Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
The total number of new diagnoses of dementia with a vascular component or vascular alone was 202, with 20 cases attributable to pure VD.
Why it matters
Dementias with a vascular component had the second highest incidence after Alzheimer's disease, while pure vascular dementia was rarely diagnosed. The authors note that future prospective studies with extensive neuroimaging would be critical to further understand the epidemiology of vascular dementia.
-
44/100
Half of GUIDE-eligible PwD received care from multiple caregivers and high strain was common even among caregivers considered "low-complexity" under GUIDE.
Why it matters
This study found that half of GUIDE-eligible persons with dementia received care from multiple caregivers, high strain was common even among those considered low-complexity, and use of training, respite care, and support groups was low. It suggests that caregiver identification and assessment standards under GUIDE may overlook many caregivers, but it did not test changes to the model.
-
The combination of antiretroviral therapy (cART) and preventive measures has significantly enhanced the management of Human Immunodeficiency Virus (HIV) infection.
Why it matters
In this cross-sectional study of people living with HIV, the IHDS and MoCA tests appeared useful for detecting cognitive impairment in outpatient settings. The study compared assessment tools and did not test any treatment, cure or prevention for Alzheimer's disease.
-
A total of 114 older adults (mean age 73 ± 10 years, 51% female) and their primary caregivers (mean age 49 ± 16 years, 70% female) participated, of whom 73 were recruited from health facilities and 41 from rural communities.
Why it matters
In 114 older adults with dementia and their caregivers in Benin, better quality of life was linked to lower disability and lower caregiver burden, while higher disability and lower socioeconomic status were linked to greater caregiver strain. It identifies factors affecting well-being and care, not ways to treat, cure, or prevent Alzheimer's disease.
-
3 network types were identified: "Siloed"-small networks, limited task sharing (29.8% of networks); "Small but Mighty"-small networks, high task sharing (23.0% of networks); and "Complex"-large networks, diverse membership, members who share and specialize in task assistance (47.2%).
Why it matters
This study identified three types of caregiving networks for people with dementia, and found that those with small, non-collaborative networks had poorer sleep and their caregivers received less social support. It suggests that helping caregivers build more collaborative networks may reduce isolation and improve outcomes, but it did not test any treatment or cure for dementia itself.
-
In the dementia field, a number of applications are being developed aimed at boosting functional abilities.
Why it matters
In this randomized controlled trial of 43 participants, the HELIX auditory-cognitive training game showed an improvement in the Digit-Triplet-Test within the training group, but this was not significant between training and control groups. No significant improvements were found in any other outcome measures, so it cannot be concluded that the game improves cognition.
-
44/100
The study cohort for the analysis of inpatient palliative care comprised 43,896 patients, while the cohort for the analysis of outpatient palliative care included a total of 37,430 patients.
Why it matters
Using German claims data, this study found that a dementia diagnosis, like a cancer diagnosis, predicted palliative care use, but dementia patients had a lower probability of receiving it than cancer patients. It does not test any treatment, cure or prevention.
-
Among the 45 individuals with dementia, mixed dementia had the highest prevalence (42.4%), followed by AD-only (24.4%), non-AD other dementia (22.2%), and non-AD vascular dementia subtypes (11.1%).
Why it matters
Among 45 people with dementia in the Democratic Republic of Congo, mixed dementia was most common, and cognitive and neuroimaging profiles aligned poorly with biomarker classifications. These preliminary findings suggest plasma biomarkers may help identify dementia subtypes, but no treatment or prevention is tested.
-
• CircS was associated with a 40.1 % increased risk of incident all-cause dementia. • A graded increase in dementia risk with escalating severity of CircS. • The presence of ≥ 3 CircS components was significantly associated with dementia. • There was a synergistic effect of CircS and high genetic risk on dementia.
Why it matters
This longitudinal cohort study found that circadian syndrome was associated with a 40.1% increased risk of incident all-cause dementia, with risk rising as severity increased, and that circadian syndrome and high genetic risk had a synergistic effect. It reports associations and does not test any treatment, cure, or prevention.
-
Formal caregivers exhibited significantly better psychological well-being and self-rated health compared to informal caregivers.
Why it matters
This cross-sectional study found that formal caregivers reported better psychological well-being, self-rated health and more positive caregiving appraisals than informal caregivers, with no statistical difference in coping strategies between the groups. It suggests tailored interventions for caregiver well-being, but does not test any treatment, cure or prevention for dementia.
-
These findings suggest that visual function plays a crucial role in the cognitive and functional abilities of patients with MCI.
Why it matters
This cross-sectional study found that visual function correlated with cognitive performance in mild cognitive impairment, but the association was attenuated after adjusting for activities of daily living. It describes a relationship and does not show that improving visual function treats, cures, or prevents Alzheimer's disease.
-
Higher FBG level at midlife was not associated with an increased risk of dementia.
Why it matters
In this Framingham Heart Study analysis, higher fasting blood glucose at midlife was not linked to increased dementia risk, but among people with diabetes, higher glucose at ages 60 and 70 was linked to later dementia. The authors suggest poorly controlled diabetes at older ages may be a presymptomatic metabolic indicator of dementia, but no treatment is tested.
-
In the last two decades, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has significantly advanced our understanding, technologies, and methods for detecting and diagnosing Alzheimer's disease and related dementias.
Why it matters
This perspective proposes repurposing the Alzheimer's Disease Neuroimaging Initiative toward early detection, new interventions, non-drug treatments, a public health approach, and a diverse international cohort. It is a proposal for future research direction, not a study of a treatment or cure.
