Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The DMN is the highest coverage of brain network regarding changes in local brain activity in patients with MCI.
Why it matters
This study found that people with mild cognitive impairment showed significant aberrant lateralization of spontaneous brain activity within the default mode network. The authors suggest this aberrant activity might be a specific imaging marker for improving mild cognitive impairment diagnoses, not a treatment.
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The program demonstrated good acceptability, adoption, and fidelity and was effective in instigating behavior change.
Why it matters
A community dementia screening program in rural Kenya was feasible and acceptable, and people who screened positive were 28.7 times more likely to intend to speak to a doctor. The authors say future research is needed on the long-term benefits of dementia screening, so this does not show a treatment, cure, or prevention.
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Twenty-five studies met the inclusion criteria.
Why it matters
This review of 25 studies describes practical ways to run Namaste Care in nursing homes, such as staff training, dedicated spaces, and family and volunteer involvement. It reports opportunities to improve quality of life and reduce behavioural symptoms for residents with advanced dementia, but does not test a cure or prevention.
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Twenty-six participants participated in the formal semi-structured interviews.
Why it matters
This qualitative study identified barriers to self-management among older adults with mild cognitive impairment, including misconceptions, self-neglect, and lack of information or support services. Tailored interventions addressing these barriers could help slow potential progression to dementia, but no treatment is tested.
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Climate change and associated disaster risks are contemporary issues of global concern.
Why it matters
This paper is about integrating disaster risk reduction into school curricula, not Alzheimer's disease. It reviews how school curricula can build disaster resilience and recommends holistic frameworks guided by disaster risk reduction education dimensions.
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Cardiovascular diseases (CVDs) remain the main cause of mortality and are generally among the leading causes of morbidity worldwide, thus placing an immense burden on health care.
Why it matters
This review describes cardiovascular disease epidemiology, risk factors, and prevention strategies in Saudi Arabia. It does not address Alzheimer's disease.
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average annual dementia incidence in White, but not Black, adults (1% versus 0%), due to hypertensive individuals' greater survival, and reduce annual ASCVD events more in Black than White adults (13% versus 5%).
Why it matters
A simulation found that tighter population-level blood pressure control would not reduce population-level disparities in dementia between US Black and White adults. It did not substantially reduce lifetime dementia risk in either group because people lived longer.
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Multivariate correlation analysis, which was adjusted for age, sex, and education level, revealed a significant correlation between the two tests in orientation, memory, and attention.
Why it matters
This study found that some subtests of the Korean Cognitive Impairment Screening Test correlated with the Korean MMSE-2 in orientation, memory, and attention, but not in visuospatial and language functions. Caution is advised when interpreting visuospatial and language scores from this test.
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38/100
Traumatic brain injury (TBI) is one of the main mechanisms underlying health issues associated with functional and structural brain changes.
Why it matters
This review describes how traumatic brain injury may lead to dementia-like neurodegeneration through mechanisms including neuroinflammation, oxidative stress, and protein buildup, and notes that risk is increased after moderate-to-severe injury. Current management focuses on symptom relief, and no treatment to prevent dementia after injury is established.
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Twenty-four studies were identified and confirmed that patients with dementia frequently resort to the ED near the end of life, frequently more than once in their last year of life.
Why it matters
This review of 24 studies found that people with dementia often go to the emergency department in their last year of life, often more than once, and that access to palliative care is low. It does not test any treatment, cure or prevention.
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Poststroke cognitive impairment (PSCI) refers to any level of cognitive decline occurring after a stroke, ranging from mild to severe impairments, while PSCI with dementia describes a more severe form where the cognitive decline significantly affects daily functioning and meets the clinical criteria for dementia.
Why it matters
This review notes that poststroke cognitive impairment is common but pharmacotherapy options are limited, with cholinesterase inhibitors and memantine showing inconsistent effectiveness across studies and populations. Newer drugs such as citicoline, cilostazol and antidepressants show promise but need further research to confirm their efficacy and safety for this condition.
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Our study highlights the potential of Decipher‐AI for screening undiagnosed cognitive impairment in primary care.
Why it matters
An AI algorithm called Decipher-AI was developed to screen primary care patients for undiagnosed cognitive impairment, and it showed no significant differences in performance across sex or race/ethnic subgroups, though performance was lower for patients under 75 and disparities were linked to fewer encounters and cognition-related notes in patients from disadvantaged neighborhoods. This is about finding undiagnosed cognitive impairment with a computer tool, not about treating, curing, or preventing Alzheimer's disease.
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Neighborhood deprivation is associated with Future research should investigate the possible mechanisms of this association to identify optimal interventions at the neighborhood level.
Why it matters
This study examined whether neighborhood deprivation was linked to subjective and objective measures of cognitive impairment in midlife adults. It does not test any treatment, cure or prevention, and the results describe associations rather than causes.
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In a national database of Medicare claims, there were substantial secular trends and differences in coding of dementia subtypes by race/ethnicity, sex, and neighborhood socioeconomic status.
Why it matters
This study of nationwide Medicare claims from 2014 to 2021 examined trends in diagnosis of dementia subtypes by race, ethnicity, sex, and neighborhood socioeconomic deprivation. It describes how dementia is coded and diagnosed in routine practice and does not test any treatment, cure, or prevention.
