Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
-
44/100
The heart rate response/recovery (HRR) index, a common indicator for cardiovascular health during exercise, has been linked with neurocognitive disorders and mortality.
Why it matters
This study found that a higher heart rate response/recovery index and recovery ratio were associated with reduced risk of all-cause dementia but not with Alzheimer's disease or vascular dementia, and were correlated with slower cognitive decline in some domains. It suggests that cardiovascular fitness during exercise may be linked to dementia risk, but it does not show that improving fitness prevents dementia.
-
This Viewpoint discusses the Wasteful and Inappropriate Service Reduction (WISeR) model, a new payment model announced by the Centers for Medicare & Medicaid Services Innovation Center to broaden prior authorization in traditional Medicare.
Why it matters
This viewpoint discusses the Wasteful and Inappropriate Service Reduction model, a new payment model to broaden prior authorization in traditional Medicare. It contains no research findings on treating, curing, or preventing Alzheimer's disease.
-
This study aims to explore the utility of artificial intelligence (AI) in classifying dementia severity based on gait analysis data and to examine how machine learning (ML) can address the limitations of conventional statistical approaches.
Why it matters
A support vector machine classifier used gait parameters to categorize dementia severity in a small sample of 34 people with mild cognitive impairment, 25 with mild dementia, 26 with moderate dementia, and 54 healthy controls. The findings highlight the promise of AI-based tools for diagnosis, not for treating, curing, or preventing Alzheimer's disease.
-
Among a matched sample of 15,410,030 beneficiaries, accounting for both provider and patient characteristics, the incident dementia diagnosis rate was 0.11 percentage points lower for MA beneficiaries compared to TM beneficiaries attributed to the same PCP.
Why it matters
This study found that Medicare Advantage beneficiaries were slightly less likely to receive a new dementia diagnosis than similar traditional Medicare beneficiaries seen by the same primary care provider, and were less likely to see dementia specialists. It is about diagnosis patterns, not about treating, curing, or preventing Alzheimer's disease.
-
NHB Hispanic, and NHW participants prevalences were APOE ε4 (32.2%, 27.4%, 17.6%), diabetes (26.1%, 35.0%, 13.9%), hypertension (79.0%, 63.6%, 58.2%), obesity (56.8%, 50.3%, 38.5%), and tobacco dependence (12.9%, 7.5%, 3.9%).
Why it matters
This study found that diabetes, hypertension, APOE ε4, and tobacco dependence each independently predicted lower cognitive performance, and that hypothetically eliminating diabetes and hypertension yielded the largest predicted improvements, especially among non-Hispanic Black and Hispanic participants. The authors suggest population-level interventions targeting diabetes and hypertension could narrow cognitive deficits, but these are modeled projections, not tested treatments.
-
44/100
A total of 260,200 older adults were screened for delirium (median [IQR] age in years: 78.0 [74.0-84.0]; female: 143,402 [55.1%]; non-Hispanic Black: 40,737 [15.8%]; Hispanic: 30,760 [11.9%]; median [IQR] Area Deprivation Index: 4.0 [2.0-6.0]; median [IQR] Charlson Comorbidity Index: 10.0 [8.0-13.0]).
Why it matters
Among 260,200 hospitalized older adults screened for delirium, this study found higher odds of delirium for non-Hispanic Black and Hispanic patients, those in higher Area Deprivation Index neighborhoods, and those with prior dementia. It suggests that social marginalization should be considered an important factor in delirium risk stratification.
-
44/100
During a median follow-up of 13.8 years, 3,035 incident dementia cases were recorded, including 1,304 Alzheimer's disease (AD) cases and 597 vascular dementia (VD) cases.
Why it matters
In this UK Biobank cohort, higher adherence to a healthy sleep pattern was linked to lower dementia risk, and this benefit was partly mediated by preserved grey and white matter integrity. The authors suggest improving overall sleep behaviours may support brain structure and lower dementia risk, but the study is observational.
-
The prevalence of CF was 24.3%. Cerebrovascular disease (OR: 2.39, 95% CI: 1.44-3.97) and peripheral arterial disease (OR: 1.74, 95% CI: 1.03-2.95) were significant risk factors, while higher education (OR 0.85, 95% CI 0.76-0.94) and later diabetes onset (OR: 0.93, 95% CI: 0.88-0.98) were protective.
Why it matters
This cross-sectional study found that cerebrovascular disease and peripheral arterial disease were risk factors for cognitive frailty in older adults with type 2 diabetes, while higher education and later diabetes onset were protective. Because it is cross-sectional, it cannot show cause and effect or that managing these conditions prevents cognitive frailty.
-
44/100
The National Dementia Workforce Study was designed to improve our understanding of the individuals and systems who care for people with dementia, but designing and implementing such a study is challenging due to the large number of patient care organizations, clinical and direct care roles, and locations in which care is provided.
Why it matters
This paper describes the plan for sampling organisations and staff who care for people with dementia in the National Dementia Workforce Study. It is about research methods for studying the dementia care workforce and does not address treating, curing, or preventing the disease.
-
Controlling for demographic/health variables, individuals with aMCI, though not naMCI, showed a higher likelihood of hypertension, diabetes, and hyperlipidemia compared to cognitively normal counterparts, though no differences between aMCI/naMCI.
Why it matters
People with amnestic mild cognitive impairment were more likely to have hypertension, diabetes and hyperlipidemia than cognitively normal counterparts, and Black Americans were more likely to fall into hypertension and diabetes groups regardless of cognitive status. The authors say this underscores the need for tailored interventions to address inequities and reduce the risk of progression to dementia.
-
With this study, we will contribute nationally representative data on health, dementia and cognitive aging in Dominican Republic and Puerto Rico, as well as harmonized data in Cuba to expand understanding of aging and dementia in the Hispanic Caribbean and promote cross-national comparative research around the world.
Why it matters
This paper describes the protocol for a population-based study of older adult health and dementia in Cuba, the Dominican Republic, and Puerto Rico. It aims to contribute data on health, dementia, and cognitive aging, not to test a treatment or cure.
-
44/100
This cross-sectional study examines trends in coverage of glucagon-like peptide-1 receptor agonists, semaglutide and tirzepatide, and prior authorization requirements among Medicare Part D beneficiaries.
Why it matters
This study looked at how often Medicare Part D plans cover semaglutide and tirzepatide and what prior authorization rules they require. It provides no information on treating, curing or preventing Alzheimer's disease.
-
44/100
ApoE4 did not moderate the EF and falls relationship (p ≥ 0.05).
Why it matters
In this cross-sectional study, the ApoE4 gene did not moderate the relationship between executive function and falls, but executive function was associated with fall history in people with unimpaired cognition and MCI, not in those with Alzheimer's dementia. The findings concern fall risk factors rather than treating, curing, or preventing the disease.
-
People with dementia have complex medical, functional, and social needs and experience highly variable care quality and outcomes across the U.S. health care system.
Why it matters
This report describes the methods for a national survey of community clinicians who care for people with dementia, covering their training, practice, and job factors. It is a study plan rather than a treatment trial, so it does not show any effect on treating, curing, or preventing Alzheimer's disease.
-
Across all participants, momentary effects of environmental distractions were minimal.
Why it matters
This study found that environmental distractions had minimal effects on unsupervised digital cognitive assessments in older adults, with some effects depending on cognitive status. It is about the reliability of remote cognitive testing, not about treating, curing, or preventing Alzheimer's disease.
-
The association between type 2 diabetes mellitus (T2DM) and cognitive impairment represents a critical public health concern, particularly against the backdrop of the rising global prevalence of diabetes and aging populations.
Why it matters
This review reports that type 2 diabetes is linked to cognitive decline that may progress to dementia, through mechanisms including insulin resistance, inflammation, vascular injury and oxidative stress. It notes that strict blood sugar control plus lifestyle changes may delay cognitive decline, but says longer-term evidence is still needed.
-
Approximately, 25.7% of rural and 20.8% of urban caregivers reported ≥14 PMHD while 25% of rural and 10% of urban caregivers reported ≥14 PPHD.
Why it matters
This study found that rural caregivers of persons with dementia were less likely to experience short-term mental health problems than urban caregivers, but were significantly more likely to endure more physical health problems after adjustment. The findings concern caregiver health rather than treating, curing, or preventing Alzheimer's disease.
