Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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We found 129 articles that applied transfer learning to MR brain imaging tasks.
Why it matters
This systematic review examined 129 articles that applied transfer learning to brain MRI tasks, most often for dementia-related classification. It is a review of machine learning methods for diagnosis, not a treatment, cure or prevention study.
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Data mining involves the use of mathematical sciences, statistics, artificial intelligence, and machine learning to determine the relationships between variables from a large sample of data.
Why it matters
This review describes how data mining and machine learning have been applied to diagnosis and prediction across several diseases, including mention of Alzheimer's disease. It is a general overview of diagnostic methods and does not test any treatment, cure, or prevention.
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Polysomnography (PSG) represents a fundamental diagnostic tool used in the evaluation of sleep disorders.
Why it matters
This review describes polysomnography as the gold standard for diagnosing sleep-disordered breathing and notes its importance in confirming REM sleep behavior disorder, which is predictive of neurodegenerative disorders. It is a diagnostic review and does not test any treatment, cure or prevention for Alzheimer's disease.
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State case fatality ranged from 3.32% in North Carolina to 9.26% in Connecticut, but for ALs in these states it was 12.89% and 31.59%, respectively.
Why it matters
In assisted living communities across seven states, case fatality ranged from 12.89% in North Carolina to 31.59% in Connecticut, and communities with higher proportions of racial/ethnic minorities had more COVID-19 cases. The study is about COVID-19 in assisted living communities, not about treating, curing, or preventing Alzheimer's disease.
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Dementia decedents were more likely to die at home and other places and less likely to die at institutional settings over the study period.
Why it matters
This analysis found a shift over time toward more dementia decedents dying at home and in communities rather than institutions, with state factors like nursing home bed availability and Medicaid spending linked to place of death. It concerns end-of-life care location, not treating, curing, or preventing Alzheimer's disease.
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Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse nonmotor symptoms (NMS) besides such well-documented motor symptoms as bradykinesia, resting tremor, rigidity, and postural instability.
Why it matters
This review states that people with Parkinson's disease who have cognitive impairment may have a significantly higher risk of progressing to dementia, and that mild cognitive impairment is a harbinger of dementia in Parkinson's disease. It is a review of mechanisms and treatment considerations and does not report results showing that any treatment, cure, or prevention works.
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We believe these algorithms will be of immense value to dementia researchers interested in racial/ethnic disparities.
Why it matters
Older ways of spotting dementia in the US Health and Retirement Study worked unevenly across racial and ethnic groups, which can distort comparisons between groups. This study built new algorithms whose recommended versions differed by no more than 3 points in sensitivity and 5 points in specificity across groups, were 90%–92% accurate overall, and gave group-to-group prevalence ratios within 1%–10% of those from in-person diagnoses. It is a tool for fairer dementia research, not a test for individuals or a finding about treatment or prevention.
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The results of the extended model show that social influence, effort expectancy, facilitating conditions, and behavioral intention (BI) all had P P value for RC and TA was greater than .05, hence were insignificant.
Why it matters
This study of 350 caregivers in sub-Saharan Africa found that social influence, effort expectancy, facilitating conditions, and behavioral intention were significant factors in accepting wearable devices for dementia patients, while resistance to change and technology anxiety were not significant. The study did not report any outcomes related to treating, curing, or preventing Alzheimer's disease.
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Age-related hearing loss (ARHL) or presbycusis, as the third leading cause of chronic disability in older adults, has been shown to be associated with predisposing cognitive impairment and dementia.
Why it matters
This review reports that age-related hearing loss is associated with predisposing cognitive impairment and dementia, and that auditory amplification may improve cognition and quality of life. It recommends regular hearing screening for identification and management, though the mechanisms linking hearing loss to dementia risk remain hypothesized.
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Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia.
Why it matters
This study found that certain aspects of walking (gait) were linked to cognitive decline and dementia in a large group of older adults without dementia at the start. It suggests that measuring how someone walks might help identify people at risk, but it does not show that changing gait prevents or treats dementia.
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Traumatic brain injury (TBI) is an unfortunately common event in military life.
Why it matters
This review discusses traumatic brain injury in military veterans, including blast-related mild TBI, and notes that TBI is a risk factor for neurodegenerative disease. It does not report a treatment, cure or prevention for Alzheimer's disease.
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While people with mild cognitive impairment (MCI) portray noticeably incipient memory difficulty in remembering events and situations along with problems in decision making, planning, and finding their way in familiar environments, detailed neuropsychological assessments also indicate deficits in language performance.
Why it matters
This study used deep neural networks on speech features to identify mild cognitive impairment, with the best models classifying MCI and healthy controls at about 83% accuracy. It is a diagnostic method and does not report any treatment, cure, or prevention for Alzheimer's disease.
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Falls pose a major threat to the well-being and quality of life of older people.
Why it matters
This review discusses fall risk assessment and prevention strategies for older people, including those with dementia and Parkinson's disease. It does not report a treatment, cure or prevention for Alzheimer's disease itself.
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We review the changing conceptions of schizophrenia over the past 50 years as it became understood as a disorder of brain function and structure in which neurocognitive dysfunction was identified at different illness phases.
