Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Vascular dementia (VaD) ranks as the second most prevalent subtype of dementia, surpassed only by Alzheimer's disease (AD).
Why it matters
This review examines how cerebrovascular endothelial cells and related cells contribute to vascular dementia and discusses possible therapeutic targets. It is a review of mechanisms, not evidence that any treatment cures or prevents dementia.
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1508 articles were retrieved and screened using pre-established inclusion criteria; 21 empirical articles were retained.
Why it matters
This scoping review of 21 empirical articles found that reminiscence in arts-based interventions for dementia care was linked to themes of social connection, bridging past and present, and increased enjoyment and confidence. The benefits of reminiscence were unanimously observed across diverse studies, and the authors call for future research.
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acceptability, appropriateness, and feasibility.
Why it matters
This study found that a Medicare cognitive assessment and care plan service was acceptable and appropriate to primary care providers and staff, though feasibility was unclear due to time, resource and coordination concerns. It is about implementing a care planning benefit and does not treat, cure or prevent Alzheimer's disease.
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The aging population is increasingly affected by both diabetes mellitus and hearing loss, two conditions that often coexist and can significantly impact quality of life.
Why it matters
This review discusses how diabetes and hearing loss may coexist and contribute to cognitive decline, exploring mechanisms such as mitochondrial dysfunction, neuroinflammation, oxidative stress and microangiopathy. It presents no new treatment or prevention trial results and does not test whether treating either condition reduces dementia risk.
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26% of the participants experienced delirium prior to diagnosis of DLB, with one participant experiencing multiple episodes in the 24 months before diagnosis.
Why it matters
In this small case series, 26% of people with dementia with Lewy bodies had delirium before diagnosis, and those cases progressed to dementia faster. This is a retrospective case series, so it can only suggest delirium as a possible early marker, not a treatment or cure.
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The TLC study used an appropriate design and data collection procedures, along with acceptable recruitment capability.
Why it matters
This mixed-methods feasibility study found the web-based TLC caregiver intervention had high usability and acceptability ratings among participants and respite providers. It is a feasibility study of a respite resource for caregivers, not a test of any treatment, cure or prevention for dementia.
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Four themes were identified, along with eleven sub-themes associated with them: cognitive-behavioral shift (transitioning family roles, recognizing disease characteristics, focusing on health management, and responding positively and effectively); personal strength enhancement (enhancing coping capacity, increased psychological resilience and increased responsibility); improved relationships with others (harmonizing in family relations and benefiting from social interactions); and changes in life perceptions (reshaping of values, and reconstructing the meaning of life).
Why it matters
This qualitative study identified themes of post-traumatic growth among family caregivers of people with dementia, including cognitive-behavioral shift, personal strength enhancement, improved relationships, and changes in life perceptions. It concerns caregiver experience and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Mild cognitive impairment (MCI) represents an initial phase of memory or other cognitive function decline and is viewed as an intermediary stage between normal aging and Alzheimer's disease (AD), the most prevalent type of dementia.
Why it matters
This study developed a machine learning model using blood gene expression and copy number variation data that classified MCI patients from normal controls with an AUC of 0.9398. The work is about developing a non-invasive diagnostic prediction tool and does not test any treatment or prevention.
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36/100
As the rates of Alzheimer's disease (AD) and AD and related dementias (ADRD) in the United States steadily rise, so too does the demand for informal caregiving.
Why it matters
This perspective highlights the multifaceted burden on informal Black male dementia caregivers and the lack of research focused on them. It calls for better support for this group and does not address treating, curing, or preventing Alzheimer's disease.
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There were weak or no correlations between the KICA-Cog and other cognitive assessment tools.
Why it matters
In urban-dwelling older Aboriginal Australians, the KICA-Cog showed weak or no correlation with other cognitive tests and has limited ability to detect mild neurocognitive disorder, and many participants had possible depression or anxiety. This is about improving assessment tools for dementia prevention programs, not about treating or curing the disease.
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Of the 74 patients examined, 19 (25.7%) experienced delirium, while 55 (74.3%) showed no symptoms of delirium.
Why it matters
Among 74 COPD patients in intensive care, about one in four developed delirium, and delirium was linked to older age, lower GCS scores, and lower PaO2 levels. This is a small single-center study about identifying risk factors, not about treating or preventing Alzheimer's disease.
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36/100
Potentially inappropriate medication (PIM) use-defined as the use of high-risk medications that can increase the risk of adverse events such as physical, cognitive, and functional decline; delirium; hospitalizations; and mortality-remains a significant concern in older adults in the US.Numerous guidelines, including the American Geriatrics Society Beers Criteria 1 and the STOPP criteria, 2 define PIMs as medications for which the risk of adverse effects outweighs potential benefits or are inappropriate for specific populations or disease states, such dementia or kidney disease.PIM use may be particularly harmful in populations experiencing other health care disparities, as communities experiencing other consequences of health care inequity, including limited access to physicians or pharmacies, greater financial stress, and a higher comorbidity burden, may experience disproportionate effects from the adverse consequences of PIM use.
Why it matters
This commentary discusses potentially inappropriate medication use in older adults, including harmful drug-disease interactions in patients with dementia, and racial and ethnic disparities in such use. It is about medication safety and deprescribing, not about treating, curing, or preventing Alzheimer's disease.
