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Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction
Alexis Demas. Frontiers in Neurology, 2025-03-27
Topic: Risk, prevention and care in population studies
This is the first reported case of AIWS in a patient with DLB. We hypothesize that selective dysfunction of high-level visual networks-particularly in the right extrastriate cortex responsible for the canonical storage of object size-may lead to an agnosia of object size. This case underscores the importance of considering AIWS within the spectrum of visual disturbances in DLB. Theoretical These findings provide novel insights into the neurobiology of visual cognition, aligning with Husserl's concept of the "primordial body" (Urleib) and intuition. They suggest that disruptions in the integration of visual sensory inputs and canonical object properties may critically influence the conscious reconstruction of reality.
Key findings
- This is the first reported case of AIWS in a patient with DLB.
- We hypothesize that selective dysfunction of high-level visual networks-particularly in the right extrastriate cortex responsible for the canonical storage of object size-may lead to an agnosia of object size.
- This case underscores the importance of considering AIWS within the spectrum of visual disturbances in DLB.
- Theoretical These findings provide novel insights into the neurobiology of visual cognition, aligning with Husserl's concept of the "primordial body" (Urleib) and intuition.
- They suggest that disruptions in the integration of visual sensory inputs and canonical object properties may critically influence the conscious reconstruction of reality.
Why it matters
This is a single case report of Alice in Wonderland syndrome in a patient with dementia with Lewy bodies, with a hypothesis about dysfunction in high-level visual networks. As a single case, it offers no treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 35/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in Neurology) |
| Journal's citation record | 2 / 4 | Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Alexis Demas: h-index 6 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Groupe Hospitalier du Havre: institution h-index 89 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40212614) |
| Free to read | 2 / 2 | Free to read |
| Total | 35 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fneur.2025.1556218
- PubMed: 40212614
- Original source →
- Free full text: Frontiers in Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Demas, A. (2025). Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction. Frontiers in Neurology. https://doi.org/10.3389/fneur.2025.1556218
Vancouver
Demas A. Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction. Frontiers in Neurology. 2025. doi:10.3389/fneur.2025.1556218. PMID: 40212614.
BibTeX
@article{demas2025-40212614,
author = {Demas, Alexis},
title = {{Alice in Wonderland Syndrome in dementia with Lewy bodies: a case report exploring visual cognition dysfunction}},
journal = {Frontiers in Neurology},
year = {2025},
doi = {10.3389/fneur.2025.1556218},
pmid = {40212614},
url = {https://doi.org/10.3389/fneur.2025.1556218}
}
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