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Clinical and neuropsychological features associated with progression in subjective cognitive decline
Rafael Angel Villino‐Rodríguez, Mirla M. Ríos‐Rivera, Genoveva Montoya‐Murillo, Jonathan Patricio Baldera, Salomón Salazar‐Londoño, María Rodríguez‐Oroz, Miguel Germán Borda, Adolfo Jiménez‐Huete et al.. Frontiers in Aging Neuroscience, 2025-11-26
Topic: Risk, prevention and care in population studies
At baseline, SCDp were older, had a higher prevalence of hypertension and hypercholesterolemia and had worst performance on tests related to processing speed, verbal fluency, visual memory, verbal memory, and executive functioning. Factors associated with progression at follow-up were lower scores in some cognitive tests: MMSE, TMT-B, and the CERAD regarding trial 1 of immediate recall, trial 2 of immediate recall, trial 3 of immediate recall and the delay recall score. Lower scores on global cognition, executive functioning and verbal memory tests were predictors of progression to MCI or dementia in patients with SCD. These findings underscore the importance of nuances in neuropsychological evaluation, even with a normal score, for detecting high-risk individuals for early intervention.
Key findings
- At baseline, SCDp were older, had a higher prevalence of hypertension and hypercholesterolemia and had worst performance on tests related to processing speed, verbal fluency, visual memory, verbal memory, and executive functioning.
- Factors associated with progression at follow-up were lower scores in some cognitive tests: MMSE, TMT-B, and the CERAD regarding trial 1 of immediate recall, trial 2 of immediate recall, trial 3 of immediate recall and the delay recall score.
- Lower scores on global cognition, executive functioning and verbal memory tests were predictors of progression to MCI or dementia in patients with SCD.
- These findings underscore the importance of nuances in neuropsychological evaluation, even with a normal score, for detecting high-risk individuals for early intervention.
Why it matters
In people with subjective cognitive decline, lower scores on tests of global cognition, executive functioning and verbal memory predicted progression to mild cognitive impairment or dementia. This suggests that detailed neuropsychological testing, even when scores look normal, may help identify high-risk individuals for early intervention.
Study details
- Participants450
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Aging Neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Aging Neuroscience: journal h-index 174 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 450 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Mario Riverol: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Clinica Universidad de Navarra: institution h-index 435 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41383817) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fnagi.2025.1680762
- PubMed: 41383817
- Original source →
- Free full text: Frontiers in Aging Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Villino‐Rodríguez, R. A., Ríos‐Rivera, M. M., Montoya‐Murillo, G., Baldera, J. P., Salazar‐Londoño, S., Rodríguez‐Oroz, M., et al. (2025). Clinical and neuropsychological features associated with progression in subjective cognitive decline. Frontiers in Aging Neuroscience. https://doi.org/10.3389/fnagi.2025.1680762
Vancouver
Villino‐Rodríguez RA, Ríos‐Rivera MM, Montoya‐Murillo G, Baldera JP, Salazar‐Londoño S, Rodríguez‐Oroz M, et al. Clinical and neuropsychological features associated with progression in subjective cognitive decline. Frontiers in Aging Neuroscience. 2025. doi:10.3389/fnagi.2025.1680762. PMID: 41383817.
BibTeX
@article{villinorodriguez2025-41383817,
author = {Villino‐Rodríguez, Rafael Angel and Ríos‐Rivera, Mirla M. and Montoya‐Murillo, Genoveva and Baldera, Jonathan Patricio and Salazar‐Londoño, Salomón and Rodríguez‐Oroz, María and Borda, Miguel Germán and Jiménez‐Huete, Adolfo and others},
title = {{Clinical and neuropsychological features associated with progression in subjective cognitive decline}},
journal = {Frontiers in Aging Neuroscience},
year = {2025},
doi = {10.3389/fnagi.2025.1680762},
pmid = {41383817},
url = {https://doi.org/10.3389/fnagi.2025.1680762}
}
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