Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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In this update, we examine a checklist for real-world evidence use in Medicare drug price negotiations under the Inflation Reduction Act, a review of health technology assessment reassessments across major health technology assessment agencies, and two complementary studies that used natural experiment approaches to explore the relationship between herpes zoster vaccination and reduced dementia risk.
Why it matters
This update mentions two studies that used natural experiment approaches to explore a relationship between herpes zoster vaccination and reduced dementia risk. It does not report any treatment, cure, or prevention results itself.
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There are many reasons why people experiencing incarceration may be predisposed to developing dementia.
Why it matters
Both the ACE-III and M-ACE demonstrated utility for detecting suspected dementia in incarcerated males, with high negative predictive values. The M-ACE may be useful for screening out individuals who do not have dementia, while the ACE-III provides a comprehensive cognitive profile.
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How does place shape informal caregiving for and by ageing people with cognitive impairment in rural South Africa?
Why it matters
This ethnographic case study describes how a rural South African village supported a 59-year-old woman with dementia through community knowledge and informal networks, but her family could not get a government grant to pay a caregiver. It highlights how place and community ties shape informal dementia care in rural settings.
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Obstructive sleep apnoea (OSA) is increasingly recognised as a significant risk factor for cognitive decline and dementia.
Why it matters
This review reports that obstructive sleep apnoea is increasingly recognized as a risk factor for cognitive decline and dementia, and that positive airway pressure therapy shows promise for improving cognition particularly in people with mild cognitive impairment. It concludes that further research is needed to determine long-term cognitive benefits of treatment, especially in advanced dementia.
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This is the first reported case of AIWS in a patient with DLB.
Why it matters
This is a single case report of Alice in Wonderland syndrome in a patient with dementia with Lewy bodies, with a hypothesis about dysfunction in high-level visual networks. As a single case, it offers no treatment, cure or prevention.
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> 0.05). We observed distinct cognitive performances in subjects from both the DLB and AD groups across different stages of dementia.
Why it matters
This study confirms the high value of the MMSE and MoCA in distinguishing patients with dementia with Lewy bodies and Alzheimer's disease in the early stages of the disease. These tests can improve the differential diagnosis of these two dementia types.
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We found that COVID patients initially experienced substantially longer hospital stays (8.3 vs 4.6 days) and higher 30-day mortality (34% vs 5%) compared to patients without COVID.
Why it matters
This study examined hospital discharge outcomes among high-risk Medicare beneficiaries during the COVID-19 pandemic, finding that COVID patients initially had longer stays and higher mortality, with differences converging by mid-2022. It does not address treating, curing, or preventing Alzheimer's disease.
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Dietary intake moderated the association between several cSVD biomarkers and MoCA scores such that the expected negative association between cSVD biomarkers and cognition was seen at low levels of healthy dietary intake, but not at medium or high levels.
Why it matters
In older adults, healthy dietary intake moderated the link between cerebral small vessel disease biomarkers and cognitive scores, with the negative association seen only at low levels of healthy dietary intake. The authors suggest healthy diet may confer cognitive reserve against small vessel disease, but this is an observational finding and not proof that diet prevents dementia.
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Older people's immigration to a different country can place them in a vulnerable situation.
Why it matters
This qualitative study with professionals in Finland identified barriers to care and support for older immigrants and immigrants with dementia, including linguistic barriers, lack of digital skills, lack of information, loneliness, and cultural differences. It addresses access to care and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Commonalities emerged in barriers for accessing dementia training.
Why it matters
Rural and remote Australian health and aged care workers described barriers to dementia training, including staffing, time, and competing priorities, and enablers such as employer support and locally relevant training. This concerns workforce training and care delivery, not treating or preventing dementia.
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Factors like health concerns, environmental issues, and ethics have driven the rapid rise in veganism's popularity over the last decade.
Why it matters
This review is about nutritional deficiencies in vegan diets and strategies to prevent them, not about Alzheimer's disease. It provides no information relevant to treating, curing, or preventing Alzheimer's disease.
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In 2024, 90% of Medicare Advantage (MA) enrollees were in a plan that required prior authorization of home health care.
Why it matters
This interview study of 44 leaders found that prior authorization and utilization management of post-acute home health care were viewed as burdensome, with home health agency representatives reporting impacts on access to care and patients' experiences. It calls for additional research and policy attention so these techniques do not unintentionally cause patient harm.
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Hispanic older adults face significant barriers to healthcare access, stemming from multiple factors: limited income, high medical costs, elevated rates of chronic disease and dementia, and greater reliance on public insurance programs, relative to other racial, ethnic, and age groups.
Why it matters
This study found that older Mexican Americans living closer to the border reported worse health, more difficulty paying bills, lower independence, and increased risk of dementia diagnosis compared to those further from the border. It suggests a need for better policies for older Hispanic Americans with dementia in the border region.
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The ACPES scores were significantly higher for those who reported yes for pre-planning activities such as making a will, making a lasting power of attorney, telling one's doctor about end-of-life care preferences, and telling family or loved ones about end-of-life care preferences.
Why it matters
This study tested a survey that measures how ready people are to engage in advance care planning, and found it worked well in Singapore. It does not test any treatment, cure or prevention for Alzheimer's disease.
