This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

35/100

✓ Peer-reviewed alzhub usefulness score 35 out of 100. Health systems and care delivery

Topic: Risk, prevention and care in population studies

Plain-language summary

In this update, we examine a checklist for real-world evidence use in Medicare drug price negotiations under the Inflation Reduction Act, a review of health technology assessment reassessments across major health technology assessment agencies, and two complementary studies that used natural experiment approaches to explore the relationship between herpes zoster vaccination and reduced dementia risk.

What this study adds

Evidence grade: Low

This update mentions two studies that used natural experiment approaches to explore a relationship between herpes zoster vaccination and reduced dementia risk. It does not report any treatment, cure, or prevention results itself.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Paul, A., & Ramagopalan Sreeram, V. (2025). R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 19. Journal of comparative effectiveness research. https://doi.org/10.57264/cer-2025-0063

Vancouver

Paul A, Ramagopalan Sreeram V. R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 19. Journal of comparative effectiveness research. 2025. doi:10.57264/cer-2025-0063. PMID: 40350777.

BibTeX

@article{paul2025-40350777,
  author  = {Paul, Arora and Ramagopalan Sreeram, V.},
  title   = {{R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 19}},
  journal = {Journal of comparative effectiveness research},
  year    = {2025},
  doi     = {10.57264/cer-2025-0063},
  pmid    = {40350777},
  url     = {https://doi.org/10.57264/cer-2025-0063}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

In this update, we examine a checklist for real-world evidence use in Medicare drug price negotiations under the Inflation Reduction Act, a review of health technology assessment reassessments across major health technology assessment agencies, and two complementary studies that used natural experiment approaches to explore the relationship between herpes zoster vaccination and reduced dementia risk.

Why it matters

Study details

Evidence strengthLow

How this study scored 35/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of comparative effectiveness research)
Journal's citation record	0 / 4	Journal of Comparative Effectiveness Research: journal h-index 50 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 4 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.3 citations a year over 3 year(s) since 2025
Impact for its field and year	3 / 6	Cited 3.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Sreeram V Ramagopalan: h-index 10 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Toronto: institution h-index 1,923 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40350777)
Free to read	0 / 2	Behind a paywall — scores zero
Total	35 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here.

Later studies that cite this one

1 study in the alzhub library lists this one in its references.

Related studies in Health systems and care delivery from nearby years

Also in Health systems and care delivery

172 studies in the library are filed under Health systems and care delivery with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Health systems and care delivery hub.

Similar studies

More on Health systems and care delivery

See all studies in Health systems and care delivery →