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Birth Rate as a Determinant of Dementia Incidence: A Comprehensive Global Analysis
Wenpeng You. American Journal of Alzheimer s Disease & Other Dementias®, 2025-01-01
Topic: Risk, prevention and care in population studies
Background The role of parity in predicting dementia risk in women is debated. This study examines how birth rate affects global dementia incidence. Methods Country-specific data on birth rate and dementia incidence rate were analyzed using bivariate analysis, partial correlation, and multiple linear regression. Confounding factors such as aging, affluence, genetic predisposition (I bs ), and urbanization were considered. Results Pearson’s r and nonparametric analyzes showed a significant inverse correlation between birth rate and dementia incidence. This relationship remained significant after controlling for aging, affluence, I bs , and urbanization. Multiple linear regression identified birth rate as a significant predictor of dementia incidence, and as the strongest predictor. Affluence and urbanization were not significant predictors. The correlation was stronger in developing countries. Conclusions Lower birth rate is an independent risk factor for dementia, particularly in developed countries. These findings highlight the importance of considering birth rate in dementia studies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
You, W. (2025). Birth Rate as a Determinant of Dementia Incidence: A Comprehensive Global Analysis. American Journal of Alzheimer s Disease & Other Dementias®. https://doi.org/10.1177/15333175241287677
Vancouver
You W. Birth Rate as a Determinant of Dementia Incidence: A Comprehensive Global Analysis. American Journal of Alzheimer s Disease & Other Dementias®. 2025. doi:10.1177/15333175241287677. PMID: 39878193.
BibTeX
@article{you2025-39878193,
author = {You, Wenpeng},
title = {{Birth Rate as a Determinant of Dementia Incidence: A Comprehensive Global Analysis}},
journal = {American Journal of Alzheimer s Disease \& Other Dementias®},
year = {2025},
doi = {10.1177/15333175241287677},
pmid = {39878193},
url = {https://doi.org/10.1177/15333175241287677}
}
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Key findings
- Results Pearson’s r and nonparametric analyzes showed a significant inverse correlation between birth rate and dementia incidence.
- This relationship remained significant after controlling for aging, affluence, I bs , and urbanization.
- Multiple linear regression identified birth rate as a significant predictor of dementia incidence, and as the strongest predictor.
- Affluence and urbanization were not significant predictors.
- These findings highlight the importance of considering birth rate in dementia studies.
Why it matters
This global analysis found a significant inverse correlation between birth rate and dementia incidence, with lower birth rate identified as an independent risk factor for dementia, particularly in developed countries. It highlights the importance of considering birth rate in dementia studies.
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Study details
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American Journal of Alzheimer s Disease & Other Dementias®) |
| Journal's citation record | 1 / 4 | American Journal of Alzheimer s Disease & Other Dementias®: journal h-index 93 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 4 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Wenpeng You: h-index 16 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Adelaide: institution h-index 918 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39878193) |
| Free to read | 2 / 2 | Free to read |
| Total | 35 / 100 | — |
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Read the original
- DOI: 10.1177/15333175241287677
- PubMed: 39878193
- Original source →
- Free full text: American Journal of Alzheimer s Disease & Other Dementias® →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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