Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Stroke is the leading cause of acquired disability.
Why it matters
This review discusses how secondary neurodegeneration after stroke may contribute to post-stroke cognitive impairment and dementia, noting that understanding of how stroke leads to these conditions remains incomplete. It is a discussion of mechanisms, not a treatment or prevention finding.
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Participation in late-life cognitive activities has been associated with a slower rate of cognitive decline and reduced risk of dementia; however, whether this association is independent of earlier experiences is unclear.
Why it matters
This study examined whether cognitive activity during early life, midlife and late life is associated with the risk of Alzheimer disease dementia, noting that whether the late-life association is independent of earlier experiences is unclear. The provided text gives no results, so no treatment, cure or prevention conclusion can be drawn.
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People use advance directives to express preferences that direct their future care when they lack decision-making capacity.
Why it matters
This article describes a new dementia advance directive designed to let people document a wish to stop eating and drinking by hand if they reach advanced dementia, addressing gaps in earlier directives. It is a discussion of documentation and ethics, not a study of a treatment, cure or prevention for Alzheimer's disease.
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This review explores the complex relationship between neuroinflammation and cognitive decline in individuals with Type 2 Diabetes (T2D).
Why it matters
This review describes how chronic neuroinflammation linked to type 2 diabetes may contribute to cognitive impairment and dementia, with microglial activation seen in brain regions important for cognition. It does not report a treatment that prevents or reverses this decline.
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Enrollment in an MA plan is associated with a higher probability of AWV uptake, particularly among vulnerable populations from racial and ethnic minorities, dual eligibility, and those diagnosed with ADRD.
Why it matters
This study found that Medicare Advantage enrollees were 4.4 percentage points more likely to receive an Annual Wellness Visit than traditional Medicare enrollees, including among those diagnosed with Alzheimer's disease and related dementias. It contains no findings on treating, curing, or preventing Alzheimer's disease itself.
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32/100
SSP is a flexible and predictive neighborhood‐level measure of health disparities compared to indices like the Gini coefficient.
Why it matters
This study found that Medicare beneficiaries living in more deprived or racially segregated neighborhoods had higher dementia prevalence, independent of individual characteristics. It does not test a treatment or cure, but it suggests that reducing neighborhood deprivation could be explored as a way to lower dementia prevalence.
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Among Medicare beneficiaries from 2008 to 2018, AD prevalence was generally stable, while MCI increased.
Why it matters
This study estimated the prevalence of Alzheimer's disease and mild cognitive impairment among Medicare beneficiaries, finding that about 1.2 million Alzheimer's disease patients and 490,000 mild cognitive impairment patients were identified in 2018. Women, older age, White race, and Northeast region were associated with higher prevalence of Alzheimer's disease and mild cognitive impairment in 2018.
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32/100
These findings suggest that caregivers living in rural regions may depend more on informal support for meeting basic care needs of their relative living with dementia.
Why it matters
Among dementia family caregivers in rural Appalachia, those with higher income and those caring for people with more daily-living limitations used more formal services. More help from family or friends was linked to less use of support services, suggesting caregivers in these regions may rely more on informal support.
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Understanding and addressing SDOH associated with hospitalizations among AI/AN older adults, with and without dementia, may aid in the development of strategies that reduce preventable hospitalization.
Why it matters
This study found that American Indian and Alaska Native adults aged 65 and older with dementia had higher odds of hospitalization than those without dementia. The findings concern hospital utilization and social determinants of health, not treatment, cure, or prevention.
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Thirty thousand three hundred and ninety-eight deaths attributable to dementia as the underlying or related cause (multiple causes) were reported during 2015-2019.
Why it matters
In Zhejiang Province, China, counties and districts with poorer economic status, insufficient health resources, and worse pollution had a higher risk of deaths due to dementia. The study is about socioeconomic and environmental factors associated with dementia mortality, not about treating, curing, or preventing Alzheimer's disease.
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Improved performance and increased self-reported daily use of the hearing aid were observed after the period of guidance and telemonitoring via the system for all research participants.
Why it matters
This study developed an internet-based system for guidance and telemonitoring of hearing aid users and found improved performance and increased daily use of hearing aids. It does not address treating, curing, or preventing Alzheimer's disease.
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In medical school, students learn to view the world through a biomedical lens.
Why it matters
This personal essay describes how the standard mental status exam can miss a person's individuality, illustrated through the author's grandmother who has Alzheimer's disease. It is a reflection on clinical practice and does not test any treatment, cure, or prevention.
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Dementias are expensive diseases: the net annual cost in European healthcare is about € 28.000 per case with a strong stage dependency, of which medical care accounts for about 19%.
Why it matters
This survey of German memory clinics calculated the personnel and procedure costs of diagnosing dementia, including biomarker tests, and found these costs are not fully reimbursed. It is about diagnostic costs, not about treating, curing, or preventing Alzheimer's disease.
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Many National Forest Inventory (NFI) stakeholders would benefit from accurate estimates at finer geographic scales than most currently implemented in operational estimates using NFI sample data.
