Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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We sought to ascertain frequency, type, risk factors of falling, and resulting injuries among parkinsonian patients.
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Renal impairment is associated with an increased risk of carotid atherosclerosis and stroke, determinants of cognitive dysfunction and dementia.
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Nursing home residents dying with advanced dementia are not perceived as having a terminal condition, and most do not receive optimal palliative care.
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Demented individuals were less likely than their nondemented counterparts to be taking lipid-lowering drugs.
Why it matters
This community-based study compared use of lipid-lowering drugs in older adults with and without dementia. It found that people with dementia were less likely to be taking these drugs, but this does not show that the drugs treat or prevent dementia.
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Low high-density lipoprotein cholesterol is associated with an increased risk for cardiovascular disease and stroke.
Why it matters
In 561 people aged 85, this population-based study assessed whether total and fractionated cholesterol levels were associated with cognitive impairment. It reports an association only and does not test any treatment, cure or prevention for Alzheimer's disease.
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The objective of this study was to describe the occurrence of HIV dementia and neuropsychological testing abnormalities in a new cohort of HIV-seropositive individuals at high risk for HIV dementia and to compare these results to a cohort before the advent of highly active antiretroviral therapy (HAART).
Why it matters
Comparing two groups of HIV-positive people before and after the arrival of combination therapy, this study found no difference in the occurrence of HIV dementia or neuropsychological test abnormalities. It concerns cognitive impairment in HIV infection, not Alzheimer's disease, and tests no treatment, cure or prevention for it.
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These findings indicate that in patients with MCI, the patient's lack of awareness of functional deficits identified by informants strongly predicts a future diagnosis of AD.
Why it matters
In patients with mild cognitive impairment, a greater gap between informant-reported and self-reported functional difficulties predicted progression to Alzheimer's disease within two years with high sensitivity and specificity. This suggests that asking a family member about a patient's daily functioning could help identify who is most likely to develop the disease.
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Mount Carmel Health has developed an APCS and APCU integrated into the mainstream of each of its hospitals, providing an opportunity for a more appropriate focus on end-of-life issues for patients with poor prognoses, intense medical needs, and complex family issues.
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Intractable epilepsy is related to various transient and chronic brain electric and neurochemical disturbances.
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People with dementia or delirium have increased mortality in the 6 months after hip fracture, but depression might take longer to have an effect.
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It has been shown that atrophy of medial temporal lobe structures such as the hippocampus and entorhinal cortex shown on MRI may distinguish patients with Alzheimer's disease from healthy controls.
Why it matters
This study compared visual rating with volumetric measurement of medial temporal lobe atrophy on MRI in 143 patients to see how well each distinguishes Alzheimer's disease from healthy controls. It is about diagnostic imaging methods, not about treating, curing or preventing the disease.
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50/100
This study examines the impact of progressive degeneration of conceptual knowledge on the content words used in connected speech elicited using the Cookie Theft picture description (Goodglass & Kaplan. 1983).
Why it matters
In three patients with semantic dementia followed over time, word production declined in ways predicted by a model based on loss of conceptual knowledge. This describes language decline in a related dementia syndrome and does not test any treatment or cure.
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The Consensus criteria for DLB performed as well in this prospective study as those for AD and VaD, with a diagnostic sensitivity substantially higher than that reported by previous retrospective studies.
Why it matters
This study found that clinical diagnosis of probable dementia with Lewy bodies using consensus criteria had a sensitivity of 0.83 and specificity of 0.95 in this sample. It also found that some cases were missed, and in those false-negative cases significant fluctuation was often present but visual hallucinations and spontaneous motor features of parkinsonism were generally absent.
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The neuroprotective glial cell modulator propentofylline has been used in clinical trials involving more than 800 patients with vascular dementia (VaD).
Why it matters
This report describes clinical trials of propentofylline in vascular dementia, a different condition from Alzheimer's disease, and states that beneficial effects were seen in some domains. It does not provide evidence about treating, curing or preventing Alzheimer's disease.
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The validity of MEC is confirmed in the elderly population, with the same cut-off points recommended in the original standardization.
