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A case report of late-onset schizophrenia differentiated from a dementing disorder
Shimada T, Uehara T, Nagasawa T, Hasegawa M, Maeda Y, Kawasaki Y.. Neurocase, 2021-12-23
Topic: Risk, prevention and care in population studies
We report a case of late-onset schizophrenia that required differentiation from a dementing disorder. The patient was an 83-year-old woman who had experienced auditory hallucinations since she was 67 years old. The patient had slightly elevated total tau and slightly decreased amyloid β1-42, cerebrospinal fluid biomarkers.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Shimada, T., Uehara, T., Nagasawa, T., Hasegawa, M., Maeda, Y., & Kawasaki, Y. (2021). A case report of late-onset schizophrenia differentiated from a dementing disorder. Neurocase. https://doi.org/10.1080/13554794.2021.2016858
Vancouver
Shimada T, Uehara T, Nagasawa T, Hasegawa M, Maeda Y, Kawasaki Y. A case report of late-onset schizophrenia differentiated from a dementing disorder. Neurocase. 2021. doi:10.1080/13554794.2021.2016858. PMID: 34949153.
BibTeX
@article{shimada2021-34949153,
author = {Shimada, T. and Uehara, T. and Nagasawa, T. and Hasegawa, M. and Maeda, Y. and Kawasaki, Y.},
title = {{A case report of late-onset schizophrenia differentiated from a dementing disorder}},
journal = {Neurocase},
year = {2021},
doi = {10.1080/13554794.2021.2016858},
pmid = {34949153},
url = {https://doi.org/10.1080/13554794.2021.2016858}
}
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Key findings
- The patient was an 83-year-old woman who had experienced auditory hallucinations since she was 67 years old.
- The patient had slightly elevated total tau and slightly decreased amyloid β1-42, cerebrospinal fluid biomarkers.
- This case was identified as late-onset schizophrenia.
- However, the results of cerebrospinal fluid biomarkers indicated that neurofibrillary tangles and neuronal death, which are characteristic of Alzheimer 's disease, may also have been present.
Why it matters
This case report describes an 83-year-old woman with late-onset schizophrenia whose CSF showed slightly elevated total tau and slightly decreased amyloid β1-42, suggesting Alzheimer's-type changes may also have been present. As a single case, it cannot show anything about treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 31/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurocase) |
| Journal's citation record | 1 / 4 | Neurocase: journal h-index 87 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 1 / 6 | Cited 0.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yasuhiro Kawasaki: h-index 44 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Kanazawa Medical University: institution h-index 232 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34949153) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 31 / 100 | — |
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