Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Older stroke survivors engaging in regular PA had a 38 % reduced risk of dementia [Odds Ratio (OR) =0.62, 95 % Confidence Interval (CI): 0.56-0.69, P < 0.001] and a 44 % lower risk of mortality [Hazard Ratio (HR) =0.56, 95 % CI: 0.52-0.59, P < 0.001].
Why it matters
In older Chinese stroke survivors, regular physical activity was linked to a 38% lower risk of dementia and 44% lower mortality, with benefits moderated by sleep duration. The study suggests physical activity protects against dementia and death in this group, though it is an observational association.
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The REMINDER program contributes to dementia prevention research by combining cognitive, lifestyle, and psychosocial strategies within a group-based format, aiming to foster long-term adherence to brain-protective behaviors.
Why it matters
This is a protocol describing a planned randomized trial of a group program combining cognitive, lifestyle and psychosocial strategies for older adults at risk of dementia. Because it reports no results yet, it cannot show whether the program prevents dementia.
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43/100
At baseline, SCDp were older, had a higher prevalence of hypertension and hypercholesterolemia and had worst performance on tests related to processing speed, verbal fluency, visual memory, verbal memory, and executive functioning.
Why it matters
In people with subjective cognitive decline, lower scores on tests of global cognition, executive functioning and verbal memory predicted progression to mild cognitive impairment or dementia. This suggests that detailed neuropsychological testing, even when scores look normal, may help identify high-risk individuals for early intervention.
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The proposed model demonstrated a sound fit (PCMIN/DF = 2.612).
Why it matters
This study found that caregiving stress strengthens the link between behavioral and psychological symptoms of dementia and caregiver burden, while social support moderates this association. It suggests that interventions should include stress reduction, address patient-specific care needs, and enhance caregiver support systems.
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Frequently reported factors included self-management support, information access, and enhanced communication, although these were not consistently addressed across all reviews.
Why it matters
This umbrella review found that digital interventions for older people with dementia and their caregivers are generally well received, but lack of technical knowledge was the most significant barrier to use. It addresses implementation of digital tools and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Impairments in transactions (47%) and verbal communication (44%) were common at baseline, while impairments in self-care and incontinence ( 40%).
Why it matters
This study found that neuropsychiatric symptoms in behavioral variant frontotemporal dementia are frequent, occur early, and are associated with functional decline, with timely recognition and treatment potentially mitigating impact. It suggests symptom management but no cure or prevention.
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43/100
= 18 556) lived in care homes before death.
Why it matters
This cohort study found that people with dementia who had perfect continuity of GP care had lower total costs in their last year of life than those without continuity. It does not test any treatment, cure or prevention.
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Participants numbered 3334 and had a median age of 62 years.
Why it matters
This survey of 3334 older Australians found midrange knowledge about dementia risk and poor recognition of common misconceptions. It does not test any treatment or prevention method, but suggests messaging could be improved.
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The final models included six predictors: caregivers' social support, caregivers' employment situation, caregivers' average daily care duration, caregivers' monthly family income, caregivers' self-efficacy and PwD's chronic disease.
Why it matters
This observational study built two models that predict psychological distress in informal caregivers of people with dementia using six factors, including social support and self-efficacy. It offers tools for identifying caregivers at risk, but it does not test any treatment, cure, or prevention for Alzheimer's disease.
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Overall, 75.9% of the caregivers reported experiencing at least a mild burden, and the levels of depression, anxiety, and stress among the caregivers were higher than expected.
Why it matters
This cross-sectional study in Kazakhstan found that 75.9% of informal dementia caregivers reported at least mild burden, with higher odds of depression and anxiety among spousal caregivers. The findings concern caregiver mental health support needs and do not address treating, curing, or preventing Alzheimer's disease.
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To balance high-quality measurement of cognitive domains and maintain the ability to perform meaningful cross-national comparisons, each HCAP should include a common set of at least three to four continuously distributed test items per domain that can link domains across studies.