Why it matters
This study revalidated the first Spanish version of the Mini-Mental Status Examination in a general geriatric population, finding a sensitivity of 89.8% and specificity of 75.1% at a cut-off point of 23/24. Population-based norms confirmed the influence of age and education level on test performance.
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In this consecutive autopsy study, the pathological evidence of HIV encephalitis, which included the presence of giant cells and/or HIV p24 immunopositivity, was found more frequently in drug users (25 of 45; 56%) than in homosexual men (6 of 35; 17%) with AIDS (P < 0.01).
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50/100
Absence of functional surrogate decision-makers is a major barrier to research and clinical decision-making for hospitalized patients with advanced dementia.
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Our data suggest that a single explanation for poststroke dementia is not adequate; rather, multiple factors including stroke features (dysphasia, major dominant stroke syndrome), host characteristics (educational level), and prior cerebrovascular disease each independently contribute to the risk.
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Warfarin anticoagulation with atrial fibrillation, even among "ideal" candidates, appears dramatically underutilized.
Why it matters
This chart review found that many elderly patients with atrial fibrillation were not prescribed warfarin, and that dementia was one reason listed as a relative contraindication to anticoagulation. It is about stroke prevention practice, not about treating, curing, or preventing Alzheimer's disease.
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We evaluated the Lund-Manchester research criteria (LMRC) for frontotemporal dementia (FTD).
Why it matters
In 30 patients with frontotemporal dementia and 30 with Alzheimer's disease, items such as loss of personal awareness, hyperorality, stereotyped and perseverative behavior, progressive reduction of speech, and preserved spatial orientation differentiated the groups. This concerns clinical differentiation, not treating, curing, or preventing Alzheimer's disease.
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The Mini-Mental State Examination (MMSE) measures global cognitive performance and is often used as a screening test for dementia.
Why it matters
This five-year study followed Mini-Mental State Examination scores in 2,537 non-demented older French residents and found scores changed over time with age. It describes normal test score patterns and does not address treating, curing or preventing Alzheimer's disease.
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The dementia caregiving literature is reviewed with the goals of (a) assessing the prevalence and magnitude of psychiatric and physical morbidity effects among caregivers, (b) identifying individual and contextual correlates of reported health effects and their underlying causes, and (c) examining the policy relevance of observed findings.
Why it matters
This review found that caregivers of people with dementia have high rates of depression and anxiety, while evidence for physical health effects was weaker and less consistent. It does not test any treatment, cure, or prevention for Alzheimer's disease itself.
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The association between educational attainment and decline in cognitive function over an interval of 1 year was examined for 14,883 subjects 18 years and older in the National Institute of Mental Health Epidemiologic Catchment Area Study.
Why it matters
This study examined the link between educational attainment and one-year decline in cognitive function in 14,883 people aged 18 and older. It is about education and cognitive change in the general population and does not test any treatment, cure, or prevention for Alzheimer's disease.
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We sought to determine whether neuropsychological impairment in schizophrenia is related to current age, age at onset, or duration of illness, and whether the pattern of such impairment can be distinguished from that caused by progressive dementias of Alzheimer's type.
Why it matters
This study compared neuropsychological test performance in schizophrenia groups, a normal control group and a group with Alzheimer's disease. It concerns schizophrenia and does not show any treatment, cure or prevention for Alzheimer's disease.
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A case-control study among 184 matched pairs of patients 65 years of age and older was undertaken to identify risk factors associated with falls and injuries in a long-term care facility in Baltimore, Maryland, in 1984-1985.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Management and Care for People Living With Dementia and Their Caregivers: Findings From an Italian National Survey on Caregivers and Services Use
- Decision making in frontotemporal dementia: neuropsychological and neuroimaging assessments
- Global epidemiology of dementia: Alzheimer's and vascular types
- Validation of the advance care planning engagement survey in Singapore
- White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study
- Differences in do-not-resuscitate orders, hospice care utilization, and late referral to hospice care between cancer and non-cancer decedents in a tertiary Hospital in Taiwan between 2010 and 2015: a hospital-based observational study
- Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging
- Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities
- Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits
- Dose- and pattern- physical activity is associated with lower risk of dementia