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From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies
Shireen Sindi, Manasa Shanta Yerramalla, Mariagnese Barbera, Charlotta Thunborg, Yunfei Li, Linus Jönsson, Francesca Mangialasche, Chengxuan Qiu et al.. Cerebral Circulation - Cognition and Behavior, 2025-01-01
Topic: Risk, prevention and care in population studies
The demographic transition during the recent decades has resulted in an increase in older adults globally. Cognitive impairment and dementia are the leading causes of functional disability, which significantly decreases the quality of life and increases the use of healthcare resources and societal costs. The goal of this narrative review is to summarize the recent evidence on the epidemiology of cognitive disorders and dementia, their societal burdens, the potential of multidomain lifestyle interventions, the implementation of such interventions and the cost-effectiveness of dementia prevention. Our review demonstrates that although population-based studies have shown a stable or decreasing prevalence of dementia during the recent decades in Europe and North America, an opposite trend has been observed in other regions, including low- and middle-income countries where there is an increasing prevalence. Considering the multifactorial etiology of dementia, to date, multidomain lifestyle interventions simultaneously targeting several risk factors, such as the FINGER trial, have been most effective. Such interventions have important beneficial effects for cognition and other outcomes including physical function, reduced multimorbidity and use of healthcare resources, while proving to be cost-effective. More recent efforts have focused on tailoring and adapting multidomain lifestyle interventions to various global regions, while taking into consideration local infrastructures, cultural norms and specific needs. Such global efforts have been coordinated through the World-Wide FINGERS Network, which aims to harmonize trial methodologies to investigate the effects of FINGER-based interventions in different populations to acquire robust globally relevant evidence. Similarly, there is a need to adapt dementia risk prediction models to various geographic settings. For the wider implementation of multidomain lifestyle interventions, different societal and healthcare levels need to be included, such as the community level, primary care, and specialist (e.g. memory) clinics, and such initiatives are currently being tested in Nordic countries. Taken together, effective multidomain risk reduction programs have the potential to significantly reduce the economic and societal burdens of dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Sindi, S., Yerramalla, M. S., Barbera, M., Thunborg, C., Li, Y., Jönsson, L., et al. (2025). From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies. Cerebral Circulation - Cognition and Behavior. https://doi.org/10.1016/j.cccb.2025.100385
Vancouver
Sindi S, Yerramalla MS, Barbera M, Thunborg C, Li Y, Jönsson L, et al. From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies. Cerebral Circulation - Cognition and Behavior. 2025. doi:10.1016/j.cccb.2025.100385. PMID: 41017958.
BibTeX
@article{sindi2025-41017958,
author = {Sindi, Shireen and Yerramalla, Manasa Shanta and Barbera, Mariagnese and Thunborg, Charlotta and Li, Yunfei and Jönsson, Linus and Mangialasche, Francesca and Qiu, Chengxuan and others},
title = {{From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies}},
journal = {Cerebral Circulation - Cognition and Behavior},
year = {2025},
doi = {10.1016/j.cccb.2025.100385},
pmid = {41017958},
url = {https://doi.org/10.1016/j.cccb.2025.100385}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Cognitive impairment and dementia are the leading causes of functional disability, which significantly decreases the quality of life and increases the use of healthcare resources and societal costs.
- Taken together, effective multidomain risk reduction programs have the potential to significantly reduce the economic and societal burdens of dementia.
Why it matters
This narrative review summarizes evidence that multidomain lifestyle interventions targeting several risk factors, such as the FINGER trial, have been most effective for cognition and other outcomes and appear cost-effective. It supports the potential of such programs to reduce the economic and societal burden of dementia.
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Study details
- Study designnarrative review
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cerebral Circulation - Cognition and Behavior) |
| Journal's citation record | 0 / 4 | Cerebral Circulation - Cognition and Behavior: journal h-index 19 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | Design recorded as “narrative review”, which our rubric does not rank (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 6 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 3 / 6 | Cited 3.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Miia Kivipelto: h-index 107 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Imperial College London: institution h-index 1,744 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41017958) |
| Free to read | 2 / 2 | Free to read |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.cccb.2025.100385
- PubMed: 41017958
- Original source →
- Free full text: Cerebral Circulation - Cognition and Behavior →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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