Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
Early detection of cognitive impairment in assisted living is hindered by time-intensive tools like MMSE and MoCA.
Why it matters
This study describes a 60-second voice-based model using picture descriptions that estimated dementia risk with an AUC of 0.858, exceeding MMSE, and was designed to be simple enough for mobile apps or in-room monitors. It is a screening tool for early detection, not a treatment, cure, or prevention of Alzheimer's disease.
-
The MIND diet may buffer the cognitive consequences of cerebrovascular pathology and cortical atrophy in older adults at elevated dementia risk and promote cognitive resilience over general healthy eating guidelines.
Why it matters
In this cross-sectional study of 66 older adults, higher MIND diet scores were linked to better memory performance, and the MIND diet appeared to weaken the link between brain pathology and cognition. This suggests the MIND diet may help protect thinking skills even when brain disease is present, though the study cannot prove cause and effect.
-
Counties had a mean prevalence of 65.3 per 1,000 (SD 15.5) for highly likely ADRD and 123.5 per 1,000 (SD 27.0) for all determinations.
Why it matters
This spatial epidemiological analysis found that county-level social vulnerability was linked to higher ADRD prevalence and mortality across US counties. It does not test any treatment, cure, or prevention for Alzheimer's disease.
-
Over a three-month period, MT+CST was more effective than CST alone in improving cognitive function but was not cost-effective due to higher initial costs, including setup and equipment.
Why it matters
Over three months, music therapy plus cognitive stimulation therapy improved cognitive function more than cognitive stimulation therapy alone but was not cost-effective due to higher initial costs. When cognitive benefits were assumed to last six months, it became cost-effective.
-
The burden of perioperative organ injury in China is significant even at a national level.
Why it matters
This commentary concerns perioperative organ injury in China's county-level hospitals and mentions delirium mortality, but it does not report findings on treating, curing, or preventing Alzheimer's disease.
-
376 323 elective geriatric THA patient samples from the NIS database were included, with an overall dementia prevalence of 2.05%.
Why it matters
In this analysis of 376,323 elective hip arthroplasty patients, dementia was independently associated with higher risks of perioperative complications and greater healthcare use. The findings support enhanced monitoring and multidisciplinary care, but they do not test any treatment, cure, or prevention for dementia.
-
Thirty articles met the inclusion criteria.
Why it matters
This scoping review found that anticipatory grief among caregivers of people with dementia was linked to being a spousal caregiver, greater caregiving involvement, caregiving stressors, and relationship changes, and was consistently associated with depressive symptoms. It addresses caregiver grief and does not test any treatment, cure, or prevention for Alzheimer's disease.
-
The model incorporating age, brain volume, functional, and radiomics features demonstrated the highest predictive performance for SCD progression in training (C-index: 0.962; 95 % CI: 0.95-0.98) and testing (C-index: 0.911; 95 % CI: 0.861-0.968) sets.
Why it matters
This study developed a model using age, brain volume, functional, and radiomics features from MRI that accurately predicted progression from subjective cognitive decline to mild cognitive impairment over 10 years. This could help identify individuals for monitoring or early intervention, but no treatment is tested.
-
Among the 1,035 patients in our dataset, 176 (17%) had a dementia diagnosis.
Why it matters
This study examined whether including dementia diagnosis or cognitive impairment improves prediction of home care costs. It found these factors did not materially improve prediction beyond daily living measures, which concerns cost prediction rather than treating, curing or preventing Alzheimer's disease.
-
A total of 83,807 articles were included for bibliometric analysis.
Why it matters
This bibliometric analysis of 83,807 articles identified geriatric and dementia care as one of five major thematic clusters in nursing-related digital and artificial intelligence technologies. It maps research trends and competency domains but reports no findings on treating, curing, or preventing Alzheimer's disease.
-
Early detection of Mild Cognitive Impairment (MCI) offers a critical window for intervention before progression to dementia.
Why it matters
This study used multimodal behavioral analysis during the Clock Drawing Test to screen for mild cognitive impairment, achieving high accuracy in distinguishing participants from controls. It is about improving screening and does not test any treatment, cure, or prevention.
-
38/100
Our results show that MA enrollees in PR have six percentage points higher ADRD rates than their US counterparts.
Why it matters
This study found that Medicare Advantage enrollees in Puerto Rico had a higher rate of Alzheimer's disease and related dementias diagnosis (15%) compared to mainland US counterparts (9%). It does not test any treatment, cure, or prevention for Alzheimer's disease.
-
Patients (N = 2,512) receiving lecanemab infusion had a mean age of 75.4 (standard deviation = 5.7) years as compared to 80.8 (8.9) years in patients with MCI/AD not receiving the infusion.
Why it matters
Among Medicare beneficiaries, those receiving lecanemab infusions were younger, more likely to be White, and had fewer other illnesses than those not receiving it, and most lived in urban areas. The study describes who is getting this treatment and where, not whether it works.
-
Diagnostic classifications, mean age, and education did not differ significantly across classifications.