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Remote monitoring (RM) technology can support home-based dementia care by enabling (in)formal caregivers to monitor the health and safety of people with dementia remotely.
Why it matters
This study developed business models for remote monitoring technology to support home-based dementia care in the Netherlands. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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This paper explores the role of CSR in risk mitigation within an increasingly ESG-focused environment.
Why it matters
This paper is about corporate social responsibility and firm risk, not Alzheimer's disease, so it provides no information on Alzheimer's treatment, cure or prevention. It reports that CSR was associated with reduced firm risk across the models and measures used.
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Sixty studies were identified. Mental and physical effects caused by caregivers' sleep deprivation have been observed.
Why it matters
This scoping review of 60 studies found that sleep deprivation in dementia caregivers is linked to mental and physical effects in caregivers and to mental health indicators like depression and behavioural change in people with dementia. It underscores the need for adequate caregiver rest and interventions targeting sleep, but it did not test any intervention.
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The present study addresses the perspectives of Israeli family caregivers and migrant care workers on behavioral problems of persons with dementia.
Why it matters
This qualitative study of interviews with 21 migrant home care workers and 17 family members in Israel found that both groups had quite similar perspectives on the most challenging dementia behaviors and ways to address them. It offers insights for preparing family members and care workers, but does not test any treatment, cure or prevention for Alzheimer's disease.
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Enrollment of participants began on April 23, 2023.
Why it matters
This is a protocol for a randomized controlled trial that will test whether weighted blankets affect agitation in hospitalized patients with dementia. Enrollment is ongoing, with data collection anticipated to finish by March 2026, so no results on treating, curing or preventing Alzheimer's disease are available yet.
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36/100
No statistically significant differences emerged between SDW and GW groups regarding baseline demographics, cognitive function, ADL, or neuropsychiatric symptoms.
Why it matters
In this comparison of a specialized dementia ward with a general ward, there were no statistically significant differences in cognitive function, activities of daily living, or neuropsychiatric symptoms at four weeks, and the shorter length of stay was not significant. A significantly higher proportion of specialized ward patients were discharged home, so the main finding is about discharge destination rather than treating or curing Alzheimer's disease.
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Fifteen papers were included. Studies focused on educational and system change to improve the care of people with DSD.
Why it matters
This scoping review of 15 papers found varied evidence on the effectiveness of interventions involving family carers of patients with delirium superimposed on dementia in hospital. Benefits to patients over time were less clearly demonstrated, and further research is needed.
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The construction sector is among the most dangerous industries, recognized for its significant rate of accidents with even more serious consequences, especially in developing countries.
Why it matters
This study is about occupational accidents in the construction sector in Türkiye and contains no information on Alzheimer's disease. It reports no findings relevant to treating, curing or preventing dementia.
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The continuous declining rate of birth may cause severe worldwide problems, including population ageing and demographic imbalance.
Why it matters
This study models extreme low birth rates in U.S. counties and their links to factors such as population age and education. It does not address treating, curing or preventing Alzheimer's disease.
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Compared to persons without IDD, cumulative incidence of dementia was on average 4.27 and 5.33 times higher in persons with Non-DS IDD and DS respectively and period prevalence of dementia was on average 4.87 and 5.93 times higher in persons with Non-DS IDD and DS respectively.
Why it matters
This study found that dementia incidence and prevalence were several times higher in people with intellectual and developmental disabilities, including Down syndrome, than in people without. The authors call for early dementia screening and appropriate health and social services for this population.
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Mean performance on knowledge of dementia risk factor mitigation strategies significantly increased after viewing the animation (p < .001), with a clinically meaningful effect (mean change = 3.63).
Why it matters
This before-and-after survey found that viewing a culturally adapted dementia prevention animation in most languages increased knowledge of dementia risk factor mitigation strategies. It measured knowledge only, not whether dementia risk, treatment, or outcomes actually changed.
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36/100
The findings revealed that Japanese physicians did not display support for euthanasia (2%) and assisted suicide (1%); however, the general public supported euthanasia (33%) and assisted suicide (34%).
Why it matters
This study examined attitudes toward assisted dying among Japanese physicians and the general public, finding physicians were far less supportive than the public. It does not address treating, curing, or preventing Alzheimer's disease.
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Improving early detection, management, and treatment of comorbid conditions to dementia in residential care could slow down cognitive and functional decline, and increase residents' quality of life.
Why it matters
This expert consensus exercise identified mental illnesses, delirium, and sensory impairments as the most difficult comorbidities to manage in residential dementia care, along with medication management, staff shortages, and lack of training. It does not test any treatment or cure, but points to where care practices could be improved.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Can annual wellness visits reduce disparity in early dementia diagnosis?
- Recommendations of the Alzheimer's disease-related dementias conference
- Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK
- Race, Ethnicity, and Other Risks for Live Discharge Among Hospice Patients with Dementia
- Safety, Cognitive, and Behavioral Outcomes in Patients with Dementia with Lewy Bodies Treated with Nilotinib
- Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort
- Incidence and predictors of advance care planning among persons with cognitive impairment
- Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline
- Subjective memory complaints and cognitive impairment in older people
- Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes Over Time