Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Participant experiences and perceptions formed three themes: (1) aging accelerates PCDS progression, (2) PCDS threatening daily life, and (3) adapting to changes.
Why it matters
This qualitative study describes how middle-aged and older adults with physio-cognitive decline syndrome experience decline and adapt to it, and it does not test any treatment, cure or prevention. It suggests that coping strategies such as health maintenance, cognitive training, social participation and professional support may help people manage the condition, but it provides no evidence that these change the course of Alzheimer's disease.
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The two methods demonstrated a growing need for palliative care in the observed and projected period.
Why it matters
This analysis projects a growing need for palliative care in Australia, with people living with dementia among those expected to drive future need. It notes that current workforce trends are unlikely to meet this growing need.
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Individuals with dementia were more likely to have staff or family members present at death, to receive documented decisions to shift to EOL care, have symptom assessments made the final week of life and prescription of injectables.
Why it matters
This Swedish registry study found that people with dementia received higher quality end-of-life care in several domains than those without dementia, such as having staff or family present at death and documented decisions to shift to end-of-life care. However, they were less likely to express preferences for place of death or be informed about care transitions, highlighting the need for early, proactive care planning.
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Twenty-six participants (15 ED clinicians, 3 caregivers, 8 community advisors) contributed perspectives.
Why it matters
This co-design study gathered perspectives from clinicians, caregivers and community advisors on improving sleep for people with dementia boarding in the emergency department. Stakeholders suggested strategies such as reducing noise and light and involving caregivers, which may mitigate sleep disruption and delirium risk, but implementation feasibility and effects on patient outcomes have not yet been evaluated.
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36/100
The psychometric properties of the Neuropsychiatry Unit Cognitive Assessment short-form versions were comparable with the original, with all maintaining high convergent validity and reliability.
Why it matters
This study developed and validated a 10-item short form of the NUCOG cognitive assessment tool, which showed sensitivity of 0.98 and specificity of 0.95 for dementia with a cut-off score of 42/54. It is a shorter assessment tool and does not treat, cure or prevent Alzheimer's disease.
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36/100
China has the world's highest dementia prevalence, disproportionately impacting rural areas.
Why it matters
This qualitative study of 25 rural Chinese dementia caregivers identified limited dementia knowledge, multiple burdens, family conflict, coping strategies, and unmet support needs. It calls for culturally relevant policies and service infrastructure but did not test any intervention.
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One-third of hospitalizations were PPHs.
Why it matters
This study found that potentially preventable hospitalizations among Medicare beneficiaries with dementia were more common in highly disadvantaged areas, especially rural-or-micropolitan ones. It points to expanding access to ambulatory care in disadvantaged areas, but reports no treatment, cure or prevention of Alzheimer's disease.
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Foundation models (FMs) are entering Alzheimer's disease and related dementias (ADRD), yet bedside impact remains limited.
Why it matters
This perspective article argues for hybrid artificial intelligence that combines statistical learning with clinical knowledge and clinician oversight, proposing a three-level framework for dementia care. It is a roadmap for developing interpretable tools and does not report a treatment, cure, or prevention for Alzheimer's disease.
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Dementia is a neurodegenerative condition marked by progressive cognitive decline, which affects people worldwide.
Why it matters
This integrative review describes shared inflammatory pathways across different dementia types, with activated microglia and astrocytes releasing pro-inflammatory cytokines that can lead to synaptic dysfunction and neuronal degeneration. It is a review of mechanisms and potential therapeutic targets, not evidence of an existing treatment or cure.
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Residing in neighborhoods characterized by low-income, low-vehicle access, and higher low-fat milk prices was associated with a greater risk of incident dementia.
Why it matters
This study found that living in neighborhoods with low income, low vehicle access, and higher low-fat milk prices was linked to a greater risk of developing dementia. It points to food environment factors that may affect dementia risk, but it does not test a treatment or cure.
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The study sample was NHATS respondents who needed assistance with activities of daily living (ADL) or instrumental activities of daily living (IADL), and who did not live with a spouse (N = 512).
Why it matters
This study found that during COVID-19, people in areas with more shelter-in-place days were less likely to receive more help, with no significant differences by dementia status. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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The current study provides evidence that more nuanced, data‐driven approaches can reveal commonalities in the etiology and underlying neurobiology of individuals across traditional categories of CU, MCI, or AD.
Why it matters
Using brain imaging and cognitive data from 515 people, a clustering method identified four data-driven groups that cut across the standard labels of cognitively unimpaired, mild cognitive impairment and Alzheimer's disease. This is a methodological study about how people are categorized, not about treating or preventing dementia.
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Catatonia is a severe and potentially life-threatening but often reversible neuropsychiatric syndrome.
Why it matters
This review offers practical guidance for palliative care clinicians to recognize, assess, and manage catatonia in seriously ill patients, noting it can overlap with delirium, dementia, and end-of-life changes. It emphasizes bedside tools and treatments including benzodiazepines and electroconvulsive therapy.
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36/100
Of 343 palliative care evaluations (for 322 unique patients), 38% were of patients who identified as African American/Black, 38% as White, 9% as Asian/Pacific Islander, and 15% as other races; 41% were of patients who identified as Hispanic/Latino (measured separately from race); 80% were of female patients; and the mean patient age was 88 years.
