is altered early, we computed two graph-theoretic indices of periventricular white-matter routing from diffusion MRI in 1,706 OASIS-3 sessions: the Route Concordance Index (RCI), a population-calibrated path-concordance score over 316 routes, and a global conductance from the connectome’s graph Laplacian. +4 more findings

    Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  4. 2026-10-24

    Plasma eMTBR-tau as a marker of clinical stage and progression across the Alzheimer’s disease continuum

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Plasma eMTBR-tau243 has been associated with tau pathology and cognitive decline. +2 more findings

    Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  5. 2026-10-24

    Plasma Proteomic Correlates of Cognitive Function in Older Adults From Central Africa

    ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

    Key finding: Key Points Question Which candidate plasma proteins are associated with cognitive performance across multiple domains in older adults from the Democratic Republic of Congo? +4 more findings

    Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  6. 2026-10-23

    A coordinated and reproducible multicellular response to AD pathology

    ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology bioRxiv

    Key finding: Operationalization of these findings requires a multi-cellular model of AD that is robust and reproducible. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  7. 2026-10-23

    Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer’s disease susceptibility

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system Research Square

    Key finding: Together, these findings demonstrate that maternal microbial inheritance and developmental timing critically shape sex specific AD susceptibility and position temporal microbiome modulation as a potential precision strategy for disease prevention.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  8. 2026-10-23

    Pantethine and Neurodegeneration: A Coenzyme A-Centered Framework Linking Metabolism, Neuroinflammation, and Mitochondrial Dysfunction

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system Preprints.org

    Key finding: Neurodegenerative diseases are a growing global health burden associated with aging and characterized by progressive neuronal dysfunction, metabolic failure, mitochondrial impairment, oxidative stress, and chronic neuroinflammation.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  9. 2026-10-23

    Prognostic heterogeneity within cognitive stages: a nationwide cohort study of everyday functional difficulties and mortality in 202,508 older adults

    ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

    Key finding: Cognitive staging and everyday function are not interchangeable.

    Scored 50 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  10. 2026-10-23

    MVMGNN: Multi-View Masked Graph Neural Network for Alzheimer’s Disease Diagnosis using Structural MRI

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

    Key finding: Experimental results on the ADNI dataset demonstrate that MVMGNN achieves competitive performance compared with existing methods across AD-related classification tasks. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  11. 2026-10-23

    Associations of genetic predisposition to Alzheimer’s disease with blood-based biomarkers: a community-based study

    ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

    Key finding: The blood-based biomarker (BBM) profiles associated with genetic susceptibility to Alzheimer’s disease (AD) in general older populations remain poorly understood. +2 more findings

    Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  12. 2026-10-22

    Optimizing Cognitive Phenotyping for Genetic Discovery in Alzheimer’s Disease: A Simulation-Based Evaluation of Mini-Mental State Examination-Based Decline Measures

    ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment bioRxiv

    Key finding: The phenotypic measures “Slope” and “dMMSE/dt” consistently showed strong performance across a range of data distributions, while “Time-to-MMSE10” was particularly effective in cohorts with a higher proportion of individuals experiencing severe cognitive decline. +1 more finding

    Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  13. 2026-10-22

    Frequency-Resolved Connectivity Graphs for EEG-Based Classification of Alzheimer and Frontotemporal Dementia

    ⚠ Preprint — not yet peer-reviewed Lewy body dementia bioRxiv

    Key finding: With leave-one-subject-out (LOSO) validation, the model reaches an accuracy of 81.13% for AD vs CN and 76.06% for FTD vs CN, which is competitive with the baselines reported with the dataset with far fewer parameters (159 and 282 thousand versus 170.5 million).

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  14. 2026-10-22

    Prevalence of dementia and mild cognitive impairment in Morocco: A population-based study

    ⚠ Preprint — not yet peer-reviewed Disparities Research Square

    Key finding: This nationwide study provides epidemiological data on dementia and MCI among adults aged ≥ 60 years across all 12 administrative regions of Morocco.

    Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  15. 2026-10-22

    GPR6 Protects Medial Entorhinal Cortex in 5×FAD Mice from Early Pathology in Alzheimer’s Disease

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system Research Square

    Key finding: In vivo two-photon calcium imaging further revealed MEC layer II/III network hyperactivity in 5×FAD mice, together with disrupted spatial and directional coding. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  16. 2026-10-22

    Early Insulin Signaling Abnormalities and Oxidative Stress Responses in PS19 Tau Transgenic Mice

    ⚠ Preprint — not yet peer-reviewed Inflammation and the immune system bioRxiv

    Key finding: We found that alterations in phospho-IRS1, phospho-IRβ, and the glucose transporters GLUT3 and GLUT4 occur before pathogenic tau deposition. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  17. 2026-10-22

    Heat-related mortality by comorbidity and cause of death: a time-stratified case-crossover study of 3.7 million deaths in Brazil, 2014–2025

    ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

    Key finding: Because deaths without a given condition differ in cause composition from deaths with it, each condition was also compared with deaths carrying another of the studied conditions: the dementia estimate strengthened to 1.050 (1.036–1.065), and cerebrovascular disease reached 1.018 (1.009–1.027), a smaller but statistically robust positive modification. +1 more finding

    Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  18. 2026-10-22

    Amyloid and Tau Neuropathologic Stage, Coexisting Brain Disease, and Cognitive Status in a Population-Based Autopsy Cohort

    ⚠ Preprint — not yet peer-reviewed Clinical trials medRxiv

    Key finding: Among 2711 decedents (mean [SD] age, 73.4 [14.4] years; range, 23 to 111 years; 1340 [49.4%] female), 531 (19.6%) met both thresholds, 270 (10.0%) the amyloid threshold only, 207 (7.6%) the tau threshold only, and 1703 (62.8%) neither. +2 more findings

    Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  19. 2026-10-22

    Retinal biomarkers and dementia risk: A review of evidence across the 14 Lancet modifiable risk factors for dementia

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging PsyArXiv

    Key finding: Quantitative retinal measures can be derived at scale and have been associated with mechanistic processes in the brain and throughout the body, positioning retinal biomarkers as promising tools for dementia prevention and intervention research. +2 more findings

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  20. 2026-10-22

    A Dual-Stream Spatio-Temporal Network with Bidirectional Rectification for Differential Diagnosis of Dementia using EEG

    ⚠ Preprint — not yet peer-reviewed Brain scans and imaging Research Square

    Key finding: Experimental results on the ADFTD-RS dataset show that the proposed framework yields a subject-level accuracy of 60.00\% and an F1-score of 57.44\%, showing measurable improvements over several baseline methods.

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  21. 2026-10-22

    Genetic Modifiers of Age at Onset for Parkinson’s Disease in European Populations

    ⚠ Preprint — not yet peer-reviewed Genetics medRxiv

    Key finding: This study represents the largest PD AAO meta-analysis in European-ancestry populations to date. +4 more findings

    Scored 58 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  22. 2026-10-22

    α-Synuclein Seed Amplification Status Modifies the Relationship Between Plasma p-tau217, Amyloid and Fibrillar Tau

    ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

    Key finding: Plasma p-tau217 is elevated in αSynSAA-positive individuals at equivalent AD pathology measured by amyloid PET or the CSF ratio, and this elevation is attenuated most by fibrillar tau. +1 more finding

    Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2026-10-22

    Soluble amyloid composition links proximal APP processing, fibrillar burden and the p-tau181 response

    ⚠ Preprint — not yet peer-reviewed Biomarkers Research Square

    Key finding: D42 was preferentially associated with later fibrillar burden: among 91 participants with PET a median 4.98 years later, the D42–T contrast was 31.21 Centiloids/SD (95% CI 11.12–51.30). +3 more findings

    Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  24. 2026-10-21

    Speaker-Wise Dementia Screening fromNaturalistic Speech with Lexical Entropy, Semantic Drift, and Multimodal Fusion

    ⚠ Preprint — not yet peer-reviewed Digital health tools Research Square

    Key finding: Although advances have been made in dementia symptom management, early detection during stages when interventions are most effective remains a significant challenge. +3 more findings

    Scored 40 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2026-10-21

    SpineTool 2.0: A Deep Learning Platform with an Interactive User Interface for Dendritic Spine Segmentation and Morphological Analysis

    ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

    Key finding: Applied to in vitro primary hippocampal neurons from a low-dose amyloid-β model of Alzheimer’s disease, SpineTool 2.0 detected a larger and more complete population of dendritic spines than the original SpineTool and revealed statistically significant morphological changes under Aβ exposure that had previously gone undetected. +1 more finding

    Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →