Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Central-northern rural communities exhibited the most pronounced high-high spatial clustering of cognitive impairment (Global Moran's I = 0.17, p < 0.001).
Why it matters
In rural Chinese communities, cognitive impairment among elderly hypertensive patients clustered geographically, with the highest burden in central-northern areas. Physical activity and adequate sleep showed protective effects that were consistent across all communities, while income, distance to major roads, and number of hospitalizations varied by location.
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More than 50% of older adults with AD/ADRD visit the emergency department (ED) each year [3, 4] and those who do are seriously ill, have significant healthcare costs (e.g., hospital admissions, repeat ED visits) and mortality [4-6].
Why it matters
This manuscript describes a planned multifactorial trial across 79 emergency departments testing three interventions focused on ED-to-home care transitions for people with dementia. It is a study design with no results yet on treating, curing or preventing Alzheimer's disease.
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EEG/ERP analysis suggested differences in frontal alpha asymmetry, power ratio, and ERP components between the MCI and CN groups.
Why it matters
Combining EEG, event-related potentials, and MRI features in a machine learning model classified mild cognitive impairment with 80.90% accuracy. These are candidate biomarkers for detection, and the authors support further validation in larger cohorts, not a treatment or cure.
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Black caregivers reported shorter sleep duration but lower daily pain than White caregivers.
Why it matters
This study of Black and White dementia caregivers found that greater sleep disturbances predicted higher morning pain, and that longer-than-usual sleep duration predicted lower next-day pain only among Black caregivers. The authors suggest sleep duration may be a beneficial intervention target for Black caregivers, but this concerns caregiver pain and sleep, not treating, curing, or preventing Alzheimer's disease.
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The Benson Complex Figure Test (BCFT) is a neuropsychological tool designed to assess visuospatial construction and visual memory with lower complexity than traditional tests.
Why it matters
The Benson Complex Figure Test showed distinct visuospatial and memory profiles across dementia subtypes, with good accuracy for common subtypes like Alzheimer's but low accuracy for rarer subtypes. This supports its potential use in differential diagnosis, but it is not a treatment or cure.
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Among 421,131 MA beneficiaries, telehealth use increased sharply in Q2 2020 for both ADRD and non-ADRD groups, peaking at 33.9 and 30.6% respectively.
Why it matters
This study described telehealth use among Medicare Advantage beneficiaries with and without dementia from 2018 to 2024. It found telehealth use rose sharply in 2020 and then declined, with a small sustained increase for those with dementia, which concerns access to care rather than treating or curing the disease.
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With the increased use of technological supports in residential care homes, there is growing interest in the use of real-time location systems (RTLS) to enhance safety and streamline care.
Why it matters
This paper critically examines ethical tensions around using real-time location systems in dementia care, focusing on autonomy, beneficence, non-maleficence and justice. It proposes recommendations such as continuous consent and ethical data use policies, but does not test any treatment, cure or prevention for dementia.
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Participants in the highest versus lowest MedDiet and MIND categories had 21% (hazard ratio [HR] = 0.79, 95% confidence interval [CI]: 0.73-0.84) and 14% (HR = 0.86, 95% CI: 0.81-0.91) lower dementia risk, respectively.
Why it matters
This observational study found that higher adherence to the Mediterranean and MIND diets was linked to lower dementia risk and slower cognitive aging. It cannot prove that these diets prevent or treat Alzheimer's disease.
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• Lower MMSE scores—even by a single point—were independently associated with a significantly higher risk of developing ADRD. • Individuals with MMSE scores between 27 and 30 should not be viewed as a uniform group. • Further studies are needed to find ways to prevent ADRD in people who are at risk but do not yet show symptoms.
Why it matters
In this long-term study of community-dwelling older adults with MMSE scores in the normal range of 27 to 30, each single point lower was linked to a higher risk of developing Alzheimer's disease and related dementias. The authors call for further studies on how to prevent these dementias in people at risk who do not yet show symptoms.
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Identifying older adults at increased dementia risk is a public health priority.
Why it matters
A risk score built from factors like diabetes, alcohol consumption, cholesterol, social participation and cognitive activity predicted dementia in adults aged 70 and older in two Italian cohorts. The score is a practical tool for risk stratification, but further studies are needed to test how well it works in other settings and populations.
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BackgroundThe yes-no reversal (YNR) phenomenon consists in a patient saying "yes" when meaning "no", or vice-versa.
Why it matters
This study found that the yes-no reversal phenomenon occurred in about 8.6% of patients, all of whom had dementia rather than mild cognitive impairment, and was more common in non-Alzheimer's etiologies. It describes a clinical sign and does not test any treatment.
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44/100
At baseline, nearly one-third of caregivers reported moderate-to-severe burden (mean ZBI 31.4 ± 15.4), a prevalence that persisted at 6 months.
Why it matters
This longitudinal dyadic cohort study found that nearly one-third of caregivers reported moderate-to-severe burden at baseline, which persisted at 6 months, and that neuropsychiatric symptoms were major correlates and predictors of burden, with some sex-specific patterns. The findings concern identifying at-risk caregivers and do not address treating, curing, or preventing Alzheimer's disease.
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A significant association between increased caregiver burden and BPSD in patients with AD was demonstrated, which may be associated with decreased caregiver healthcare and social care-related QOL.
Why it matters
In this web-based survey in Japan, caregivers of people with Alzheimer's disease who had behavioral and psychological symptoms reported higher burden and lower quality of life than those without such symptoms. The study was cross-sectional, so it shows an association and not cause and effect.
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This study highlights the role of age, gender, APOE genotype, and depressive symptoms in the presentation and progression of cognitive decline.
