Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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A positive family history was reported in 42% of patients in the Alzheimer disease cohort, 48% of patients in the frontotemporal dementia cohort, and 34% in those with other dementia types.
Why it matters
Among patients with dementia, a positive family history was common, and of 38 patients with complete genetic data, 38% carried diagnostically significant variants including APP, PSEN1, MAPT, PGRN, C9ORF72 and APOE4/4. The authors say improved genetic testing infrastructure is needed in memory clinics, and that overly strict onset criteria may miss findings important with the emergence of new anti-amyloid therapies.
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In 2021, dementia accounted for 56.9 million global cases, 2.0 million deaths, and 36.3 million DALYs.
Why it matters
This analysis shows dementia affected 56.9 million people globally in 2021, with high fasting plasma glucose, high body-mass index, and smoking as the main attributable risk factors. It does not test any treatment or cure, but identifies modifiable risk factors that could inform prevention efforts.
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A total of 1,223 articles were identified.
Why it matters
This bibliometric analysis of gait analysis in mild cognitive impairment found growing research interest and emerging frontiers like dual-task walking and digital biomarkers. It highlights challenges such as methodological heterogeneity and small sample sizes, but no treatment or cure is tested.
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< 0.001) for both measures. When distinguishing NC from MCI/DM, the CIST outperformed the K-MMSE, demonstrating a higher AUC (0.869 vs. 0.842) and F1-score (0.697 vs. 0.409).
Why it matters
In older adults without formal education in South Korea, the Cognitive Impairment Screening Test outperformed the K-MMSE in distinguishing normal cognition from MCI or dementia, with a higher AUC and F1-score. The authors say further large-scale validation is warranted, so this is about improving screening, not treating, curing, or preventing Alzheimer's disease.
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The CCAB showed acceptable to good concurrent validity (rs = 0.44-0.79) and reliability (rs = 0.57-0.84).
Why it matters
This study shows that a computerized cognitive battery has acceptable psychometric properties and can measure cognitive performance longitudinally in older adults. It may help provide access to early cognitive assessments, but it does not test a treatment or cure.
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This article synthesizes findings, from the Autism/Dementia Work Group of the 2nd International Summit on Intellectual Disabilities and Dementia, on the nature of autism/autism spectrum disorder and later-age neuropathologies, particularly dementia.
Why it matters
This expert report found limited research on aging and dementia in autistic adults, with dementia prevalence appearing to be influenced by co-occurring intellectual disabilities, particularly Down syndrome. It offers no tested treatment, cure, or prevention for Alzheimer's disease.
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Higher general burden was associated with female caregivers (β = −.19, p = .05), higher education (β = .16, p = .03), caring for someone with dementia (β = .36, p = .01), and greater dysphagia-related burden (β = .33, p = .01).
Why it matters
In this study, greater swallowing difficulty was linked to more burden on care partners of people with neurodegenerative disease including dementia. It recommends asking about and supporting this burden early, but reports no treatment or cure for Alzheimer's disease.
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The final analysis included 636 older dementia patients, with a mean age of 78.2 ± 6.3 years, of whom 187 (29.4%) developed delirium during hospitalization.
Why it matters
Among 636 older dementia patients, a machine learning model predicted delirium during hospitalization with an area under the curve of 0.930, and identified risk factors such as cerebrovascular disease, sedative drug use, and hemoglobin levels. This concerns delirium risk in people who already have dementia and does not treat, cure, or prevent Alzheimer's disease.
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Environmental and lifestyle factors significantly contribute to gynecological cancers.
Why it matters
This review is about environmental and lifestyle factors in gynecological cancers, not Alzheimer's disease, so it provides no information on Alzheimer's treatment, cure or prevention. It describes risk factors such as obesity, diet and pollution for cancers of the ovary, uterus, cervix, vulva and vagina.
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BackgroundPopulation ageing in Africa will increase the burden of Alzheimer's disease and related dementias within the next few decades.
Why it matters
This survey in Nigeria found that only 10% of participants had good knowledge of dementia, with misleading themes in local language translations and none able to name a dementia risk gene. It highlights the need for improved dementia education and genetic research in African populations.
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43/100
A total of 88 participants were included in the study.
Why it matters
This cross-sectional study found an extremely high prevalence of hearing loss (94.2%) in patients with dementia and a statistically significant association between severe hearing loss and dementia severity. It suggests that hearing loss is common in this population and may contribute to dementia severity.
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This study aims to analyze temporal trends in the prevalence and disability-adjusted life year (DALY) burden of early-onset dementia (EOD) globally from 1990 to 2021 and assess the attributable burdens of modifiable risk factors.
Why it matters
This global analysis found that the number of early-onset dementia cases and DALYs nearly doubled from 1990 to 2021, with high fasting plasma glucose as the most significant attributable risk factor for related DALYs globally. It also noted that the PAF for high body mass index and high fasting plasma glucose increased in nearly all regions since 1990, while the PAF for smoking decreased.
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43/100
Managing complex disaster risks requires interdisciplinary efforts.
Why it matters
This paper is about disaster risk reduction, AI, big data, and law, and contains no information on Alzheimer's disease treatment, cure, or prevention.