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Our studies showed that DC and DRs in VD and AD groups were significantly lower than those in controls, while AC values were significantly higher.
Why it matters
This study found that heart rate deceleration capacity, deceleration runs, acceleration capacity, and lipoprotein-related phospholipase A2 were associated with dementia and correlated with MMSE scores. Combining these indicators improved the sensitivity and specificity of dementia diagnosis.
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Falls are a leading cause of morbidity and mortality in older adults, especially among nursing home residents.
Why it matters
This paper describes an early-stage project to develop and test the feasibility of a robot with an infrared camera and machine learning software to detect falls and fall risk in nursing homes. It is about fall detection technology, not about treating, curing or preventing Alzheimer's disease.
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This study (RCT) investigated the impact of Expressive Therapies Continuum (ETC)-based art therapy on cognitive function and quality of life among older adults with dementia living in a complex care setting.
Why it matters
In this randomized trial, older adults with dementia who received 10 sessions of art therapy based on the Expressive Therapies Continuum showed increases in quality-of-life scores and in the language part of the MMSE, while the control group's language scores decreased. The authors describe these as exploratory preliminary findings that need larger samples, and the study concerns quality of life and cognition, not curing or preventing Alzheimer's disease.
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Lower birth rate is an independent risk factor for dementia, particularly in developed countries.
Why it matters
This global analysis found a significant inverse correlation between birth rate and dementia incidence, with lower birth rate identified as an independent risk factor for dementia, particularly in developed countries. It highlights the importance of considering birth rate in dementia studies.
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A total of eight studies were included from 1,384 search results, reviewing data from 10,449 cognitively unimpaired older adults.
Why it matters
This review found that loneliness or social isolation during the COVID-19 pandemic was linked to subjective cognitive decline in older adults, but only one study linked it to lower objective cognitive performance. It highlights the need for better tools and consideration of factors like depression, and does not show that reducing loneliness prevents dementia.
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The observation group had significantly lower Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores than the control group (both P<0.001).
Why it matters
In this study, comprehensive nursing interventions were followed by lower anxiety and depression scores, better treatment adherence, higher cognitive scores and better quality of life in dementia patients. The findings support nursing care for well-being and adherence, but they do not show an effect on the underlying disease.
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Five themes emerged. Both older adults and adult children had partial knowledge of dementia and were able to list learning new things and social activities as cognitively stimulating activities.
Why it matters
This qualitative study gathered perspectives from older Chinese Americans and their adult children on mobile-based cognitive training, finding strong interest but also concerns about transportation, language, eyestrain and dementia-related stigma. It provides information for developing culturally relevant cognitive training but does not test whether such training affects Alzheimer's disease.
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35/100
[Purpose] We evaluated the effects of a multicomponent intervention for pre-frail and frail older adults and assessed changes in cognitive function and body composition to explore frailty reversibility. [Participants and Methods] A total of 51 community-dwelling older adults aged 70 years or older were classified into the Robust (n=28) and Prefrail/Frail groups (n=23) using the Kihon Checklist.
Why it matters
This study found that a 3-month exercise and cognitive training intervention improved processing speed in pre-frail and frail older adults, with no significant changes in other cognitive measures. It suggests possible benefit for a specific cognitive function, but it does not show that the intervention treats, cures or prevents Alzheimer's disease.
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Of 142 respondents, 53% supported, 10% were uncertain, and 37% opposed legalizing euthanasia for terminal illness with severe symptoms.
Why it matters
This mixed methods study of Australian palliative care clinicians found support for legalizing voluntary assisted dying was lower for patients with severe dementia (5%) than for terminal illness with severe symptoms overall. It identified variables associated with clinicians' views and challenges of implementation.
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The identified deficits in the medical care of the target population and the approaches to solving them will be incorporated into the development of health policy recommendations in order to optimize the care situation of those affected in the long term.
Why it matters
Interviews with providers and caregivers identified major gaps in diagnosing and treating dementia in people with Down syndrome, including lack of knowledge, lack of suitable diagnostic tools, and doubts about the efficacy of antidementia medications. Suggested solutions included closer observation of behavior, caregiver involvement, and reducing polypharmacy, but no treatment was tested.
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's < 0.05). The findings suggest that neighborhood-level social deprivation might influence memory and motor status, primarily through its impact on motor brain health.
Why it matters
This pilot study suggests that neighborhood-level social deprivation might influence memory and motor status, mainly through its effect on motor brain health. It is a small pilot study and does not test any treatment, cure or prevention for Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Brain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction
- Frontotemporal dementia: patient characteristics, cognition, and behaviour
- Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
- Differential Associations of Lipid Profiles with Dementia and Cardiovascular Disease: Findings from the UK Biobank Cohort
- Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review
- Pharmacological treatment of Parkinson disease: a review
- A facilitated approach to family case conferencing for people with advanced dementia living in nursing homes: perceptions of palliative care planning coordinators and other health professionals in the IDEAL study
- Caring for Aged Dementia Care Resident Study (CADRES) of person-centred care, dementia-care mapping, and usual care in dementia: a cluster-randomised trial
- Association between low gait speed and cognition decline in older nursing home residents
- The GPCOG: a new screening test for dementia designed for general practice