-
44/100
Cerebrolysin (CBL) is a combination of neurotrophic peptides and amino acids derived from pig brains.
Why it matters
This review suggests Cerebrolysin could be an effective strategy in preventing and treating vascular dementia by targeting neuroinflammation, blood-brain barrier injury, and chronic cerebral hypoperfusion. However, the underlying neuroprotective effects of Cerebrolysin against vascular dementia neuropathology were not fully elucidated.
-
Among people with dementia, predicted 1-year mortality was higher among those with hip fracture (35.4%) versus those without hip fracture (14.8%), with similar patterns for pneumonia (49.6% vs. 13.0%).
Why it matters
This study found that hip fracture or pneumonia substantially increases mortality and accelerates functional decline in people with dementia compared to those without. It highlights the impact of these events on clinical trajectories but does not report any treatment, cure, or prevention for Alzheimer's disease.
-
Food choices profoundly impact population health and the environment.
Why it matters
This study is about the accuracy of food choice self-reports in a simulated online grocery store, not about Alzheimer's disease, so it provides no information on treating, curing or preventing Alzheimer's. It found that reporting accuracy improved with memory aids, but this concerns shopping surveys only.
-
Out of 796 participants, 793 completed the study.
Why it matters
Among 793 multimorbid primary care patients in Lithuania, cognitive impairment was suspected in 5.1% by MMSE and 4.2% by LT-GPCOG, and was significantly associated with COPD and CKD as well as lower education and unemployment. The authors suggest regular cognitive assessments for multimorbid patients and say the LT-GPCOG was comparable to the MMSE, but this is about screening, not treatment, cure, or prevention.
-
Of the 477 participants (70.9% women, mean age = 63 years), 339 (71.1%) completed the survey immediately after the e-learning, and 241 (50.5%) completed the three-month follow-up survey.
Why it matters
This pre-post study found that a free e-learning program improved knowledge of dementia risk reduction and promoted brain-healthy lifestyle engagement among participants. The study had no control group, so it cannot establish that the program caused the improvements.
-
The incidences of POD and sarcopenia in geriatric hip fracture patients are high.
Why it matters
In this retrospective study of older hip fracture patients, sarcopenia before surgery was strongly linked to postoperative delirium. It identifies a risk factor that might be targeted, but reports no treatment or cure for Alzheimer's disease.
-
Eighteen of 24 participants completed the survey and 15 participated in interviews.
Why it matters
This two-year follow-up of dementia caregivers after a digital health program called WECARE found that caregivers' depressive symptoms and life satisfaction stayed better than at baseline even as caregiving burden increased. It is about supporting caregivers, not about treating, curing, or preventing Alzheimer's disease in patients.
-
Cancer is a leading cause of death in China, and its epidemiological profile has shifted markedly in recent years.
Why it matters
This review is about cancer in China and contains no information on Alzheimer's disease treatment, cure, or prevention. Its findings concern cancer incidence, mortality, survival, and modifiable cancer risk factors such as tobacco, air pollution, alcohol, diet, and unsafe sex.
-
The functions of the heart and brain are closely linked and essential to support human life by the heart-brain axis, which is a complex interconnection between the heart and brain.
Why it matters
This review discusses how heart diseases such as heart failure, myocardial infarction, and atrial fibrillation may affect cognitive function and increase dementia risk through the heart-brain axis. It notes that the underlying mechanism for cardiogenic dementia is not fully elucidated.
-
Exercise trainers played crucial roles that extended beyond the supervision of exercise sessions and contributed to participant engagement in the interventions.
Why it matters
This feasibility study found that remote home-based exercise and cognitive training sessions had high adherence, and that exercise trainers played a key role in delivery. It addresses how to deliver a dementia prevention programme, not whether the programme prevents Alzheimer's disease.
-
Participants with Lewy body dementia described losses associated with communication, continence, and energy leading to a progressive loss of independence.
Why it matters
This longitudinal narrative study found that people with Lewy body dementia and their family caregivers experienced losses and suffering, compounded by a perceived lack of clinical support. It suggests that person-centered, palliative supportive care throughout the disease trajectory could reduce suffering and enhance well-being, but does not test this in a trial.
-
This study examines the difference in functional outcomes among Traditional Medicare (TM) and Medicare Advantage (MA) beneficiaries with Alzheimer’s disease and related dementias (ADRD) during a home health admission, which is unknown.
Why it matters
This study compared functional outcomes during home health admissions between traditional Medicare and Medicare Advantage beneficiaries with dementia. It found Medicare Advantage enrollees were 26% less likely to report improvement or maintenance of daily living scores, which concerns rehabilitation outcomes rather than treating or curing the underlying disease.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson's disease
- Geographic Variation in Prevalence of Adult Obesity in China: Results From the 2013–2014 National Chronic Disease and Risk Factor Surveillance
- Interconnected Challenges in Dementia Caregiving: A Co-occurrence Network Analysis of Burden, Unmet Needs, and System Failures Among Caregivers
- Epidemiology of oral health in older adults aged 65 or over: prevalence, risk factors and prevention
- Palliative care provision in long-term care facilities differs across Europe: Results of a cross-sectional study in six European countries (PACE)
- Factors Influencing Psychological Distress in Caregivers of People with Dementia
- Cognitive stimulation to improve cognitive functioning in people with dementia
- The Hospital Anxiety and Depression Scale
- Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review
- Causal roles of phenotypic age and metabolic health on dementia: a Mendelian randomisation and structure learning study