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To date, the impact of cognitive therapies on patients with dementia and mild cognitive impairment (MCI) has been studied in terms of cognition, quality of life and activities of daily living rather than in the context of neuropsychiatric symptoms (NPS).
Why it matters
This scoping review found that art therapy and reminiscence therapy improved neuropsychiatric symptoms in the most articles, while cognitive training was least effective. It addresses symptom management in people with mild cognitive impairment or dementia, not curing or preventing Alzheimer's disease.
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Four main themes and 10 subthemes were identified.
Why it matters
In interviews with people with dementia, their families, and healthcare professionals, pain was often not recognized because of communication barriers and a lack of training in carers. The authors call for formal training and easy-to-use pain assessment tools.
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Higher segregation, indicated by lower tract and county-level interaction, was associated with better cognitive and everyday functioning levels but faster rates of decline.
Why it matters
Among Black older adults in the ACTIVE study, higher segregation was linked to better initial cognitive and everyday functioning but faster decline over time. No link was found for one measure of segregation, and the authors note that interventions at multiple levels may help reduce disparities.
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This study aimed to develop a novel classification model using wearable two-channel electroencephalography (EEG) data to differentiate between patients with dementia and normal controls (NCs).
Why it matters
Using two-channel wearable EEG in 54 normal controls and 29 patients with dementia, this study found significant differences in several EEG features and a classification model that achieved a balanced accuracy of 97.05%. The authors suggest this could be a valuable diagnostic tool, but it is a diagnostic study, not a treatment, cure, or prevention.
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Caregivers of patients with BPSD reported significantly greater psychological distress, burden, and poorer sleep quality than those caring for patients without BPSD.
Why it matters
This study found that caregivers of dementia patients with behavioral and psychological symptoms reported more distress, burden and poorer sleep than caregivers of patients without such symptoms. It points to the need for interventions to manage these symptoms in order to ease caregiver distress, but does not address treating or preventing dementia itself.
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Probable dementia caregiving predicted worse sleep quality, which mediated the relationship with higher depressive symptoms.
Why it matters
This study found that probable dementia caregiving predicted worse sleep quality, which mediated higher depressive symptoms, and that the link between interrupted sleep and depression was strongest under low support. No significant effects were observed among rural caregivers, and the study does not test any dementia treatment or cure.
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Four themes were found: sense of self, connection to others, acceptance versus resistance in the face of adversity, and orientation toward the future versus focus on the present.
Why it matters
This qualitative interview study found that quality of life and values like sense of self and connection to others influence advance care planning in people with young-onset dementia and their family caregivers. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Two logic models were developed to identify the determinants of risk for dementia and how these could be targeted by the program.
Why it matters
This paper describes the development of a web-based program for dementia literacy and risk factor reduction, with a pilot study reporting excellent usability and acceptance scores. The program was designed using logic models and co-creation with experts, stakeholders, and citizen advisors to balance scientific content with the needs of older adults.
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Flexible and wearable electronics are attracting surging attention due to their potential applications in human health monitoring and precision therapies.
Why it matters
This paper describes a wearable sensor for detecting hazards such as magnetic fields and for monitoring body movements, and does not address Alzheimer's disease. It provides no information on treating, curing or preventing Alzheimer's disease.
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The overall rate of dementia was higher in PLHIV than that in POHIV (22% vs 10%; p = 1.4e).
Why it matters
In Malawi, dementia was more common in people living with HIV (22%) than in people without HIV (10%), with older age, unemployment and depression as risk factors. This record review provides groundwork for future dementia research in the region but does not test any treatment or prevention approach.
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The statistical analysis revealed that the survival time was significantly longer in females compared to males (p = 0.003).
Why it matters
This cohort study found no significant correlations between PEG placement and age at death, survival time, or palliative performance scores, though it identified a moderate positive correlation between follow-up time and survival after PEG placement. The main reason for PEG requests was dysphagia, especially in patients with dementia and oncological diseases.
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The findings revealed a significant negative correlation between fatigue and hope (r = -.431, p <.01), a significant positive correlation between fatigue and anxiety (r =.584, p <.01), and a significant negative correlation between hope and anxiety (r = -.364, p <.01).
Why it matters
This study found that hope mediated the relationship between anxiety and fatigue in dementia family caregivers, accounting for 15.6% of the mediating effect. It suggests that fostering hope may help alleviate caregiving fatigue and enhance well-being.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Racial and Ethnic Differences in Hospice Use and Hospitalizations at End-of-Life Among Medicare Beneficiaries With Dementia
- New therapies for treating Down syndrome require quality of life measurement
- Patient Self-Defined Goals: Essentials of Person-Centered Care for Serious Illness
- “Diagnose & Adios”: Multi-Perspective Insights on Formal Service Use in Dementia Family Caregivers
- Differences in Dementia Diagnosis Rates in Primary Care in Traditional Medicare and Medicare Advantage
- Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach
- From Anxiety, Depression to Major Neurocognitive Disorders: Exploring Their Association With the Risk Factors for Dementia
- Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study
- An innovative model of behavioral healthcare for older adults with serious mental illness, substance use disorders, and dementia
- Prediction of Postoperative Delirium in Geriatric Hip Fracture Patients: A Clinical Prediction Model Using Machine Learning Algorithms