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49/100

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Lewy body dementia

Topic: Brain proteins, microglia and lab models

Dementia is a defining feature of Lewy body disease: its timing and onset distinguish different clinical diagnoses, and its effect on quality of life is profound. However, it remains unclear whether processes leading to cognitive and motor symptoms in Lewy body disease differ. To clarify this, we use in-vivo neuroimaging to assess spatial gradients of inter-regional differences in structural and functional connectivity in 108 people across the Lewy body disease spectrum (46 Parkinson's with normal cognition (PD-NC), 62 Lewy body dementia (LBD)) and 23 controls. We show divergent structural gradient differences with cognitive impairment: PD-NC show increased inter-regional differentiation, whilst LBD show overall gradient distribution similar to controls despite widespread organisational differences at the regional level. We then assess cellular and molecular underpinnings of these organisational changes. We reveal similarities and also important differences in the drivers of cortical organisation between LBD and PD-NC, particularly in layer 4 excitatory neurons.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zarkali, A., Thomas, G. E. C., Hannaway, N., Dobreva, I., Grant‐Peters, M., Callaghan, M. F., et al. (2025). Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia. Nature Communications. https://doi.org/10.1038/s41467-025-66783-9

Vancouver

Zarkali A, Thomas GEC, Hannaway N, Dobreva I, Grant‐Peters M, Callaghan MF, et al. Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia. Nature Communications. 2025. doi:10.1038/s41467-025-66783-9. PMID: 41290734.

BibTeX

@article{zarkali2025-41290734,
  author  = {Zarkali, Angeliki and Thomas, George E. C. and Hannaway, Naomi and Dobreva, Ivelina and Grant‐Peters, Melissa and Callaghan, Martina F. and Ryten, Mina and Weil, Rimona Sharon},
  title   = {{Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-66783-9},
  pmid    = {41290734},
  url     = {https://doi.org/10.1038/s41467-025-66783-9}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

We show divergent structural gradient differences with cognitive impairment: PD-NC show increased inter-regional differentiation, whilst LBD show overall gradient distribution similar to controls despite widespread organisational differences at the regional level.

Why it matters

This in-vivo neuroimaging study found divergent structural connectivity patterns between Parkinson's disease with normal cognition and Lewy body dementia, with differences particularly in layer 4 excitatory neurons. It does not test any treatment or prevention, so its relevance to curing or preventing dementia is limited to understanding how these conditions differ.

Study details

Participants108
Evidence strengthLow

How this study scored 49/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Nature Communications)
Journal's citation record	4 / 4	Nature Communications: journal h-index 747 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	108 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 5 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 2.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Rimona Sharon Weil: h-index 39 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 5 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41290734)
Free to read	2 / 2	Free to read
Total	49 / 100	—

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