Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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In stroke- and dementia-free individuals, higher 10-year risk for stroke is associated with performance decrements in multiple cognitive domains.
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Caregiver management strategies would appear to be associated with behavioural problems in dementia, and are important in predicting patient behaviour and caregiver burden.
Why it matters
This study found that caregiver management strategies were associated with behavioral problems in dementia, with non-adapters reporting significantly more hyperactivity symptoms in patients. It suggests that caregiver characteristics and strategies are important in predicting patient behavior and caregiver burden.
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The term dementia refers to a clinical syndrome of acquired intellectual disturbances produced by brain dysfunction.
Why it matters
This review notes that long-term heavy alcohol use is related to alcohol dementia, while light to moderate intake might reduce dementia risk. As a review of observational results, it cannot establish that drinking alcohol prevents Alzheimer's disease.
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A rehabilitation program of 6 weeks, including both motor and cognitive training, was applied to 20 patients affected by Parkinson's disease (PD) in the early stages, presenting with mild cognitive deficits, but no dementia.
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Some herbs are medically useful, but the American public would benefit from increased regulation.
Why it matters
This review of herbs commonly used by women reports that ginkgo biloba seems to slow the progression of dementia but increases the risk of bleeding. It summarizes limited evidence on one herb and does not establish a treatment, cure, or prevention for Alzheimer's disease.
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Using a stress process model, risk factors (caregiving stressors, caregiver health, and negative social interactions) and protective factors (caregiving appraisals and social resources) were examined as predictors of family caregiver well-being (depression and life satisfaction).
Why it matters
For caregivers of hospice patients with dementia or lung cancer, the amount of care provided and the patient's impairment did not strongly predict caregiver depression or life satisfaction. Instead, caregivers who found meaning in caregiving and stayed active in social roles had lower depression and higher life satisfaction, suggesting counseling could focus on these areas.
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Patients with major depression may have structural abnormalities of the hippocampus that can be detected by analysis of hippocampal shape but not volume.
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The average age at onset of first symptoms was 57.8 years.
Why it matters
This study described characteristics of 50 patients with frontotemporal dementia and compared their cognitive profile with severity-matched patients with Alzheimer's disease. It concerns frontotemporal dementia and cognitive testing, not Alzheimer's treatment, cure or prevention.
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Goal To assess the number of chronic hepatitis C patients eligible for therapy.
Why it matters
This study found that only 32 of 100 chronic hepatitis C patients were eligible for therapy, with hazardous alcohol consumption and psychiatric disorders common. It does not address treating, curing or preventing Alzheimer's disease.
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The risk of PSD is high, and increased in patients with prestroke cognitive decline, with about one-third of patients meeting the criteria for AD and two-thirds meeting the criteria for VaD.
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Even after adjustment for certain clinical attributes, individual social factors and local market factors were associated with survival after hospice enrollment.
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In the mature brain, chronic alcohol use disorders are associated with graded global brain dysmorphology.
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Twelve cases of dementia were diagnosed among individuals with scores below cutoff point and one among subjects with high scores.
Why it matters
This Colombian population study tested a Spanish version of the Mini-Mental State Examination and found sensitivity of 92.3% and specificity of 53.7%, with scores closely correlated with level of education. It is about a diagnostic screening test, not about treating, curing, or preventing Alzheimer's disease.
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Evidence is reviewed for a developmentally-emerging behavioral phenotype in individuals with Down syndrome that includes significant delay in nonverbal cognitive development accompanied by additional, specific deficits in speech, language production, and auditory short-term memory in infancy and childhood, but fewer adaptive behavior problems than individuals with other cognitive disabilities.
Why it matters
This 2000 review describes a developmental profile seen in Down syndrome: significant delay in nonverbal thinking skills, plus specific weaknesses in speech, language production and auditory short-term memory in childhood, though with fewer everyday adaptive-behaviour problems than in other cognitive disabilities. It reports that evidence of dementia appears in up to half of the individuals studied after age 50, which is why this group matters to Alzheimer's research. It discusses possible genetic explanations and the difficulty of choosing comparison groups, but it reports no new trial and tests no treatment or prevention.
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These findings are consistent with smaller left hippocampal volume in depression.
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43/100
We surveyed the medical records of outpatients meeting the NINCDS-ADRDA criteria for probable DAT who were able to complete the Cognitive Difficulties Scale (CDS) and had a close informant relative (IR) who could complete the family form of the same questionnaire.
Why it matters
This study looked at how aware people with mild Alzheimer's disease are of their own cognitive difficulties by comparing their reports with those of a close relative. It is about awareness of symptoms and does not test any treatment, so it says nothing about curing or preventing Alzheimer's disease.
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There have, however, been few studies which have sought to investigate factors associated with carer burden and differences and similarities between countries.
Why it matters
This cross-national study examined factors linked to burden and mental distress in spouse carers for people with Alzheimer's disease. It is about caregiver burden and suggests ways to prevent burden, not about treating, curing, or preventing Alzheimer's disease itself.
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The present investigation examined the validity of the revised Hopkins Verbal Learning Test (HVLT-R).
Why it matters
The revised Hopkins Verbal Learning Test was valid for measuring verbal learning and memory, and normal controls scored better than patients with probable Alzheimer's disease or vascular dementia. Its delayed recognition task was the most useful measure for telling Alzheimer's disease patients apart from those with vascular dementia.
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These data show that smaller hippocampal volumes are present from the onset of illness.
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The diagnosis of dementia is based on the presence of memory deficits and decline of other cognitive functions.
Why it matters
This study aimed to determine the best cut-off point of the Mini-Mental State Examination for diagnosing dementia in a Brazilian sample. It is a diagnostic accuracy study and provides no information on treating, curing or preventing Alzheimer's disease.
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TPM may be useful in patients with mood disorders unresponsive to traditional therapy and warrants further clinical investigation.
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Those who did not complete the dialysis-specific living will chose not to because they were not sure what they would want done (12 of 16 patients [75%]).
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We conducted two studies with medically hospitalized cancer and acquired immunodeficiency syndrome (AIDS) patients to assess the reliability and validity of a new measure of delirium severity, the Memorial Delirium Assessment Scale (MDAS).
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Volumetric measures in a group of patients with traumatic brain injury who had received MR imaging 3 months or less after injury were compared with measurements in other patients in the chronic phase of recovery.
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The daily rhythm in serum melatonin levels was measured in patients with dementia of the degenerate type (Alzheimer's disease, Pick's disease and senile dementia of the Alzheimer type) by radioimmunoassay.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Advance Care Planning in Cognitively Impaired Older Adults
- Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial
- Accuracy of dementia diagnosis: a direct comparison between radiologists and a computerized method
- White matter hyperintensities, cognitive impairment and dementia: an update
- A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia
- MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study
- Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies
- Machine Learning to Detect Motor Agitation in People With Dementia Using Real-Time Location Data
- Inequalities in dementia incidence between six racial and ethnic groups over 14 years
- Why Is Community-Based Palliative Care Declined? Older Adult, Caregiver, and Provider Perspectives