Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The reanalyzed study population (aged 70 year and above) was composed of Central and North-Eastern Spanish sub-populations obtained from 9 surveys and totaled 12,232 persons and 1,194 cases of dementia (707 of Alzheimer's disease, 238 of vascular dementia).
Why it matters
This reanalysis found that dementia and Alzheimer's disease prevalence in Central and North-Eastern Spain is higher in females, increases with age, and shows considerable geographic variation that may be method-related. It estimates that people with dementia and Alzheimer's disease in Spain may approach 600,000 and 400,000 respectively, but notes that existing studies may not be completely appropriate to infer prevalence until surveys in Southern Spain are conducted.
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Comanagement by geriatricians and orthopedic surgeons, combined with standardized care, leads to improved processes and outcomes for patients with hip fractures.
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The results suggest that education is robustly associated with level of cognitive function but not with rate of cognitive decline and that the former association primarily accounts for education's correlation with risk of dementia in old age.
Why it matters
In more than 6,000 older Chicago residents tested about every 3 years for up to 14 years, people with more education scored higher on memory and thinking tests at the start, but their scores did not fall at a measurably different rate. The pattern was similar in black and white participants and was not explained by people improving with repeated testing. The authors conclude that education's link to dementia risk mainly reflects this higher starting level. The study was observational and tested no treatment or prevention.
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Family caregivers of people with dementia, often called the invisible second patients, are critical to the quality of life of the care recipients.
Why it matters
This review reports that psychosocial interventions have been shown to reduce caregiver burden and depression and delay nursing home admission for people with dementia. It does not test any treatment, cure, or prevention for Alzheimer's disease itself.
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48/100
The Brief COPE is a self-completed questionnaire measuring coping strategies.
Why it matters
This study tested the reliability and validity of the Brief COPE questionnaire in family carers of people with Alzheimer's disease. It is a measurement study and does not test any treatment, cure, or prevention.
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48/100
Contrary to some prior reports, behavioral variant frontotemporal dementia (bv-FTD) patients who progress over time are typically impaired on executive tasks at first presentation, although an important minority of true FTD patients perform normally.
Why it matters
This study found that patients with behavioral variant frontotemporal dementia who progressed over time were typically impaired on executive tasks at first presentation, while nonprogressors performed within the normal range. It may help distinguish these two groups, but it does not test any treatment, cure, or prevention.
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The low likelihood of patients with cAF in general practice remaining on treatment long-term indicates that not all benefits as observed in clinical trials may be achieved in usual clinical practice.
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This review reinforces the importance of providing appropriate palliative care to individuals suffering from end-stage dementia and identifies some of the barriers to extending such specialist palliative care provision.
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In this group of older adults free from neurodegenerative diseases, a greater variability of step length was associated with greater burden of subclinical brain vascular abnormalities as defined by MRI.
Why it matters
This study found that greater variability of step length was associated with greater prevalence of infarcts and greater white matter hyperintensities severity in high-functioning older adults free from dementia. It is about gait and subclinical brain vascular abnormalities and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Recent research has shown an increased rate of conversion to dementia in subjects with mild cognitive impairment (MCI) compared to controls.
Why it matters
In 56 people with mild cognitive impairment followed for about 37 months, those who progressed to dementia showed atrophy in certain brain regions at baseline. This supports using brain imaging to help predict conversion, but it does not test any treatment.
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Watching the video significantly changed preferences for care, transcending apparent differences in preferences associated with race/ethnicity and educational level.
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Caring for elderly people with dementia is associated with well-documented increases in burden, distress, and decrements in mental health and wellbeing.
Why it matters
This 2006 review reports that caring for someone with dementia is associated with higher burden and distress and with poorer mental health, and that burden and distress are higher with more severe behavioural, cognitive or functional problems in the person cared for, with more care hours and tasks each week, and with fewer coping and support resources. The authors say evidence-based interventions to ease carer distress exist but are held back by cost and policy barriers. It is about carers' wellbeing, not about treating or preventing Alzheimer's disease.
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Human immunodeficiency virus (HIV)-associated cognitive impairment, a significant cause of morbidity, affects up to 30% of HIV-infected people.
Why it matters
This cross-sectional study found that 77.6% of a group of 49 HIV-positive Hispanic women in Puerto Rico had some form of cognitive impairment, including 28.6% with HIV-associated dementia. It is a small study in one population and does not test any treatment or prevention for Alzheimer's disease.
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48/100
This study identifies predictors of complicated grief for which interventions could be developed to not only ease caregiver distress, but also serve as preventive interventions for bereavement.
Why it matters
In 217 caregivers who experienced the death of their care recipient, 20% showed complicated grief along with high levels of depressive symptoms after the death. This prospective study identifies predictors of complicated grief in bereaved dementia caregivers and does not address treating, curing, or preventing Alzheimer's disease.
