Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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1. Neuropsychological assessments indicated that the CSVD group scored significantly lower than the HC group in general cognitive level, memory, visuospatial ability, executive function, and language function (p < 0.05). 2.
Why it matters
This study found that patients with cerebral small vessel disease-related cognitive impairment scored lower on cognitive tests and showed different resting-state EEG microstate patterns compared to healthy controls. These EEG measures were correlated with cognitive scores, but the study does not test any treatment, cure, or prevention.
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41/100
Higher intakes of total sugar (HR = 1.292, 95 % CI = 1.148--1.453) and free sugar intake (HR = 1.254, 95 % CI = 1.117--1.408) were significantly associated with increased dementia risk.
Why it matters
This study found that higher intakes of total sugar, free sugars, sucrose, and non-milk extrinsic sugars were associated with increased dementia risk, particularly in women, with no significant associations in men. It suggests that reducing sugar intake may help lower dementia risk, but it does not show that doing so prevents dementia.
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41/100
Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as one of the leading causes of cancer-related deaths worldwide.
Why it matters
This review covers public health strategies for hepatocellular carcinoma, including vaccination, antiviral therapy, and surveillance. It does not address Alzheimer's disease.
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Bivariate analyses showed that chain grocery store shoppers reported significantly greater fruit and vegetable intake (2.42 vs. 2.14 times/day for independent grocery store shoppers, p < 0.001) and lower rates of food insecurity compared to independent store shoppers (45.9% vs. 65.3% for independent grocery store shoppers, p < 0.001).
Why it matters
This study examines grocery store access, transportation and food security in Detroit during COVID-19, not Alzheimer's disease, so it offers nothing on treating, curing or preventing Alzheimer's. It found chain store shopping was associated with higher fruit and vegetable intake.
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The Extra Trees model achieved up to 99% accuracy for personalized wristband data, while the multilayer perceptron model performed best in general models with 98% accuracy.
Why it matters
In this pilot study, a system using wristband and video data detected and predicted agitation episodes in people with dementia, in some cases at least six minutes in advance. It is an observational pilot about monitoring a behavioral symptom, not a treatment, cure or prevention of Alzheimer's disease.
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Six key themes emerged: (1) challenges in daily care; (2) strain from behavioral and sleep disruptions; (3) difficulties in seeking help; (4) personal sacrifices of caregivers; (5) emotional burdens associated with caregiving, including comorbidity concerns of PwD; (6) limited dementia knowledge and essential caregiving skills.
Why it matters
Family caregivers in Vietnam described challenges including daily care difficulties, sleep disruptions, emotional burdens, and limited dementia knowledge and caregiving skills. The study calls for educational and support programs covering dementia knowledge, comorbidity management, help-seeking, self-care, and caregiving skills.
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Compared with stage 0 CKM syndrome, stages 3 and 4 were significantly associated with an increased risk of dementia (hazard ratio [HR], 1.35; 95% confidence interval [CI], 1.14-1.59; HR, 1.80; 95% CI 1.57-2.07).
Why it matters
This study found that higher stages of cardiovascular-kidney-metabolic syndrome were linked to a higher risk of dementia, with systemic inflammation playing a mediating role. It suggests that early and comprehensive management of poor cardiovascular-kidney-metabolic health may help reduce dementia risk.
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Shorter telomeres were linked to stress, poor sleep, inflammation, and cardiometabolic markers.
Why it matters
Among Black family caregivers of people with dementia, greater perceived stress was tied to shorter telomeres and to markers of cardiometabolic risk. The authors state more research is needed to uncover the mechanisms, so no intervention or prevention effect is shown.
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Dementia with Lewy bodies (DLB) is thought to be the second most common form of dementia after Alzheimer’s disease, and is characterised by a combination of cognitive, neuropsychiatric and motor symptoms.
Why it matters
This review discusses current management strategies for dementia with Lewy bodies, noting that cholinesterase inhibitors are frontline for cognitive decline and that no disease-modifying therapies exist. It highlights emerging evidence for other therapies but states further evidence is needed, so no cure or prevention is available.
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Consistent with previous research, transfer gains from the OMT condition to an untrained VM task suggest that olfaction may contribute to a‐modal representations of memory.
Why it matters
In this trial of 53 older adults with subjective cognitive decline, olfactory-based memory training improved performance on the trained olfactory memory task and on an untrained memory task, while visual training improved the visual memory task. The findings suggest training gains may transfer to untrained tasks in the olfactory group, but the sample was small.
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These findings highlight the importance of tailoring interventions to caregiver characteristics and outcome type.
Why it matters
This meta-analysis of 175 studies found that caregiver interventions generally reduced anxiety and depression, with varied effects on subjective well-being. Younger, male, and non-spousal caregivers tended to show greater reductions in anxiety and depression.
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41/100
RoCA classifies patients similarly to gold standard paper-based tests, with a receiver operating characteristic area under the curve of 0.81 (95% CI 0.67-0.91; P<.001).
Why it matters
This open-label study found that a rapid online cognitive assessment classified patients similarly to gold standard paper-based tests. It is a small study and further work is required to evaluate generalizability; it does not test a treatment or cure.
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Dementia is becoming a major public health problem in Sub-Saharan Africa (SSA), with prevalence increasing due to demographic transitions, increasing life expectancy, and increasing prevalence of non-communicable diseases.
Why it matters
This commentary describes dementia epidemiology, risk factors, and management challenges in Sub-Saharan Africa, noting that low educational status is the most powerful modifiable risk factor. It is a descriptive overview and does not test any treatment or prevention intervention.