Why it matters
In 440 people with subjective cognitive decline followed for a median of 10 years, a machine learning model predicted progression to dementia with 74% accuracy, and features such as gender, cognitive reserve, subjective cognitive decline severity, and depressive symptoms were interconnected. This is a prediction and management-protocol study, not a treatment or cure.
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The caregivers in intervention group showed significant reductions in distress scores for dressing, personal hygiene, communication, and behavioural and psychological care problems at both the 6th and 12th week assessments.
Why it matters
In this randomized controlled trial, a mobile app-based recommender system reduced caregivers' distress over care problems and lessened caregiver burden at 6 and 12 weeks. Depressive symptoms did not improve significantly, and the authors say further research is needed on long-term effects and mechanisms.
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Treatment options for dementia mainly comprise of symptomatic treatment, as no disease-modifying therapy currently exists that directly reduces the pathology.
Why it matters
Only two eligible trials were found for this systematic review of neflamapimod (VX-745), a p38α kinase inhibitor, in Alzheimer's and Lewy body dementia. The main memory test scores did not differ from comparison groups, though some measures such as episodic memory and gait improved and spinal fluid tau markers fell significantly. The authors say its cognitive effects remain uncertain, but its effect on disease biomarkers makes it a possible candidate for further study.
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Of the n = 180 participants recruited, n = 77 participated in this study, n = 37 caregivers and n = 40 non-caregivers.
Why it matters
This pilot study describes strategies used to recruit and retain Black male caregivers and non-caregivers in dementia research. It does not test any treatment or prevention for Alzheimer's disease.
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DNS conditions, particularly dementia, were associated with longer survival among non-oncologic HBPC patients.
Why it matters
This retrospective cohort of 248 non-cancer patients in a Brazilian home-based palliative care program found diseases of the nervous system were the most frequent referral diagnoses, and patients with Alzheimer's disease and related dementias demonstrated longer survival than those with other or no such diagnoses. Predictive accuracy of the model was limited.
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44/100
Within one week after dcLVA, 64.3% of patients demonstrated MMSE improvement, with further functional gains observed in continence, emotional regulation, motor coordination, and feeding independence.
Why it matters
In this single-arm study, most patients with dementia showed MMSE improvement within one week after deep cervical lymphatic-venous anastomosis, and tau protein was found in all examined cervical lymph nodes. The authors state that the single-arm design prevents any conclusion that the surgery causes the improvements.
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Women living in areas with higher walkability showed slower rates of decline in immediate (estimate=0.019, SE=0.009) and delayed recall (estimate=0.018, SE=0.008) (Figure 1).
Why it matters
This study found that midlife women in more walkable areas had slower decline in episodic memory over 14 years, while healthy food environments showed no significant overall link to cognition but differed by racial/ethnic group. It suggests neighborhood features may influence cognitive decline, but it does not test a treatment or cure for Alzheimer's disease.
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Participants' age ranged from 45 to 87, 53% were women, and 26% were diagnosed with dementia (39% AD, 18% Lewy Body and 17% Frontotemporal Dementia; Table 1).
Why it matters
This cross-sectional study found that living in a more walkable neighborhood was linked to lower levels of some markers of neurodegeneration and inflammation, mainly in more deprived areas, and to lower amyloid burden in people already diagnosed with dementia. It cannot show cause and effect, and the authors say future research should explore the mechanisms linking walkability to brain and mental health.
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44/100
Participants with impaired hearing (n = 179) were older (73.9 vs. 71.4 years, p <0.001), often male (61.5% vs. 36.5%, p <0.001), and had lower cognitive scores than normal-hearing individuals (n = 241).
Why it matters
In this cross-sectional study, people with hearing impairment scored lower on cognitive tests than those with normal hearing, and hearing aid use was linked to higher scores on one cognitive measure. Because the study looked at people at a single point in time, it cannot show whether hearing aids prevent or slow cognitive decline.
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Dream recall status was associated with blood p ‐tau217 levels, APOE ε4 carriage, and future cognitive decline among older individuals cognitively healthy at baseline.
Why it matters
In cognitively healthy older adults, higher blood p-tau217 and APOE ε4 carriage were each associated with a lower likelihood of remembering dreams, and non-dream-recallers showed faster cognitive decline over 10 years. This is an observational association and does not show that dream recall affects the disease.
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Among 389,314 participants, CKM stages were distributed as follows: stage 0 (10.0%), stage 1 (8.0%), stage 2 (57.6%), stage 3 (17.9%), and stage 4 (6.5%).
Why it matters
Worsening cardiovascular-kidney-metabolic stages were associated with higher hazards of psychiatric disorders and of subsequent transition to dementia, and advanced stages were linked to all-cause, Alzheimer's, and vascular dementia. The authors emphasise regular monitoring and early intervention to manage progression of this syndrome.
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44/100
Various approaches to advance care planning are in use and generally acceptable also for persons with dementia and their care partners.
Why it matters
This qualitative study interviewed general practitioners about when a scripted medical approach versus a flexible psychosocial approach to advance care planning is preferred for people with dementia. It is about care planning approaches, not treating, curing or preventing Alzheimer's disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Tuning Up the Old Brain with New Tricks: Attention Training via Neurofeedback
- Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type
- Predictors of depression and life satisfaction among spousal caregivers in hospice: application of a stress process model
- Motor neuron disease-inclusion dementia presenting as cortical-basal ganglionic degeneration
- Understanding the moral distress of nurses witnessing medically futile care
- Specialty Palliative Care Consultations for Nursing Home Residents With Dementia
- Evaluation of Wearable Technology in Dementia: A Systematic Review and Meta-Analysis
- No association between metformin initiation and incident dementia in older adults newly diagnosed with diabetes
- Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
- Trust, consistency and transparency: in-home respite needs and preferences of people living with dementia and their carers