Why it matters
This review describes how neurocognitive problems are common in schizophrenia and are linked to daily functioning, and notes that cognitive remediation studies have shown promising results while evidence for reversing these problems with medications is limited. It does not report any treatment, cure, or prevention for Alzheimer's disease.
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We studied the validity of longitudinal statistical inferences of clinical trials using minimization, a dynamic randomization algorithm designed to minimize treatment imbalance for prognostic factors.
Why it matters
This is a statistical methods study about a randomization technique called minimization, not a test of any Alzheimer's treatment. It found that when a prognostic factor strongly related to the outcome was not adjusted for, the analysis gave conservative error rates, and that adjusting for it brought error rates close to the intended level.
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Few studies have validated the Spanish-language version of the Montreal Cognitive Assessment (MoCA-S) test in Latin American populations.
Why it matters
This study evaluated the psychometric properties and discriminant validity of the Spanish-language Montreal Cognitive Assessment in 172 older adults in Santiago de Chile, grouped by clinical diagnosis. The provided text does not report the results, so it is unclear how well this version of the test distinguishes between cognitive states.
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Brain injury is associated with acute and chronic hyperglycaemia, insulin resistance, hyperinsulinemia, diabetic ketoacidosis (DKA) and hypoglycaemic events in diabetic patients.
Why it matters
This review describes evidence that diabetes and its metabolic disturbances, including hyperglycaemia and insulin resistance, are associated with brain injury, cognitive deterioration and dementia, and discusses possible mechanisms and prevention strategies. It is a review of evidence and mechanisms, not a trial showing that any treatment prevents dementia.
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Random Forest and LASSO were found to be optimal methods for feature selection.
Why it matters
This study used quantitative EEG measures and machine learning to distinguish Parkinson's disease patients from healthy controls, finding theta power in the temporal left region and the alpha1/theta ratio in the central left region most important. It concerns Parkinson's disease, not Alzheimer's disease, and does not test any treatment, cure or prevention.
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The result indicated that five of the six participants showed additional improvement in measures of quality of life and autobiographical memory.
Why it matters
In this small study of six care home residents with dementia, five showed additional improvement in quality of life and autobiographical memory after digital life storybooks, and staff viewed the tool positively. It is a small preliminary evaluation of a reminiscence activity and does not test treating, curing, or preventing Alzheimer's disease.
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The amnestic mild cognitive impairment/non-amnestic mild cognitive impairment separation is not only theoretical but backed by structural imaging methods and neuropsychological tests.
Why it matters
Structural MRI showed decreased hippocampus, entorhinal cortex and amygdala volumes in amnestic mild cognitive impairment compared with non-amnestic mild cognitive impairment and controls. These structural differences may help distinguish subtypes of mild cognitive impairment, but the study was small and did not test treatment.
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Vascular contributions to cognitive impairment are receiving heightened attention as potentially modifiable factors for dementias of later life.
Why it matters
This review highlights that vascular factors contributing to cognitive impairment are potentially modifiable and have been linked not only to vascular cognitive disorders but also to Alzheimer's disease. It points to prevention of cognitive impairment in later life through modifying cardiovascular and stroke risk, but presents no new trial results.
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The incidence of dementia and obstructive sleep apnea (OSA) increases with age.
Why it matters
This review highlights pathological similarities between obstructive sleep apnea and Alzheimer's disease, noting that rodent and clinical studies suggest sleep apnea impairs brain regions including the medial temporal lobe and promotes hippocampal atrophy linked to memory impairment. It does not show that treating sleep apnea prevents or cures Alzheimer's disease.
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Effective communication by nursing home staff is related to a higher quality of life and a decrease in verbal and physical aggression and depression in nursing home residents.
Why it matters
A brief communication skills training programme for nursing aides in a nursing home reduced caregiver distress in the intervention group. This is about improving communication and caregiver well-being, not about treating, curing or preventing Alzheimer's disease.
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Hearing loss has been linked to many types of cognitive decline in adults, including an association between hearing loss severity and dementia.
Why it matters
Adults with mild-to-moderate hearing loss showed changes in how their brains processed sound, with less activity in temporal cortex and more in frontal areas, and these changes were related to speech perception in noise. The study is about brain changes in hearing loss, which has been linked to dementia, but it does not test any treatment or prevention for Alzheimer's disease.
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There is increasing use of neuroimaging modalities, including PET, for diagnosing dementia.
Why it matters
This review describes how FDG-PET and amyloid PET show different patterns in Alzheimer disease and other dementias and can improve diagnostic accuracy when combined with structural MRI. It is about diagnosis and does not test any treatment, cure, or prevention.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Introduction of a pain scale for palliative care patients with cognitive impairment
- Cognitive impairment in Parkinson's disease and dementia with Lewy bodies
- Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education
- Aesthetic Experience in the Acceptance of Wearable Technology for People With Dementia: Critical Interpretive Synthesis
- Cognitive function in early Parkinson's disease: a population-based study
- Cannabis in Palliative Care: A Systematic Review of Current Evidence
- Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review
- Advance care planning in Japan: Gaps between policy, ethical understanding, and its translation into clinical practice
- Brain Health PRO: Evaluating a Web‐Based Multidomain Intervention to Improve Dementia Literacy and Self‐Efficacy
- Association of hearing impairment with brain volume changes in older adults