Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Aging is associated with progressive changes in learning and memory.
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These findings confirm that MCI is associated with widespread cortical atrophy.
Why it matters
In this group of people with early Parkinson's disease, those with mild cognitive impairment showed widespread thinning of the cortex, and some thinning was already present in cognitively normal patients. This concerns Parkinson's disease rather than Alzheimer's disease, and it does not test any treatment.
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The incidence of CA-AKI among all hospital admissions was 4.3% compared with an incidence of 2.1% of HA-AKI, giving an overall AKI incidence of 6.4%.
Why it matters
This study compared kidney injury acquired in the community versus in hospital and found community-acquired cases were more often stage 3 and had better adjusted survival. It contains no information about treating, curing or preventing Alzheimer's disease.
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This German study challenged the common assumption that keeping a person with dementia at home is always cheaper than nursing home care.
Why it matters
This German study found that, looking at total costs to society including the value of unpaid family caregiving, community care was actually more expensive than nursing home care once the researchers accounted for how impaired patients were. The extra cost came almost entirely from the large amount of unpaid informal care that families provide at home.
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Most very old community-dwelling individuals, especially the severely cognitively impaired, died away from home.
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Poverty was associated with smaller white and cortical gray matter and hippocampal and amygdala volumes.
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A range of lifestyle factors and underlying medical conditions are associated with an increased risk of CAP in European adults.
Why it matters
This review is about community-acquired pneumonia in adults in Europe, not about treating, curing or preventing Alzheimer's disease. It reports that dementia is among the comorbid conditions that increase the risk of community-acquired pneumonia by twofold to fourfold.
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To examine the association between dietary habits, cognitive functioning and brain volumes in older individuals, data from 194 cognitively healthy individuals who participated in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort were used.
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52/100
Research in gerontology has demonstrated mixed effects of social support on cognitive decline and dementia: Social support has been shown to be protective in some studies, but not in others.
Why it matters
This longitudinal study investigated whether loneliness explains the link between social support and cognitive functioning in later life. It examines social and psychological factors, not a treatment, cure or prevention of Alzheimer's disease.
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The AS task is a useful measure of executive function across the AD spectrum.
Why it matters
This study found that performance on an eye-movement task was impaired in people with Alzheimer's disease but not in those with mild cognitive impairment, and in mild cognitive impairment it correlated with thinning in certain cortical regions. It is a study of a cognitive test and does not test any treatment, cure, or prevention.
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Underlying cause of death has a marked effect on place of death.
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52/100
TBI is an independent significant risk factor of developing dementia even in the mild type.
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The authors observed that “Our findings showed that nurses provided chronic disease management that was acceptable, feasible and sustainable.”
Why it matters
This article discusses patient and physician adherence in hypertension management, including nurse-led programs that improved blood pressure control. It does not address treating, curing, or preventing Alzheimer's disease.
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The paper highlights elevated levels of burden experienced by patients with palliative care requirements.
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52/100
Adjustment to admission to residential care can be difficult for people with dementia and their family caregivers.
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In this large-scale prospective epidemiological study, we examined associations of long-term adherence to the Mediterranean diet (MeDi) and subsequent cognitive function and decline.
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Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia.
Why it matters
This review reports that people at all stages of chronic kidney disease have a higher risk of developing cognitive disorders and dementia, possibly through cerebrovascular lesions or direct neuronal injury by uremic toxins. It discusses possible mechanisms but does not test any treatment, cure, or prevention for Alzheimer's disease.
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[(11)C]PIB scans were positive in 40 of 66 (61%) patients with a clinical diagnosis of Alzheimer's disease (AD), 5 of 18 (28%) patients with frontotemporal dementia (FTD), 4 of 5 (80%) patients with Lewy body dementia, and 3 of 10 (30%) patients with other dementias. [(18)F]FDG uptake patterns matched the clinical diagnosis in 38 of 66 (58%) of AD patients, and in 6 of 18 (33%) FTD patients.
Why it matters
Adding amyloid and glucose metabolism PET scans to standard assessment changed the clinical diagnosis in 23% of patients in a memory clinic, mostly when prior diagnostic certainty was low. This is about improving diagnosis, not about treating, curing, or preventing Alzheimer's disease.
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Longitudinal neuroimaging (LNI) studies are rapidly becoming more prevalent and growing in size.
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A motor-based MCR syndrome provides a clinical approach to identify individuals at high risk for dementia, especially vascular dementia, to target for further investigations and who may benefit from preventive interventions.
Why it matters
This study found that older adults with cognitive complaints and slow gait, called motoric cognitive risk syndrome, had a higher risk of developing dementia and vascular dementia. It identifies a group at higher risk but does not show that any treatment, cure, or prevention is possible.
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Disability is commonly considered as an irreversible condition of advanced age.
Why it matters
This paper describes a French platform for evaluating frailty and preventing disability in people aged 65 and older screened for frailty. It concerns frailty and disability prevention generally and does not report any Alzheimer's disease treatment, cure or prevention result.
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AMI is the first French longitudinal study on health and aging set up in a population of elderly farmers living in rural area through a multidisciplinary approach.
Why it matters
This describes the design of a cohort study of elderly retired farmers in rural France, focused mainly on dementia, with data collected on many health and lifestyle factors. It reports no results on treating, curing or preventing Alzheimer's disease.
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The Minority Aging Research Study (MARS) is a longitudinal, epidemiologic cohort study of decline in cognitive function and risk of Alzheimer's disease (AD) in older African Americans, with brain donation after death added as an optional component for those willing to consider organ donation.
Why it matters
This paper describes the design of a study of cognitive decline and Alzheimer's disease risk in older African Americans, including efforts to obtain brain donation. It is about study methods and recruitment, not about any treatment, cure or prevention.
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The sources of stress for families of nursing home (NH) residents with advanced dementia have not been well described.
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The CDR-SB assesses both cognitive and functional domains of AD disability.
Why it matters
Many Alzheimer's drug trials need one score that shows whether patients are getting worse more slowly. Using records of 382 people with early or mild Alzheimer's from the ADNI research study, this paper found that the Clinical Dementia Rating Sum of Boxes captures both thinking and everyday functioning, in roughly equal parts, and that average scores declined nearly linearly over two years. The authors conclude that this makes it "attractive as a primary outcome measure". The study tests a measuring tool, not a treatment.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Association between self-reported dental health status and onset of dementia: a 4-year prospective cohort study of older Japanese adults from the Aichi Gerontological Evaluation Study (AGES) Project
- Subsyndromal delirium in older people: a systematic review of frequency, risk factors, course and outcomes
- Performance on an Everyday Life Activity in Persons Diagnosed with Alcohol Dependency Compared to Healthy Controls: Relations between a Computerized Shopping Task and Cognitive and Clinical Variables†
- Dementia, stroke, and vascular risk factors; a review
- Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
- Dietary patterns and cognition in older persons
- Chronic Obstructive Pulmonary Disease and Risk of Dementia and Mortality in Lower to Middle Income Countries
- Dementia in Africa: Current evidence, knowledge gaps, and future directions
- Heart Failure, Dementia is Associated with Increased Stroke Severity, in-Hospital Mortality and Complications
- Artificial intelligence approach to optimise safety for hospitalised patients with dementia