Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Declines in adaptive behavior were examined in a study of dementia in adults with Down syndrome and other forms of mental retardation.
Why it matters
No significant differences in decline in adaptive behavior were found between adults under 50 with and without Down syndrome, but over 50 those with Down syndrome were more likely to be classified as having dementia. Prevalence estimates were substantially below the presumed 100% prevalence of neuropathological markers of Alzheimer's disease, a discrepancy the authors say may reflect differences in risk or a lack of correspondence between the hallmarks and clinical expression.
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38/100
Down syndrome remains one of the most common causes of mental retardation.
Why it matters
This review notes that Down syndrome carries an increased risk of Alzheimer's disease and is a useful model for studying aging. It describes improved medical care and functional outcomes for people with Down syndrome but reports no treatment, cure, or prevention for Alzheimer's disease.
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In its early stages, Parkinson's disease (P.D.) may be difficult to distinguish from major depression (M.D.) leading to inappropriate management.
Why it matters
This study used computerized acoustic analysis to compare speech patterns in Parkinson's disease and major depression, finding that major depression patients had significantly reduced rates of speech compared with Parkinson's disease patients. The authors suggest this temporal speech measure may help differentiate the two disorders.
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A study of 365 women aged 70-79 in a rural community was carried out using the Cambridge Examination of Mental Disorders in the Elderly (CAMDEX).
Why it matters
This study estimated how common dementia was in a rural population of elderly women. It found that overall prevalence rates were similar to other studies, but it does not test any treatment or cure.
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Increasing costs of institutional care for the aged have occasioned a variety of government cost containment measures.
Why it matters
This policy paper argues that cost containment measures and inadequate community services are shrinking care options for people with senile dementia of the Alzheimer's type. It concerns institutional care policy and funding, not treating, curing, or preventing Alzheimer's disease.
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Frailty in DS is associated with both ID severity and acquired cognitive decline.
Why it matters
In this cross-sectional study of 148 patients, greater frailty was associated with more severe intellectual disability and worse cognition, and acquired cognitive decline was associated with frailty regardless of cause. It identifies associations only and tests no treatment, cure, or prevention.
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Mild cognitive impairment (MCI) is a stage between normal cognition and dementia, and timely diagnosis of this condition offers the opportunity for effective interventions to slow down the progression to dementia.
Why it matters
This study found that the CANTAB Paired Associates Learning test showed good diagnostic accuracy for distinguishing mild cognitive impairment, though the small sample size may have influenced the results. It is about cognitive screening, not about treating, curing, or preventing Alzheimer's disease.
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= 0.002). A sharp transient increase occurred in 2020, attributable to pandemic-related factors including disproportionate COVID-19 mortality among older adults with neurodegenerative conditions, care disruptions, and changes in death-certificate coding practices.
Why it matters
This analysis of death-certificate data found significant temporal changes and demographic and geographic disparities in mortality involving co-recorded Parkinson's disease and dementia, with a sharp transient increase in 2020. The authors state these surveillance data cannot establish clinical co-occurrence, causal relationships, or individual disease risk, and no treatment, cure, or prevention was tested.
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The suppressed fraction rose with rarity: 7.4% of counties for breast, 61.3% for stomach, and 75.7% for cervix incidence.
Why it matters
This study is about cancer disparity estimates and suppression of small counts in U.S. counties, not Alzheimer's disease, so it does not provide information on treating, curing or preventing Alzheimer's. It found that the suppressed fraction of counties rose with cancer rarity.
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Artificial intelligence (AI) is rapidly expanding into dementia-related health and social care, with proposed applications ranging from early risk detection and monitoring to care coordination and service planning.
Why it matters
This perspective examines opportunities and challenges of AI in dementia care policy, focusing on equity, privacy, accountability, and the risk that technology displaces human care. It reports no treatment, cure, or prevention of Alzheimer's disease.
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We found significant county-level variability in utilization of high-quality home health.
Why it matters
This study found that people with dementia were less likely than those without dementia to receive home health care from agencies rated high on patient satisfaction, though not on clinical status measures. It concerns home health quality, not treating, curing or preventing Alzheimer's disease.
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LPA supported a three-profile solution: (1) lower depressive symptoms with moderate anxiety (33%), (2) severe combined depression and anxiety (18%) and (3) moderately severe depression with severe anxiety (49%).
Why it matters
This study grouped family caregivers of people with dementia into three profiles based on their depression and anxiety symptoms. It describes caregiver distress patterns but does not test any treatment for dementia itself.
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37/100
Dementia is a progressive condition that affects cognition, communication, mobility, and independence, posing growing challenges for individuals, caregivers, and healthcare systems.
Why it matters
This is a concept paper that proposes a framework for matching AI technologies to different stages of dementia and different areas of need, rather than reporting new treatments or cures. It does not present tested outcomes, so it offers a roadmap for future research rather than evidence that any AI tool prevents or treats Alzheimer's disease.
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The average MIND-NL scores for the short FFQ (8·4 ( sd 1·8) points) and food records (6·7 ( sd 1·7) points) showed to be significantly different ( P 0·20) were observed for 10 out of 15 MIND-NL diet components.