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A strategy of targeting type-specific BPSD may be beneficial, such as environmental stimulus control for DLB patients who are prone to have hallucinations, design of a pacing path for patients with FTD who need support for symptoms of wandering and emotional support for patients with VaD who are susceptible to depression.
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Recently, the relationship between cognitive status and the neuropathological stages of a newly proposed staging procedure for Parkinson's disease (PD) was assessed in a cohort of 88 individuals.
Why it matters
This study examined the relationship between cognitive status and the neuropathological stages of Parkinson's disease in 88 individuals by looking at Lewy body pathology in the brain. It is about Parkinson's disease and does not test any treatment, so it says nothing about curing or preventing Alzheimer's disease.
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Numerous factors need to be taken into account when managing a patient with Parkinson's disease (PD) after deep brain stimulation (DBS).
Why it matters
This report gives guidance on managing problems that can arise after deep brain stimulation in Parkinson's disease, including cognitive problems and the development of dementia. It does not test a treatment, cure or prevention for Alzheimer's disease.
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A heterogeneous community sample (n=371) of predominantly ethnic minority elderly assessed by standardized research protocol, 231 of whom met criteria for dementia or mild cognitive impairment (MCI).
Why it matters
This study found that a brief cognitive screen, the Mini-Cog, detected cognitive impairment much more effectively than the participants' own primary care physicians did. This is about improving recognition of cognitive impairment in primary care, not about treating, curing, or preventing Alzheimer's disease.
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48/100
Frontotemporal dementia (FTD) is a focal clinical syndrome characterised by profound changes in personality and social conduct and associated with circumscribed degeneration of the prefrontal and anterior temporal cortex.
Why it matters
This review describes frontotemporal dementia as a focal clinical syndrome with circumscribed degeneration of the prefrontal and anterior temporal cortex and notes that many cases show no apparent tau abnormality. It is a review, not a treatment, cure or prevention for Alzheimer's disease.
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The new MRI rating scale for WMH in cholinergic pathways is reliable and shows stronger correlations with cognitive performance than a general WMH rating scale in AD with WMH.
Why it matters
A new rating scale for white matter hyperintensities within cholinergic pathways was reliable and was associated with impaired performance on the Mattis Dementia Rating Scale, accounting for 12% of the variance. A similar model was not significant for general white matter hyperintensity scores.
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A profile of equal impairment on tests of executive control and memory along with radiologic evidence involving about one-fourth of the cerebral white matter as measured by the Leukoaraiosis Scale may be sufficient for a diagnosis of subcortical vascular dementia.
Why it matters
Neuropsychological measures accounted for 60.7% of the variance in white matter abnormality severity, with executive and visuoconstructive test performance contributing most. Only patients with mild white matter abnormalities showed greater impairment on memory and language tests than on executive control and visuoconstructive tests.
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Understanding variability in conceptions of dementia in multiethnic populations is important to improve care and guide research.
Why it matters
In a multiethnic sample of family dementia caregivers, 54% held explanatory models combining folk and biomedical elements, and minority caregivers were more likely to do so. This describes how families understand dementia and may help guide care and research, but it does not treat, cure, or prevent the disease.
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Little is known about the relative benefits of cognitively stimulating activities at different points in the lifespan.
Why it matters
In 576 older persons without dementia, past cognitive activity and resources were positively correlated with current cognitive activity and function, though the association with cognitive function was reduced after controlling for other factors. This is an observational study and does not show that cognitive activity prevents Alzheimer's disease.
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Cerebral small-vessel disease is common in older people and may contribute to the development of dementia.
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Although internal factors explain most about the poor nutritional status of aged residents in nursing homes, the factors related to nutritional care need further investigation to clarify their role in maintaining the nutritional status of aged residents.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- ICF Application and Assessment Tool Analysis for Dysphagia Evaluation in Patients with Dementia: A Scoping Review
- Palliative care integration in psychiatric disorders: bibliometric analysis revealing five distinct research clusters
- Using a distribution-based approach and systematic review methods to derive minimum clinically important differences
- Time‐dependent biomarker accuracy in forecasting mild cognitive impairment
- When home caregiving ends: a longitudinal study of outcomes for caregivers of relatives with dementia
- Whole Dietary Patterns, Cognitive Decline and Cognitive Disorders: A Systematic Review of Prospective and Intervention Studies
- Investigating the Utility of Explainable Artificial Intelligence for Neuroimaging‐Based Dementia Diagnosis and Prognosis
- The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics
- Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study
- Quetiapine to treat agitation in dementia: a randomized, double-blind, placebo-controlled study