Why it matters
This paper recommends that Harmonized Cognitive Assessment Protocol studies include a common set of at least three to four continuously distributed test items per cognitive domain to enable cross-national comparisons. It advocates for a structured yet adaptable framework that prioritizes measurement precision and cultural relevance.
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Type 2 diabetes (T2D) is increasingly recognized as a risk factor for cognitive impairment, ranging from mild cognitive impairment (MCI) to dementia.
Why it matters
This review describes mechanisms linking type 2 diabetes to cognitive impairment and discusses management strategies including glycemic control, lifestyle changes and certain diabetes drugs that may offer neuroprotective benefits. It concludes that early intervention and personalized strategies are needed, but does not report new trial evidence that these prevent dementia.
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We previously demonstrated that PST/DSJ improved caregiver burden and depressive symptoms among caregivers of adults with Alzheimer’s Disease and related dementias (ADRD), regardless of the number of sessions or boosters received.
Why it matters
In this responder analysis, 55 of 91 caregivers (60.4%) showed a clinically meaningful improvement in caregiver burden and/or depressive symptoms after problem-solving training, with response associated with greater care recipient dementia severity and higher baseline caregiver burden, overload, depressive symptoms, and lower life satisfaction. No personal factors were associated with being a responder, and the study addresses caregiver outcomes rather than treating, curing or preventing Alzheimer's disease.
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The global age-standardised DALY rates of ADRDs per 100 000 population slightly increased from 1331.59 (95% confidence interval (CI) = 881.57, 1781.61) in 1990 to 1347.24 (95% CI = 906.36, 1788.12) in 2021, with an AAPC of 0.04% (95% CI = 0.02, 0.05).
Why it matters
This analysis found that the global burden of Alzheimer's disease and other dementias increased slightly from 1990 to 2021, with care quality also increasing but with significant disparities between countries. It does not test any treatment or cure, but highlights that regions with lower socioeconomic status face rising burdens and declining care quality.
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Lower DTI-ALPS, lower BOLD-CSF coupling, and higher CP volume predicted dementia, but PVS volume did not.
Why it matters
Lower DTI-ALPS, lower BOLD-CSF coupling, and higher choroid plexus volume predicted dementia, while perivascular space volume did not, and DTI-ALPS and choroid plexus volume mediated the effects of white matter hyperintensities and diabetes duration on dementia. This suggests impaired cerebrospinal fluid dynamics may contribute to dementia and partly explain cardiovascular risk links, but it is an observational imaging study and not a treatment.
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The final cohort comprised more than 3 million individuals, with a mean baseline age of 63–65 years and a female proportion of 52–55%.
Why it matters
This study protocol and preliminary results describe a common data model approach across more than 3 million individuals to study hypertension, diabetes, and depression as modifiable risk factors for dementia. The preliminary findings confirm the feasibility of this standardized multi-regional approach for large-scale dementia prevention studies in real-world settings.
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Mild cognitive impairment in Parkinson's disease research has progressed from basic mechanism exploration to a multidisciplinary, integrated clinical-basic stage, following an evolutionary path of "pathological mechanism - clinical phenotype - biomarker - intervention strategy."
Why it matters
This analysis mapped two decades of published research on mild cognitive impairment in Parkinson's disease, a problem that predicts later dementia. Output has grown steadily, led by the United States with China rising fast, and the focus has shifted from basic mechanisms toward brain imaging, biomarkers and diagnostic criteria, with machine learning and neuroinflammation as newer topics. It describes research trends rather than treatment results, and calls for unified diagnostic criteria and better biomarker combinations.
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Four themes were derived from the data analysis as key areas of caregiving needs for Latinos: need to connect socially with others; need for resources to provide care; need to understand dementia and navigating existing resources and future care planning; and need for empathic, culturally congruent healthcare.