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Alzheimer’s disease (AD) presents significant challenges in clinical practice due to its heterogeneous manifestation and variable progression rates.
Why it matters
This study developed an anatomical staging framework using brain imaging data that predicted progression from MCI to Alzheimer's disease with better accuracy than traditional risk assessment, identifying four distinct disease subtypes with different progression rates. The work is about predicting progression and capturing disease heterogeneity, not about treating or curing the disease.
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There were 558 respondents from residential aged care, community/primary care and hospital settings across all Australian states and territories.
Why it matters
This survey of health and aged care workers in rural and remote Australia found that most considered dementia care in their workplace inadequate and training insufficient. It addresses care quality and training gaps, not treating, curing, or preventing Alzheimer's disease.
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There are meaningful differences in the readability of patient information generated by different large language models.
Why it matters
This study compared the readability of patient information leaflets on Alzheimer's disease, vascular dementia and delirium generated by three large language models, finding ChatGPT produced the most readable content. It concerns health communication quality and does not test any treatment, cure or prevention.
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41/100
EDDA achieved an area under the receiver-operating characteristic curve (AUROC) of 0.85 in the test set and 0.93 in the validation set.
Why it matters
A machine learning algorithm detected dementia in emergency department patients with good accuracy, though agreement with clinician-adjudicated diagnoses was only moderate. This is a detection tool, not a treatment, cure, or prevention.
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demonstrated high goodness of fit and satisfied all validation metrics.
Why it matters
This study developed and validated a way to convert MMSE scores into CDR-SB scores so results can be compared across datasets. It is a measurement tool and does not treat, cure or prevent Alzheimer's disease.
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Recent advances in dementia research have expanded our understanding of modifiable risk factors, with air pollution being a well-established contributor.
Why it matters
This review proposes chronic microplastic exposure as a possible new risk factor for dementia, describing mechanisms such as oxidative stress, neuroinflammation, and accelerated amyloid-beta pathology, and notes higher microplastic concentrations in the brains of dementia patients than controls. It is a review of emerging evidence and does not show that reducing microplastic exposure prevents or treats Alzheimer's disease.
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Although the ASPR and ASIR remained stable or decreased globally, they both greatly increased in East Asia (ASPR: EAPC = 0.43; 95% CI 0.35, 0.51; ASIR: EAPC = 0.40; 95% CI 0.33, 0.47).
Why it matters
Although global dementia rates were stable or decreased, prevalence and incidence rose greatly in East Asia, and early-onset dementia burden increased among females in parts of Africa and the Middle East. The paper highlights regional inequalities and calls for action but does not test any treatment, cure, or prevention.
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Delirium, a severe neuropsychiatric syndrome characterised by acute deficits in attention and self-awareness, is common among elderly inpatients, with incidence increasing with age and prolonged hospitalisation.
Why it matters
In this small prospective study of emergency department patients, delirium was significantly associated with older age, antipsychotic use, frailty, number of medications, Alzheimer's disease and other dementias, and mortality. It describes risk factors and outcomes of delirium, not a treatment or prevention for Alzheimer's disease.
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Of the 747 studies identified, 6 studies fulfilled the eligibility criterion for this review.
Why it matters
This review of 6 studies found that computer-based cognitive training improved global cognition and executive function in people with mild cognitive impairment in Parkinson's disease, but mood was mostly unaffected. The authors note potential methodological biases that need to be considered.
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Emotion scores for fear and surprise were significantly higher for the AD group than for the MCI group during dual tasks (p=0.016), while emotion scores for joy were significantly higher for the MCI group than for the AD group during creative activities (p=0.012).
Why it matters
This study looked at emotions during rehabilitation activities in people with mild cognitive impairment and Alzheimer's dementia, and it did not test any treatment, cure or prevention. It suggests that activities and support could be tailored to patients' emotions, but it provides no evidence about changing the disease itself.
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is a heuristic that seeks to develop methodologies capable of identifying subtle behavior(s) that may flag emerging AD and other dementia related syndromes.
Why it matters
This paper proposes that digital neuropsychological assessment, by analysing time-based measures, may help detect early cognitive difficulties that are prognostic for mild cognitive impairment and dementia. It is about early detection and does not report any treatment, cure or prevention.
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Twenty-six percent of eligible ED users contacted elected for study enrollment.
Why it matters
This study found that telephone-based cognitive assessments can be carried out in older adults after emergency department discharge, and that one assessment had a significant relationship with healthcare utilization. It is a feasibility study with a non-representative sample and does not test a treatment or cure.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Can we learn lessons from the FDA's approval of aducanumab?
- Racial/Ethnic Disparities in Hospital Readmission and Frequent Hospitalizations Among Medicare Beneficiaries With Alzheimer’s Disease and Related Dementia: Traditional Medicare Versus Medicare Advantage
- Needs of key stakeholders to make advance care plans and advance directives for people with dementia: a scoping review
- Enhancing caregiver health: findings from the resources for enhancing Alzheimer's caregiver health II intervention
- Cognition in Whitehall II 'SuperAgers': An Analysis of Dementia Risk Factors
- Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort
- The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
- How Effective Are Dementia Caregiver Interventions? An Updated Comprehensive Meta-Analysis
- Usability and User Experience of Cognitive Intervention Technologies for Elderly People With MCI or Dementia: A Systematic Review
- Effects of comprehensive intervention on life quality among the elderly with Alzheimer Disease and their caregivers based on mixed models