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50/100

✓ Peer-reviewed alzhub usefulness score 50 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Clinical studies have shown alterations in metabolic profiles when patients with mild cognitive impairment and Alzheimer's disease dementia were compared to cognitively normal subjects. Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998).

Key findings

Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study.
Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998).
In addition, Cox regression was used to analyze the metabolites as predictors of incident hospitalized dementia between baseline and 2011.
There were 141 cases among 1534 participants over a median 17.1-year follow-up period.

Why it matters

This study investigated associations between serum metabolites and cognitive change in middle-aged African American participants. It was based on the idea that metabolic profiles differ in people with mild cognitive impairment and Alzheimer's disease dementia compared with cognitively normal people.

Study details

Participants1,534
Evidence strengthLow

How this study scored 50/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Translational psychiatry)
Journal's citation record	2 / 4	Translational Psychiatry: journal h-index 180 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2017 — within 10 year(s) of the newest study here
Sample size	3 / 4	1,534 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 47 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.3 citations a year over 11 year(s) since 2017
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Eric Boerwinkle: h-index 214 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 28934192)
Free to read	2 / 2	Free to read
Total	50 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Bressler, J., Yu, B., Mosley, T. H., Knopman, D. S., Gottesman, R. F., Alonso, A., et al. (2017). Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study. Translational psychiatry. https://doi.org/10.1038/tp.2017.118

Vancouver

Bressler J, Yu B, Mosley TH, Knopman DS, Gottesman RF, Alonso A, et al. Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study. Translational psychiatry. 2017. doi:10.1038/tp.2017.118. PMID: 28934192.

BibTeX

@article{bressler2017-28934192,
  author  = {Bressler, J. and Yu, B. and Mosley, T. H. and Knopman, D. S. and Gottesman, R. F. and Alonso, A. and Sharrett, A. R. and Wruck, L. M. and others},
  title   = {{Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study}},
  journal = {Translational psychiatry},
  year    = {2017},
  doi     = {10.1038/tp.2017.118},
  pmid    = {28934192},
  url     = {https://doi.org/10.1038/tp.2017.118}
}

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