Why it matters
This qualitative study identified four areas of unmet need among Latino dementia caregivers: social connection, resources, understanding dementia and planning, and empathic culturally congruent healthcare. The findings are meant to guide future targeted interventions, not to test one.
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The global food system faces unprecedented challenges, including climate-driven agricultural instability, rising malnutrition, and consumer demand for sustainable yet appealing products.
Why it matters
This review is about artificial intelligence in fermentation and personalised diets, and does not address Alzheimer's disease treatment, cure or prevention. It reports findings on food production yields, bioreactor failures and childhood anaemia, along with ethical concerns about data privacy and algorithmic bias.
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Of the 130,605 included patients with ischemic stroke, 12,696 (9.7%) patients developed SHS.
Why it matters
Among people who had a first ischemic stroke, those who also developed stroke-heart syndrome had a 19% higher risk of dementia at one year, mainly vascular dementia, and this raised risk faded and became non-significant after three years. Appropriate antithrombotic therapy and management of other conditions were linked to a 32% lower dementia risk in these patients.
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[95% CI] = 0.148 [0.077-0.219]; executive function, 0.138 [0.067-0.208]; episodic memory, 0.020 [-0.051 to 0.091]; working memory, 0.128 [0.059-0.197]; visuospatial processing, 0.094 [0.023-0.164]) outperformed area-level SES in detecting cognitive deficits, and demonstrated widespread associations with poorer performance across cognitive domains.
Why it matters
This cross-sectional analysis found that individual-level socioeconomic status was linked to cognitive performance in older adults. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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Incorporating RHR into the CAIDE model significantly improved predictive accuracy across Black African, Asian, White, and Native Hawaiian populations (mean AUC range: 0.80-0.91).
Why it matters
This study found that adding resting heart rate to the CAIDE dementia risk model improved predictive accuracy in several populations, but not in the American Indian population. It addresses risk prediction, not treating, curing, or preventing Alzheimer's disease.
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BackgroundElectroencephalogram (EEG) is a promising, non-invasive method for identifying the presence of Alzheimer's disease (AD) by recognizing specific brain activity patterns associated with the disease.
Why it matters
An EEG-based machine learning model could tell apart cognitively unimpaired people from those with moderate-to-severe dementia, and from Alzheimer's patients under 65, but it could not reliably distinguish different dementia types or separate unimpaired people from mild dementia. This is a diagnostic study only and says nothing about treating, curing, or preventing Alzheimer's disease.
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At baseline, MCI participants displayed elevated levels of IL-17A, CX3CL1, CCL11, with a borderline increase of IL-6 and TNFα.
Why it matters
This study found that people with mild cognitive impairment had elevated inflammatory markers at baseline, and that a physical and cognitive training intervention reduced some of these markers while maintaining or increasing anti-inflammatory cytokines and BDNF. It does not show whether this intervention prevents or treats Alzheimer's disease.
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder with multifaceted risk factors, including diet and metabolic dysfunction.
Why it matters
This review used animal models to examine how a cafeteria diet of high-fat, high-sugar, energy-dense foods relates to diabetes and Alzheimer's disease pathology. It found the diet produced insulin resistance and was linked to worse cognitive deficits, more amyloid-beta accumulation and increased neuroinflammation, but these are animal findings.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Mild cognitive impairment due to cerebrovascular disease and Alzheimer’s
- Benzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research
- The impact of human-computer interaction-based comprehensive training on the cognitive functions of cognitive impairment elderly individuals in a nursing home
- Bilingualism does not alter cognitive decline or dementia risk among Spanish-speaking immigrants
- Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content
- Souvenaid in the management of mild cognitive impairment: an expert consensus opinion
- The Aging, Demographics, and Memory Study: study design and methods
- Racial and ethnic differences in disease course Medicare expenditures for beneficiaries with dementia
- Continued Use of Warfarin in Veterans with Atrial Fibrillation After Dementia Diagnosis
- The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening tool for dementia for a predominantly illiterate Chinese population