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Parkinsonism and frontotemporal dementia: the clinical overlap
Espay AJ, Litvan I.. Journal of molecular neuroscience : MN, 2011-09-03
Topic: Risk, prevention and care in population studies
Frontotemporal dementia is commonly associated with parkinsonism in several sporadic (i.e., progressive supranuclear palsy, corticobasal degeneration) and familial neurodegenerative disorders (i.e., frontotemporal dementia associated with parkinsonism and MAPT or progranulin mutations in chromosome 17). The clinical diagnosis of these disorders may be challenging in view of overlapping clinical features, particularly in speech, language, and behavior. The motor and cognitive phenotypes can be viewed within a spectrum of clinical, pathologic, and genetic disorders with no discrete clinicopathologic correlations but rather lying within a dementia-parkinsonism continuum. Neuroimaging and cerebrospinal fluid analysis can be helpful, but the poor specificity of clinical and imaging features has enormously challenged the development of biological markers that could differentiate these disorders premortem. This gap is critical to bridge in order to allow testing of novel biological therapies that may slow the progression of these proteinopathies.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Espay, A. J., & Litvan, I. (2011). Parkinsonism and frontotemporal dementia: the clinical overlap. Journal of molecular neuroscience : MN. https://doi.org/10.1007/s12031-011-9632-1
Vancouver
Espay AJ, Litvan I. Parkinsonism and frontotemporal dementia: the clinical overlap. Journal of molecular neuroscience : MN. 2011. doi:10.1007/s12031-011-9632-1. PMID: 21892619.
BibTeX
@article{espay2011-21892619,
author = {Espay, A. J. and Litvan, I.},
title = {{Parkinsonism and frontotemporal dementia: the clinical overlap}},
journal = {Journal of molecular neuroscience : MN},
year = {2011},
doi = {10.1007/s12031-011-9632-1},
pmid = {21892619},
url = {https://doi.org/10.1007/s12031-011-9632-1}
}
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Key findings
- Frontotemporal dementia is commonly associated with parkinsonism in several sporadic (i.e., progressive supranuclear palsy, corticobasal degeneration) and familial neurodegenerative disorders (i.e., frontotemporal dementia associated with parkinsonism and MAPT or progranulin mutations in chromosome 17).
Why it matters
This paper describes the overlapping clinical features of frontotemporal dementia and parkinsonism and notes the difficulty of distinguishing these disorders before death. It reports no treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of molecular neuroscience : MN) |
| Journal's citation record | 1 / 4 | Journal of Molecular Neuroscience: journal h-index 118 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 62 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.6 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 3 / 6 | Cited 3.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Irene Litvan: h-index 110 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Cincinnati: institution h-index 918 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21892619) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
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