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Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment
Miao Lin, Qingze Zeng, Siyan Zhong, Shouping Nie, Ruiting Zhang, Hui Hong, Lingyun Liu, Shuyue Wang et al.. Neurology, 2025-11-24
Topic: Amyloid, tau and blood-test diagnosis
= 0.022). Our approach captured the complex morphological alterations of the ChP in AD. These findings provide valuable knowledge that AD pathologies may disrupt ChP structure, contributing to clinical progression. The pathologic substrates underlying these ChP morphological features remain to be elucidated, necessitating further investigation through imaging-histopathological comparison studies.
Key findings
- Our approach captured the complex morphological alterations of the ChP in AD.
- These findings provide valuable knowledge that AD pathologies may disrupt ChP structure, contributing to clinical progression.
- The pathologic substrates underlying these ChP morphological features remain to be elucidated, necessitating further investigation through imaging-histopathological comparison studies.
Why it matters
This study found that Alzheimer's disease pathologies may disrupt the structure of the choroid plexus, a brain structure, and that these changes relate to cognitive decline. However, the biological reasons behind these structural changes are still unknown and require further imaging and tissue studies.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 39 of the 96 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 8 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 5.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | Zhejiang University: institution h-index 1,040 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41284956) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 39 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 39 of the 96 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Lin, M., Zeng, Q., Zhong, S., Nie, S., Zhang, R., Hong, H., et al. (2025). Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment. Neurology. https://doi.org/10.1212/wnl.0000000000213953
Vancouver
Lin M, Zeng Q, Zhong S, Nie S, Zhang R, Hong H, et al. Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment. Neurology. 2025. doi:10.1212/wnl.0000000000213953. PMID: 41284956.
BibTeX
@article{lin2025-41284956,
author = {Lin, Miao and Zeng, Qingze and Zhong, Siyan and Nie, Shouping and Zhang, Ruiting and Hong, Hui and Liu, Lingyun and Wang, Shuyue and others},
title = {{Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment}},
journal = {Neurology},
year = {2025},
doi = {10.1212/wnl.0000000000213953},
pmid = {41284956},
url = {https://doi.org/10.1212/wnl.0000000000213953}
}
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Referenced by this study and also in the alzhub library, so you can read them here.
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