Why it matters
This study evaluated the validity of a short online food questionnaire for assessing adherence to a Dutch version of the MIND diet in older adults at risk of cognitive decline. It is a measurement validation study and provides no evidence about treating, curing, or preventing Alzheimer's disease.
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Three changes to the intervention content were determined from the different sources of data.
Why it matters
This participatory action research adapted an intervention for Latino family caregivers of people with dementia, adding content on dementia as a medical condition, self-care and transitional care resources. It concerns caregiver support and knowledge translation, not a treatment or cure for Alzheimer's disease.
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37/100
Across CTT studies, findings ranged from two-factor to hierarchical multi-factor models, with a general cognitive factor frequently emerging.
Why it matters
This review found that the MoCA primarily measures a general cognitive dimension, with Executive Function, Visuospatial, and Language items being the most discriminative, while Orientation and Memory showed low discriminative power. Standardizing scoring metrics and ensuring cross-cultural factorial equivalence are essential to enhance the tool's accuracy and interpretation.
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-weighted magnetic resonance images of 41,708 cognitively normal adults in the UK Biobank.
Why it matters
This genetic analysis of 41,708 cognitively normal adults identified 1,212 single-nucleotide polymorphisms associated with local brain aging and mapped top variants to genes including KCNK2, NUAK1, GMNC, and MSL2. The findings establish a polygenic architecture for regional brain aging and suggest local brain aging as a phenotype for studying neurodegeneration, but they do not test any treatment, cure, or prevention.
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Centers for Medicare and Medicaid Services (CMS) administrative data are among the most practical sources for understanding the incidence of dementia over time in older populations, but have yet to be widely used in intervention studies.
Why it matters
Using CMS and Maryland health information exchange data, 26% of 520 linked trial participants developed dementia over 14 years, showing that administrative data can classify incident dementia and its subtypes without in-person follow-up. This is a methods finding about tracking dementia in intervention studies, not a treatment, cure or prevention result.
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There were no significant differences in self-efficacy related to obtaining respite and RDPB between SES groups.
Why it matters
This study found no significant differences in caregiver self-efficacy for obtaining respite between socioeconomic status groups, but did find differences in other areas such as controlling upsetting thoughts. It suggests that insurance status, education, and employment may relate to caregiver self-efficacy, which could inform how support interventions are designed.
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All the five dimensional SDOH disadvantages were significantly associated with higher odds of both dementia and MCI in the overall sample (p <0.05) (Figure 1).
Why it matters
This study found that five types of social disadvantage were linked to higher odds of both dementia and mild cognitive impairment, with the strength of these links differing across racial and ethnic groups. It does not test any treatment, cure or prevention, but suggests that strategies addressing social determinants may need to be tailored to different groups.
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(n = 399) have completed the first follow-up assessments, including MoCA, mCAIDE, memory self-report, demographic information.
Why it matters
This study describes cognitive test scores, memory concerns, and demographic factors in a diverse rural Florida population, finding about half were at risk for Alzheimer's disease based on test scores. It does not test any treatment, cure, or prevention.
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PREDICTOM MRI protocol contains eight different datatypes.
Why it matters
This paper describes the design of the PREDICTOM MRI protocol, which includes eight datatypes and was created to explore existing and novel MRI biomarkers for early identification of people at high risk of developing Alzheimer's disease. It is a protocol design for early identification, not a treatment, cure, or prevention study.
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PREDICTOM MRI protocol contains eight different datatypes.
Why it matters
This paper describes the design of the PREDICTOM MRI protocol, which includes eight datatypes and was created to explore existing and novel MRI biomarkers for early identification of people at high risk of developing Alzheimer's disease. It is a protocol design for early identification, not a treatment, cure, or prevention study.
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So far, we included 42 patients in our study, that were monitored for at least 7 consecutive days and nights, to form the largest database of its kind in the world.
Why it matters
This ongoing study has monitored 42 patients with dementia for at least seven consecutive days and nights using multimodal sensing and machine learning to look for digital markers of agitation. It is early work about monitoring a symptom, not about treating, curing or preventing Alzheimer's disease.
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The MoCA Solo is emerging as a reliable and efficient tool for assessing cognitive impairment in older adults.
Why it matters
This usability study describes a digital AI-assisted version of the MoCA test for assessing cognitive impairment in older adults. It is a screening tool and reports no findings about treating, curing or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts
- Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
- Using virtual reality for cognitive training of the elderly
- Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies
- Excess hypoglycaemia-related hospitalisation in older adults with comorbid type 2 diabetes and dementia: a UK Biobank cohort study
- Gait stability and variability measures show effects of impaired cognition and dual tasking in frail people
- Geographic Variation in Inpatient Care Utilization, Outcomes and Costs for Dementia Patients Aged 65 Years or Older — China, 2017–2019
- Dementia after delirium in patients with femoral neck fractures
- Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes
- Prevention and Management of Delirium in the Intensive Care Unit