-
44/100
We found moderate or good agreement between self- and RC-administered performance, with intraclass correlation ranging from 0.59 to 0.83.
Why it matters
This preliminary validation study found moderate or good agreement between self-administered and remotely clinician-administered digital cognitive assessments, with no significant difference in performance. The results demonstrate the feasibility of remote self-administration using this platform.
-
LUS and cognitive impairment are strong predictors of delirium in elderly COVID-19 patients.
Why it matters
This prospective study of elderly COVID-19 patients found that a lung ultrasound score above 3 and lower MMSE scores independently predicted delirium during hospitalisation. The authors suggest the lung ultrasound score provides an objective bedside measure of lung pathology severity linked to elevated delirium risk, and call for further validation.
-
A significant correlation was found between perceived cognitive decline and increased motivation to engage in dementia risk reduction behaviors (r = 0.44).
Why it matters
This cross-sectional study found that people who perceived their thinking was declining were more motivated to take up dementia risk reduction behaviors, but this motivation was weaker or absent when dementia-related fear was high. It suggests that public health messages should give people practical, actionable steps rather than emphasizing frightening aspects of dementia.
-
Patients with DLB had significantly greater rates of hospitalization and ED visits compared to patients with AD (Incidence Rate Ratio (IRR): 1.46, 95% CI 1.24, 1.73, IRR: 1.46, 95% CI 1.29, 1.77, respectively) and controls (IRR: 1.77, 95% CI 1.46, 2.14, IRR: 2.21, 95% CI 1.82, 2.69, respectively) and ED visits compared to those with VD (IRR: 1.24, 95% CI 1.03, 1.50).
Why it matters
This study found that patients with early-stage dementia with Lewy bodies had higher rates of hospitalization and emergency department visits than patients with Alzheimer's disease, vascular dementia or controls, and were more likely to have falls-related hospitalizations. It suggests fall prevention and psychiatric treatment may help reduce hospitalizations but does not test any treatment, cure or prevention for Alzheimer's disease.
-
A total of 58 studies met the inclusion criteria, with most conducted in the USA (37.9%) and Europe.
Why it matters
This review found no standardised way to detect delirium in nursing homes and long-term care, and only some of the 25 tools identified had been tested for validity and reliability there. It recommends integrating screening into routine care and training staff, not a treatment for Alzheimer's disease.
-
The aim of this literature review is to examine and contrast four dietary patterns to evaluate their influence on Alzheimer's prevention.
Why it matters
This literature review reports that the Mediterranean, ketogenic, DASH, and MIND diets can all offer benefits in Alzheimer's prevention, with the MIND diet described as promising because it combines features of the Mediterranean and DASH diets. The authors state that choosing the most effective diet requires considering other approaches too, such as physical activity to improve cognitive decline.
-
A preliminary search yielded 4772 studies, of which 12 (0.25%) met the criteria.
Why it matters
This meta-synthesis of 12 qualitative studies found that family caregivers' use of supportive mobile apps is influenced by their perceived value of the apps and their caregiving burden, and that such apps can support caregiving abilities, emotions, social connections, and self-care. It identifies design barriers such as lack of technological literacy, time constraints, and privacy concerns.
-
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac condition, often caused by mutations in genes encoding desmosomal proteins.
Why it matters
This review is about arrhythmogenic cardiomyopathy, an inherited heart condition, and does not address treating, curing or preventing Alzheimer's disease. It discusses exercise risks and prescription for people with this heart condition.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Mild cognitive impairment and dementia: the importance of modifiable risk factors
- Age of dementia diagnosis in community dwelling bilingual and monolingual Hispanic Americans
- An update on semantic dementia: genetics, imaging, and pathology
- Effect of the replacement of dietary vegetable oils with a low dose of extravirgin olive oil in the Mediterranean Diet on cognitive functions in the elderly
- Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates
- Longitudinal driving performance in early-stage dementia of the Alzheimer type
- What is the evidence for cognitive training in preventing cognitive decline in Alzheimer's disease?
- Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial
- Hospice Use Among Medicare Beneficiaries With Parkinson Disease and Dementia With Lewy Bodies
- Mediterranean Diet on Sleep: A Health Alliance