Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Our study highlights the potential of Decipher‐AI for screening undiagnosed cognitive impairment in primary care.
Why it matters
This study evaluated an AI algorithm for detecting undiagnosed cognitive impairment in electronic health records and checked its performance across sociodemographic groups. It concerns detection, not treating, curing, or preventing Alzheimer's disease.
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ADI was positively associated with blood pressure and cardiometabolic index (CMI), and negatively associated with global and Preclinical Alzheimer's Cognitive Composite (PACC5) scores, in cognitively unimpaired (CU) individuals.
Why it matters
In cognitively unimpaired individuals, greater neighborhood disadvantage was associated with higher blood pressure and cardiometabolic index and lower global and Preclinical Alzheimer's Cognitive Composite scores. In those with mild cognitive impairment, neighborhood disadvantage was only associated with hemoglobin A1c.
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Summary statistics were obtained for sociodemographic and chronic diseases by using cross-tabulation analysis and comparing the county respondents with proportion tests.
Why it matters
In rural West Texas, factors including age 60-69, anxiety, depression, diabetes, hypertension, and cardiovascular disease were linked to cognitive impairment, with some differences between counties and between men and women. These are associations only, so the study cannot show that managing these conditions would prevent cognitive impairment.
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34/100
This may be due to caregiving challenges associated with the behavioral symptoms PWD exhibit and their reduced capacities to perform daily tasks.
Why it matters
This study found that access to more parks, healthy food outlets, social amenities, and social services was linked to lower risk of nursing home transition among people with dementia. It suggests neighborhood amenities may help people stay in the community, but it does not test a treatment or cure for Alzheimer's disease.
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Taken together, findings weave a relatively cohesive narrative: recovery from TBI is inextricably connected to social forces, and such forces warrant increased attention in TBI care and research.
Why it matters
This paper discusses social determinants of health and traumatic brain injury, finding that recovery from TBI is connected to social forces that warrant increased attention in TBI care and research. It also reports that risk for death by suicide, drug overdose and opioid overdose was substantially higher among military members who self-identified as 'other'.
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As demand for shoulder arthroplasty grows, adequate cost containment is of importance.
Why it matters
This study found that among Medicare patients having shoulder replacement surgery, having dementia was associated with significantly higher 90-day costs. It is about surgical costs and reimbursement, not about treating, curing, or preventing Alzheimer's disease.
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COVID-19 pandemic and subsequent lockdowns created a global public health crisis generating mental health problems including social isolation, stress, and anxiety especially for persons with dementia and their carers.
Why it matters
This small pilot found that people with mild to moderate cognitive impairment could interact socially in a virtual psychodrama group on Zoom. It suggests a way to reduce social isolation, but it did not test any effect on treating, curing, or preventing Alzheimer's disease.
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The current study aimed to provide data on the effectiveness of the 10 cm2 rivastigmine patch in patients with Alzheimer's disease (AD) in a real-world setting in Taiwan.
Why it matters
In this 48-week real-world study, the 10 cm2 rivastigmine patch showed numerical cognitive improvement at Week 24 but CASI and MMSE scores declined by Week 48, and the change in CDR score was not significant. It reports on an existing symptomatic drug in a single-arm, open-label study, not a cure or prevention.
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Direct survey-weighted rates were correlated with model-predicted rates in 43 counties (Pearson r = 0.32).
Why it matters
This modeling study estimated that subjective cognitive decline among US veterans rose from 13.83% in 2011 to 29.13% in 2019, with variation across counties. The authors suggest VA hospitals plan for cognitive assessments and referrals, especially in rural areas.
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DLB patients had higher medication and psychosis‐related costs than DRP patients who had other dementias.
Why it matters
This study compared healthcare costs between patients with dementia with Lewy bodies and other dementias who had psychosis, finding that DLB patients had a significant increase in total all-cause healthcare costs. It addresses costs of care, not treating, curing, or preventing Alzheimer's disease.
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In 2030 it is expected that approx. 2.170.000 PwD above age 65 are living in Germany.
Why it matters
This study estimated that about 2.17 million people over age 65 in Germany will have dementia in 2030, with the change varying widely between counties. It does not test any treatment, cure or prevention, but provides regional forecasts intended to help plan health care and support.
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Day care has a place in the menu of service for people with dementia living in the community.
Why it matters
This mapping study found significant variation across Ireland in the capacity of day care centres to cater for people with dementia, with the number of places per 100 persons with dementia varying from 9 to 16, and 20% of people with dementia not living within a 15km radius of a suitable day care centre. The study is about geographic accessibility and capacity of day care services, not about treating, curing, or preventing Alzheimer's disease.
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In 2017, the United Nations reported that the world's population aged 60 years and over was 962 million people, over twice as many older persons than was reported in 1980.
Why it matters
This review concerns interventions to improve prescribing for older people in care homes, where polypharmacy and inappropriate prescribing are common. It does not report results on treating, curing or preventing Alzheimer's disease itself.