Why it matters
This study used small area estimation to improve the precision of county-level forest volume estimates in three U.S. states. It provides no information on treating, curing or preventing Alzheimer's disease.
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Predictors of an AD dementia diagnosis included age (odds ratio [OR], 1.71) and use of antipsychotics (OR, 2.50) and hypertension medication (OR, 1.25).
Why it matters
This study found that older age, use of antipsychotics, and use of hypertension medication predicted an Alzheimer's disease dementia diagnosis, while use of anxiolytics, inpatient status at diagnosis, and a history of stroke were possible protective factors. None of these factors differentiated Alzheimer's disease dementia from all-cause dementia.
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32/100
She presented compelling data that showed the vastly improved ease of use and overall satisfaction of nasal glucagon vs its injectable counterpart.
Why it matters
This news piece reports on nasal versus injectable glucagon for severe low blood sugar and on associations between severe hypoglycemia and heart conditions. It contains no information on treating, curing, or preventing Alzheimer's disease.
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OpenStreetMap provides a valuable crowd-sourced database of raw geospatial data for constructing models of urban street networks for scientific analysis.
Why it matters
This project built and shared street network models and measures for locations across the United States. It provides no information on treating, curing or preventing Alzheimer's disease.
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120 patients were included in the audit with a confirmed stroke on CTB/MRI.
Why it matters
In this audit of 120 stroke patients, early cognitive screening helped predict discharge destination and length of stay, with more severe cognitive impairment linked to longer stays and lower likelihood of going home. The findings support using early cognitive screening to plan care after stroke.
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32/100
Care assistants have a unique insight into the lives of service users and those factors which may impede or enhance the delivery of high quality dementia oriented care.
Why it matters
This interview study examines care assistants' experiences of dementia care in British long-term care environments. It offers no information on treating, curing or preventing Alzheimer's disease.
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It is a well established fact that Down Syndrome (DS) individuals have a tendency to develop Alzheimer's disease (AD) (Lott, I.T., Head, E., 2005.
Why it matters
Young people with Down syndrome but without significant Alzheimer's clinical symptoms showed reduced sensitivity to optic flow motion compared with mental age-matched controls, and visual evoked potentials showed no response to optic flow. This is a study of visual motion perception in young adults with Down syndrome, not a test of any treatment, cure, or prevention of Alzheimer's disease.
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fifty-five geriatricians responded. Ninety-one per cent were consultant physicians, and 71% were not involved in outpatient diagnostic services.
Why it matters
In this survey of 55 consultant geriatricians in the UK, most felt that current dementia training was inadequate and wanted more structure, more time on attachments, less geographical variation, and better collaboration with psychiatry. This is about doctor training and confidence in dementia care, not about treating, curing, or preventing the disease.
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In the history of psychiatry, the words mad and psychosis have often been used interchangeably, negatively contributing to the stigma associated with the term and the illness itself.
Why it matters
This paper reviews psychosis in children and youth with a focus on early-onset schizophrenia, noting that very early onset schizophrenia is associated with greater familial vulnerability and a worse prognosis. It also notes that many of these children are mistakenly identified as having a pervasive developmental disorder because of similarities in presentation.
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From 1999 to 2004, the U.S. age-adjusted annual death rate per 100,000 for dementia was 628 in blacks and 647 in whites.
Why it matters
From 1999 to 2004, overall dementia death rates were similar in US Blacks and Whites, but the racial difference varied by region. Blacks were relatively more likely to receive a diagnosis of unspecified dementia or senility than Alzheimer's disease.
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The object of this study was to investigate the attitudes of physicians, nurses and the general public to physician-assisted suicide (PAS), active voluntary euthanasia (AVE) and passive euthanasia (PE) in Finland.
Why it matters
In Finland, passive euthanasia was most often considered acceptable in a scenario of severe dementia, by 88% of physicians, 79% of nurses, and 64% of the general public. This concerns end-of-life attitudes, not the treatment, cure, or prevention of Alzheimer's disease.
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This review discusses the research published in the last five years on the behavioral, genetic, medical, and neuroscience aspects of Down syndrome.
Why it matters
This is a review of research published over five years on the behavioral, genetic, medical, and neuroscience aspects of Down syndrome, with Alzheimer disease among the most active areas. It reports on existing research and does not present a new treatment, cure, or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial
- Postoperative delirium in elderly patients is associated with subsequent cognitive impairment
- A Shelter of Others by Charles Dodd White (review)
- Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis
- Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial
- Meta-Analysis of the Effects of Computerized Cognitive Training on Executive Functions: a Cross-Disciplinary Taxonomy for Classifying Outcome Cognitive Factors
- Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study
- Promotors and barriers to the implementation and adoption of assistive technology and telecare for people with dementia and their caregivers: a systematic review of the literature
- Intervention for the Management of Neuropsychiatric Symptoms to Reduce Caregiver Stress: Protocol for the Mindful and Self-Compassion Care Intervention for Caregivers of Persons Living With Dementia
- Automatic dementia screening and scoring by applying deep learning on clock-drawing tests