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Contrary to expectations, high versus low ADI groups only showed a difference in hippocampal volume, but in the reverse direction.
Why it matters
Among 310 patients with memory impairment, those living in the most disadvantaged neighborhoods had a 13.9% difference in hippocampal volume compared to those in the least disadvantaged areas. Other brain measures did not differ significantly, and the study cannot show that neighborhood conditions cause these brain changes.
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These preliminary findings reveal white matter alterations associated with consensus MCI diagnosis and to socioeconomic differences in a clinical cohort of rural‐dwelling older adults.
Why it matters
In a rural aging cohort, both a diagnosis of mild cognitive impairment and greater neighborhood disadvantage predicted differences in white matter microstructure on brain scans. The authors describe these as preliminary findings, and the study does not test any treatment or prevention.
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Overall, 3.3% of beneficiaries switched to MA annually.
Why it matters
This study found that Medicare beneficiaries who recently switched from Medicare Advantage to fee-for-service were more likely to switch back to Medicare Advantage, with similar patterns for those with and without Alzheimer's disease and related dementias. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Spending at end of life (EOL) accounts for a large and growing share of healthcare expenditures in the US, and often reflects aggressive care with questionable value for dying patients.
Why it matters
This study found that billed advance care planning services substantially increased hospice use and hospice spending within a year, with impacts especially prominent among patients with dementia. It concerns end-of-life care and spending, not treating, curing, or preventing Alzheimer's disease.
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The Mississippi Healthy Aging Data Report (see healthyagingdatareports.org) has helped policymakers, service providers, and advocates better understand the status of healthy aging in Mississippi.
Why it matters
This report describes county- and state-level indicators of healthy aging in Mississippi, where about 12.9% of Medicare beneficiaries have Alzheimer's disease or a related dementia. The report is intended to help policymakers and providers target efforts and support age-friendly systems.
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There are many studies of medical costs in late life in general, but nursing home residents' needs and the costs of external medical services and interventions outside of nursing home services are less well described.
Why it matters
This study examined medical costs of Swedish nursing home residents in their last year of life, adjusting for diagnosis of dementia or advanced cancer among other factors. It concerns costs, not treating, curing, or preventing Alzheimer's disease.
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38/100
Conversely, longer travel times to service providers were linked to use of fewer community-based services (B = -0.21, p < .001).
Why it matters
This study found that informal support from family or friends was linked to more use of home-based services, while longer travel times to providers were linked to less use of community-based services, among dementia caregivers in rural Appalachia. It does not test a dementia treatment or prevention, so it cannot show how to cure or prevent dementia.
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Mammogram utilization was 16% higher (Prevalence Ratio [PR] 1.16; 95% CI: 1.05, 1.29) among Medicare Advantage enrollees with dementia, compared to their counterparts in fee-for-service Medicare.
Why it matters
This study found that mammogram use was higher among Medicare Advantage enrollees with dementia than fee-for-service Medicare enrollees, especially among dual-eligible or urban enrollees, with no significant difference in rural areas. It noted that some Medicare Advantage enrollees with dementia may have experienced over-screening for breast cancer.
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The Healthcare Effectiveness Data and Information Set provides the dominant quality measurement framework for Medicare Advantage and commercial health plans, yet HEDIS lacks validated geriatric-specific quality indicators, equitable measurement standards for diverse older adult populations, and governance controls calibrated to the high-stakes Star Ratings financial incentive context.
Why it matters
This paper proposes a governance framework for geriatric quality measures, including cognitive impairment screening, in Medicare Advantage plans. It does not address treating, curing, or preventing Alzheimer's disease.
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The number of individuals with anorexia ranged from 317,964 to 328,977 per year, a mean annual prevalence rate of 1.1%.
Why it matters
About 1% of Medicare fee-for-service beneficiaries were diagnosed with anorexia each year, and dementia was among the most common comorbidities in that group, which had higher annual mortality than those without anorexia. This describes the health profile of people with anorexia, not any treatment, cure or prevention of Alzheimer's disease.
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The results of anonymous surveys conducted among the clinic9s providers are reported as descriptive findings.
Why it matters
This study assessed the feasibility and acceptability of a telemedicine memory care system during COVID-19. It concerns care delivery, not treating, curing, or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- An open trial of olanzapine for the treatment of delirium in hospitalized cancer patients
- Changes in sleep dimensions, cognitive transitions, and incident dementia: a two-cohort longitudinal study
- The UK Biobank resource with deep phenotyping and genomic data
- Association between zinc deficiency and adverse outcomes in patients with dementia: a matched cohort study
- Association of vitamin E and C supplement use with cognitive function and dementia in elderly men
- Association of Sleep Variables With Cognitive Performance and the Risk of Dementia in the Sleep and Dementia Consortium
- Medicare Hospice Policy Changes and Beneficiaries' Rate of Live Discharge and Length-of-Stay
- The Costs of Dementia From the Societal Perspective: Is Care Provided in the Community Really Cheaper Than Nursing Home Care?
- Time until institutionalization and death in patients with dementia. Role of caregiver training and risk factors
- Dementia caregiver intervention research: in search of clinical significance