Why it matters
Among 343 palliative care evaluations, dementia was the only factor significantly and negatively associated with being deemed eligible for palliative care, meaning patients with dementia were less likely to be referred. This concerns referral decisions and access to palliative care, not treatment, cure or prevention of the disease.
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The CatBoost-based risk model achieved an area under the receiver-operating characteristic curve (AUROC) of 0.814 (<70 years) and 0.892 (<65 years).
Why it matters
Machine learning models using health record data predicted risk and prognosis of early-onset dementia, with key predictors including age, employment status, and education. These are screening and prediction tools, not treatments, cures, or ways to prevent dementia.
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Three themes identified include (a) LOVOT's role in supporting engagement and stimulating conversation, (b) the irreplaceability of human touch and emotional nuances, and (c) concerns about ownership and equitable resource allocation.
Why it matters
People with dementia and family caregivers described a socially assistive robot as supporting engagement and conversation, but stressed that human touch and emotional nuance cannot be replaced. They also raised concerns about ownership and fair allocation of such resources, so this work informs how robots might be introduced ethically in long-term care rather than offering a treatment or cure.
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Type 2 diabetes (T2DM) significantly increases the risk of dementia due to overlapping metabolic, molecular, and genetic factors.
Why it matters
This review describes how type 2 diabetes increases dementia risk through overlapping metabolic, molecular, and genetic factors, and discusses potential therapies targeting insulin signaling, oxidative damage, and inflammation. It notes that clinical translation of these therapies remains challenging due to the complexity of diabetes-associated dementia.
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Four GPs and eleven physicians were interviewed, and four major themes emerged: (1) knowledge of best practices of BPSD management, (2) awareness of current challenges in BPSD management, (3) non-involvement, blame shifting and rationalisation: perceived reasons for the current challenges and (4) suggested solutions.
Why it matters
This interview study found that general practitioners and physicians knew that non-pharmacologic approaches should be first-line for behavioral and psychological symptoms of dementia, yet psychotropic over-prescription and inadequate implementation of these approaches persisted. It describes a gap between knowledge and practice and does not test any treatment, cure or prevention for Alzheimer's disease.
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Processed meats are a significant source of proteins, indispensable amino acids (IAA), A and B vitamins, zinc, phosphorus, iron, and several micronutrients (Table 1).
Why it matters
This paper describes the nutritional content of processed meats, including proteins, vitamins, and minerals. It provides no information on treating, curing, or preventing Alzheimer's disease.
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A higher GPF was associated with better cognitive function in institutionalized older adults with dementia.
Why it matters
In this cross-sectional study, older adults with dementia who were physically fitter also had better cognitive function. Because the study looked at one point in time, it cannot show whether improving fitness would slow cognitive decline, and the authors say longer and experimental studies are needed.
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Dementia poses an on-going Canadian challenge due to an aging population, with cases projected to rise significantly by 2050.
Why it matters
This exploratory, conceptual economic analysis found that a digital health intervention for people with mild cognitive impairment could be cost-effective for preventing dementia in Canada. The authors state the findings are based on modeled assumptions without empirical efficacy data, so they should be interpreted with caution until validated in real-world settings.
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Physical and cognitive decline significantly affects seniors’ quality of life.
Why it matters
This usability study of a drum-based game found improved game scores and high engagement over two weeks in older adults, including some with neurocognitive disorders. It supports only the feasibility and usability of the game, not any effect on treating, curing or preventing Alzheimer's disease.
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We used 1387 safety event reports for model development, 989 (71.3%) reports related to situational factors and 119 (8.6%) reports related to active failures.
Why it matters
A machine learning model analyzed 1387 safety event reports from hospitalised patients with dementia, performing well for situational factors (precision 0.843, recall 0.826) but poorly for active failures (precision 0.333, recall 0.056). It aims to inform safety interventions and does not treat, cure, or prevent Alzheimer's disease.
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American Indian governments located in a region west of the Cascade mountain range and the government of the state of Washington offer programs to serve the needs of a growing American Indian elder and disabled population through the services of individuals caring for family members and also individuals employed to provide care.
Why it matters
This describes how American Indian governments and the state of Washington provide caregiver and elder support programs for people with dementia. It is about caregiving policy and services, not about treating, curing or preventing Alzheimer's disease.
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The review included 45 studies and identified key components and processes for successfully implementing advance care planning in dementia care.
Why it matters
This review of 45 studies identified key components and processes for putting advance care planning into practice in dementia care. It does not test any treatment, cure or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Capturing the costs of end-of-life care: comparisons of multiple sclerosis, Parkinson's disease, and dementia
- Atrial fibrillation and cognitive decline: a longitudinal cohort study
- Nonfluent progressive aphasia and semantic dementia: a comparative neuropsychological study
- Documentation and evaluation of cognitive impairment in elderly primary care patients
- Multimorbidity in dementia: Current perspectives and future challenges
- Wrist actigraphy
- Association between palliative care and healthcare outcomes among adults with terminal non-cancer illness: population based matched cohort study
- Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens
- The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort
- Insight into cerebral microvessel endothelial regulation of cognitive impairment: A systematic review of the causes and consequences