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Novel MRI techniques in the assessment of dementia
Teipel SJ, Meindl T, Grinberg L, Heinsen H, Hampel H.. European journal of nuclear medicine and molecular imaging, 2008-03-01
Topic: Risk, prevention and care in population studies
Plain-language summary
Introduction Positive markers of Alzheimer's disease (AD) have been established in MRI that may allow early detection of AD in at-risk groups. In the near future, these markers will be of high relevance for the selection of at-risk subjects in secondary preventive trials. Methods We describe the methodology and diagnostic value of manual volumetry of the hippocampus and entorhinal cortex, automated voxel-based morphometry, cortical thickness measurement, basal forebrain volumetry and deformation-based morphometry, implementing multivariate statistics and machine learning algorithms to improve group separation and prediction of AD in at-risk groups. We also describe the methodological basis and results obtained in AD using the recently developed technique of diffusion tensor-based morphometry (DTI). This technique gives access to the integrity of subcortical fibre systems in the human brain. Results The best established structural biomarker of AD to date is hippocampus volume that already has been implemented as secondary endpoint in clinical trials on disease modification in AD. Automated approaches will gain an increasing role as endpoints of clinical trials in the near future given the interest in these techniques expressed by the regulatory authorities. DTI is still a developing field where analysis techniques are presently being devised to make optimal use of the multivariate data. Data on changes of fibre tract in preclinical AD are still limited, but the first results are promising in respect to a further enhancement of diagnostic accuracy by combining MRI and DTI. Conclusion Besides their diagnostic use, MRI and DTI will broaden our understanding of the pathophysiology of AD and the structural and functional basis of normal cognition.
What this study adds
Evidence grade: Low
This is a narrative review. This review describes MRI techniques for detecting Alzheimer's disease early, noting that hippocampus volume is the best established structural marker and is already used as a secondary endpoint in clinical trials. It is about imaging markers for detection and trial design, not about treating, curing or preventing the disease.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Teipel, S. J., Meindl, T., Grinberg, L., Heinsen, H., & Hampel, H. (2008). Novel MRI techniques in the assessment of dementia. European journal of nuclear medicine and molecular imaging. https://doi.org/10.1007/s00259-007-0703-z
Vancouver
Teipel SJ, Meindl T, Grinberg L, Heinsen H, Hampel H. Novel MRI techniques in the assessment of dementia. European journal of nuclear medicine and molecular imaging. 2008. doi:10.1007/s00259-007-0703-z. PMID: 18205002.
BibTeX
@article{teipel2008-18205002,
author = {Teipel, S. J. and Meindl, T. and Grinberg, L. and Heinsen, H. and Hampel, H.},
title = {{Novel MRI techniques in the assessment of dementia}},
journal = {European journal of nuclear medicine and molecular imaging},
year = {2008},
doi = {10.1007/s00259-007-0703-z},
pmid = {18205002},
url = {https://doi.org/10.1007/s00259-007-0703-z}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- We also describe the methodological basis and results obtained in AD using the recently developed technique of diffusion tensor-based morphometry (DTI).
- Results The best established structural biomarker of AD to date is hippocampus volume that already has been implemented as secondary endpoint in clinical trials on disease modification in AD.
- Data on changes of fibre tract in preclinical AD are still limited, but the first results are promising in respect to a further enhancement of diagnostic accuracy by combining MRI and DTI.
Why it matters
This review describes MRI techniques for detecting Alzheimer's disease early, noting that hippocampus volume is the best established structural marker and is already used as a secondary endpoint in clinical trials. It is about imaging markers for detection and trial design, not about treating, curing or preventing the disease.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of nuclear medicine and molecular imaging) |
| Journal's citation record | 2 / 4 | European Journal of Nuclear Medicine and Molecular Imaging: journal h-index 224 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 97 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.8 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 7.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Harald Juergen Hampel: h-index 136 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Ludwig-Maximilians-Universität München: institution h-index 1,224 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18205002) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
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