Why it matters
This study found that different systems for classifying disadvantaged or rural areas in Kentucky showed different patterns of risk factors for cognitive impairment and dementia. It does not test any treatment, cure or prevention, but highlights that how we define disadvantage matters for research aimed at identifying high-risk groups.
-
Income was among the top risk factors for all three groups.
Why it matters
This machine learning study identified which social determinants of health were top risk factors for cognitive impairment in different ethnic groups. It does not test any treatment, cure, or prevention for Alzheimer's disease.
-
We used multilevel logistic regression with a random site intercept to test whether the probability of change in management associated with social determinants, race/ADI interactions with amyloid‐positivity, comorbidities, and clinical setting, adjusting for demographics.
Why it matters
Among 10,904 cognitively impaired participants, changes in Alzheimer's disease drug management were associated with dyslipidemia, depression, and tobacco use. Non-Alzheimer's drug management changes were associated with depression, group practice, and area deprivation index in amyloid-positive participants.
-
Among dementia patients, a PPH increased the risk of mortality by 4.7 percentage points (PP) (95% CI: 3.8%-5.6%).
Why it matters
Among Medicare beneficiaries with dementia, having a potentially preventable hospitalization was linked to a higher risk of death and long-term institutionalization. This concerns hospital care and outcomes, not treating, curing or preventing Alzheimer's disease itself.
-
Proportions defined as living in a rural or disadvantaged area varied by classification, ranging from 13% to 27% of the cohort.
Why it matters
This study compared different ways of classifying whether people live in rural or disadvantaged areas and found the classifications often did not overlap. It is about how researchers define rurality and disadvantage, not about treating, curing, or preventing Alzheimer's disease.
-
Delirium exhibited a metabolic profile of network dysfunction that may be modifiable and clinically responsive.
Why it matters
This study used FDG PET imaging to derive a delirium-specific metabolic pattern that distinguished acutely unwell patients with delirium from those without. The pattern showed higher expression in delirium and delirium superimposed on dementia, and recovery was paralleled by reduced expression, suggesting the metabolic profile may be modifiable and clinically responsive.
-
Although individuals with dementia who reside in nursing homes are particularly susceptible to developing delirium, this condition is rarely recognised in these settings.
Why it matters
This study protocol describes a planned assessment of the comprehensibility, practicality and inter-rater reliability of three delirium detection tools when used by nurses in German nursing homes. It aims to develop manuals for the tools and test them with 70 residents assessed by at least two nurses.
-
Validation was conducted across 94 households over 365 nights, totalling 297,297 monitoring hours.
Why it matters
This study tested a rule-based algorithm using ambient sensors to monitor night-time safety in households with dementia, and most alerts were validated as night-time going out events. It addresses safety monitoring and caregiver burden rather than treating, curing or preventing Alzheimer's disease.
-
Various missing codes were used to document reasons for missingness.
Why it matters
This paper describes that missing data rates in international Harmonized Cognitive Assessment Protocol studies were low, and item-level missingness was imputed using chained equations. The current practice worked well, and the authors include recommendations for best practices in study design, data collection, and reporting of imputed data.
-
38/100
In phase 1, the mean system usability scores increased from 65.4 (SD 11.8) in round 1 to 73.8 (SD 15.9) in round 3, exceeding the benchmark of 68.
Why it matters
Caregivers rated the CareBuddy mobile app highly for usability and satisfaction, and an ongoing trial is evaluating whether it improves caregiver outcomes. This study assessed app usability, not any treatment, cure, or prevention for Alzheimer's disease.
-
Among the participants, 298 had at least one untreated or uncontrolled VRF.
Why it matters
This trial found that a multidomain intervention produced cognitive benefits in people with untreated or uncontrolled vascular risk factors, but not in those without them. It does not show that the intervention prevents or treats Alzheimer's disease.
-
This study explores the scientific landscape linking the Mediterranean Diet Adherence Screener (MEDAS) to aging-related health outcomes through a comprehensive bibliometric and scoping review approach.
Why it matters
This bibliometric and scoping review found that fish, vegetables, nuts, and olive oil were the most studied components of a Mediterranean diet adherence questionnaire, with cardiovascular aging being the most researched domain. It does not provide evidence that the diet prevents or treats Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- The association between blood pressure, hypertension, and cerebral white matter lesions: cardiovascular determinants of dementia study
- Negative Consequences of Sleep Deprivation Experienced by Informal Caregivers of People With Dementia on Caregivers and Care Recipients: A Scoping Review
- Nutritional Status is Associated With Severe Dementia and Mortality
- Epidemiology of stroke in Europe and trends for the 21st century
- Cost containment by peer prior authorization program for second line treatment in patients with retinal disease
- Gay Men as Caregivers for Spouses with Dementia: Intersections of Gender and Sexual Orientation
- Consensus on quality indicators to assess the organisation of palliative cancer and dementia care applicable across national healthcare systems and selected by international experts
- Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
- The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: A systematic review and meta-analysis
- 10-year trajectories of depressive symptoms and risk of dementia: a population-based study