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Taken together, they move us a little closer toward our goals of achieving health equity.
Why it matters
This collection of papers describes disparities in care and ways to measure them, including a measure of neighborhood disadvantage that may help target interventions. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Clinical and population-based epidemiological studies report variation in the observed prevalence and incidence of dementia with Lewy bodies (DLB).
Why it matters
This study found that the proportion of dementia cases diagnosed as dementia with Lewy bodies varied significantly between memory clinics and regions. It does not test any treatment, cure or prevention, and the authors note it is unclear whether this variation reflects true differences or differences in diagnosis.
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34/100
Shared decision-making is defined as a process where healthcare professionals and patients make decisions together, using the best available evidence.
Why it matters
This is a research protocol for a feasibility trial of shared decision-making on life-and-care plans in long-term care facilities for residents with dementia. It does not yet report results on treating, curing, or preventing Alzheimer's disease.
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The prevalence of dementia was estimated at 44.4 million people worldwide in 2013, and in the absence of any significant new scientific discovery, prevalence rates are estimated to increase to 75.6 million in 2030 and 135.5 million in 2050.1 Alzheimer’s disease is the most common irreversible form of dementia.
Why it matters
This article reports projected increases in dementia prevalence worldwide and notes that Alzheimer's disease is the most common irreversible form of dementia. It provides no findings on treating, curing, or preventing Alzheimer's disease.
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The adaption of the battery for French-speaking subjects is reported as well as preliminary results of the on-going validation study of the GRECOG-VASC group [Clinical Trial NCT01339195].
Why it matters
This paper reviews neuropsychological testing standards for vascular cognitive impairment and notes that about a third of some vascular dementia patients have amyloid PET suggestive of Alzheimer's disease. It is a review of assessment and diagnosis, not a study of treating, curing, or preventing Alzheimer's disease.
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On supplementary questioning, he revealed multiple recent social stressors, including the 1-year anniversary of his partner's death and an impending eviction from his home with the loss of his beloved garden.
Why it matters
This case report describes an older individual with suicidal ideation in the emergency department and discusses challenges in suicide prevention for older adults. It does not address treating, curing, or preventing Alzheimer's disease.
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In theory, semantic memory may trigger and support the execution of everyday activities.
Why it matters
Three patients with semantic dementia were compared with 40 normal controls on everyday activities performed in their homes; two patients had significant difficulties needing assistance with all operations of problem-solving, while one showed no difficulties despite severe semantic deficits. The results suggest semantic deficits alone cannot explain the difficulties observed but may contribute to some aspects of everyday actions.
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Of 1,212,015 beneficiaries, 11.9 per 1,000 had prevalent and 2.9 new cases of epilepsy.
Why it matters
This study found that epilepsy prevalence varied geographically among older Americans, with nine of eleven Stroke Belt states among the twenty states with the highest prevalence, and that this variation was not explained by known risk factors. It does not test a dementia treatment or prevention, so it cannot show how to cure or prevent dementia.
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Prevalence estimates for traditional CVD risk factors were: hypertension, 25%; diabetes, 8%; hypercholesterolaemia, 12%; obesity, 25%; smoking 15%.
Why it matters
This survey reports the burden of cardiovascular disease risk factors in Jamaica, such as hypertension, diabetes, hypercholesterolaemia, obesity and smoking, and it does not address Alzheimer's disease. It contains no findings about dementia treatment, cure or prevention.
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CD28 molecule expression on the surface of T cells plays a critical role in upregulation of various cytokines synthesis and T-helper (Th) cell proliferation and differentiation.
Why it matters
This small study in 48 elderly people found that six months of moderate exercise training increased certain T-helper cell numbers and shifted the immune balance. It measured immune markers only and did not assess memory, dementia, or any Alzheimer's outcome.
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The present authors provide preliminary evidence for the validity and reliability of the CAS-ID.
Why it matters
This pilot study developed and tested a caregiver activity survey for use with people who have Down syndrome and dementia. It is a measurement tool for care planning, not a treatment, cure or prevention for Alzheimer's disease.
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Age-related declines in language and other neuropsychological variables were examined in 60 adults with Down syndrome.
Why it matters
In 60 adults with Down syndrome, aging was significantly related to language comprehension and self-help skills, but verbal skills were not significantly related to aging. The authors note that declines are often interpreted as Alzheimer disease symptoms but are not well understood and may have other explanations.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The accuracy of Medicare claims as an epidemiological tool: the case of dementia revisited
- Effects of age on tissues and regions of the cerebrum and cerebellum
- Brief screening tests for dementia
- Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia
- Sensor-derived physical activity parameters can predict future falls in people with dementia
- Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016
- Detection of emergency department patients at risk of dementia through artificial intelligence
- Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment
- Reduction of concurrent use of highly anticholinergic medications in an integrated healthcare system: 2018–2021
- Terminal care for persons with advanced dementia in the nursing home and home care settings